Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats
	Li, Yonghui1,2 ; Li, Sa 1; Sui, Nan2 ; Kirouac, Gilbert J.1; G. J. Kirouac
摘要	Orexins (hypocretins) are novel peptides that have been shown to play a role in control of behavioral arousal. The paraventricular nucleus of the midline thalamus (PVT) is one area of the brain that is the most densely innervated by orexin fibers. In addition, the PVT sends a dense projection to the nucleus accumbens an area, of the striatum involved in the regulation of locomotion. This study was done to determine the effect of microinjections of orexin-A (OXA) or the orexin receptor antagonist SB334867 in the PVT oil locomotor activity (LA) in morphine-naive and morphine-sensitized rats. Microinjections of OXA (3 mu g/500 nl) in or near the PVT inhibited LA in rats tested in a novel and familiar environment as well as in rats expressing behavioral sensitization to repeated injections of morphine. In contrast, microinjections of SB334867 had no effect on LA in any of the test situations. Using an approach involving experimenter based analysis of ethological behaviors; we found that microinjections of OXA in the midline thalamus decreased LA while at the same time increasing the expression of grooming and freezing. These results suggest that OXA can act on the PVT and the midline thalamus to produce arousal independent of LA.; Orexins (hypocretins) are novel peptides that have been shown to play a role in control of behavioral arousal. The paraventricular nucleus of the midline thalamus (PVT) is one area of the brain that is the most densely innervated by orexin fibers. In addition, the PVT sends a dense projection to the nucleus accumbens an area, of the striatum involved in the regulation of locomotion. This study was done to determine the effect of microinjections of orexin-A (OXA) or the orexin receptor antagonist SB334867 in the PVT oil locomotor activity (LA) in morphine-naive and morphine-sensitized rats. Microinjections of OXA (3 mu g/500 nl) in or near the PVT inhibited LA in rats tested in a novel and familiar environment as well as in rats expressing behavioral sensitization to repeated injections of morphine. In contrast, microinjections of SB334867 had no effect on LA in any of the test situations. Using an approach involving experimenter based analysis of ethological behaviors; we found that microinjections of OXA in the midline thalamus decreased LA while at the same time increasing the expression of grooming and freezing. These results suggest that OXA can act on the PVT and the midline thalamus to produce arousal independent of LA. (C) 2009 Elsevier Inc. All rights reserved.
关键词	Orexin Hypocretin Midline thalamic nuclei Paraventricular nucleus of thalamus Locomotion Morphine Arousal Drug addiction Sensitization
学科领域	医学心理学
	2009-10-01
语种	英语
发表期刊	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN	0091-3057
卷号	93 期号:4 页码:506-514
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000269586800021
引用统计	被引频次：40[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5607
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	G. J. Kirouac
作者单位	1.Univ Manitoba, Fac Dent, Dept Oral Biol, Winnipeg, MB R3E 0W2, Canada 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Li, Yonghui,Li, Sa,Sui, Nan,et al. Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,93(4):506-514.
APA	Li, Yonghui,Li, Sa,Sui, Nan,Kirouac, Gilbert J.,&G. J. Kirouac.(2009).Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,93(4),506-514.
MLA	Li, Yonghui,et al."Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 93.4(2009):506-514.

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