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Probing the transformation of discontinuous associations into episodic memory: An event-related fMRI study
Qin, Shaozheng; Piekema, Carinne; Petersson, Karl Magnus; Han, Buxin; Luo, Jing; Fernandez, Guillen; J. Luo; G. Fernandez
2007-10-15
Source PublicationNEUROIMAGE
ISSN1053-8119
SubtypeArticle
Volume38Issue:1Pages:212-222
AbstractUsing event-related functional magnetic resonance imaging, we identified brain regions involved in storing associations of events discontinuous in time into long-term memory. Participants were scanned while memorizing item-triplets including simultaneous and discontinuous associations. Subsequent memory tests showed that participants remembered both types of associations equally well. First, by constructing the contrast between the subsequent memory effects for discontinuous associations and simultaneous associations, we identified the left posterior parahippocampal region, dorsolateral prefrontal cortex, the basal ganglia, posterior midline structures, and the middle temporal gyrus as being specifically involved in transforming discontinuous associations into episodic memory. Second, we replicated that the prefrontal cortex and the medial temporal lobe (MTL) especially the hippocampus are involved in associative memory formation in general. Our findings provide evidence for distinct neural operation(s) that supports the binding and storing discontinuous associations in memory. We suggest that top-down signals from the prefrontal cortex and MTL may trigger reactivation of internal representation in posterior midline structures of the first event, thus allowing it to be associated with the second event. The dorsolateral prefrontal cortex together with basal ganglia may support this encoding operation by executive and binding processes within working memory, and the posterior parahippocampal region may play a role in binding and memory formation.; Using event-related functional magnetic resonance imaging, we identified brain regions involved in storing associations of events discontinuous in time into long-term memory. Participants were scanned while memorizing item-triplets including simultaneous and discontinuous associations. Subsequent memory tests showed that participants remembered both types of associations equally well. First, by constructing the contrast between the subsequent memory effects for discontinuous associations and simultaneous associations, we identified the left posterior parahippocampal region, dorsolateral prefrontal cortex, the basal ganglia, posterior midline structures, and the middle temporal gyrus as being specifically involved in transforming discontinuous associations into episodic memory. Second, we replicated that the prefrontal cortex and the medial temporal lobe (MTL) especially the hippocampus are involved in associative memory formation in general. Our findings provide evidence for distinct neural operation(s) that supports the binding and storing discontinuous associations in memory. We suggest that top-down signals from the prefrontal cortex and MTL may trigger reactivation of internal representation in posterior midline structures of the first event, thus allowing it to be associated with the second event. The dorsolateral prefrontal cortex together with basal ganglia may support this encoding operation by executive and binding processes within working memory, and the posterior parahippocampal region may play a role in binding and memory formation. (c) 2007 Elsevier Inc. All rights reserved.
Keywordepisodic memory hippocampus medial temporal lobe prefrontal cortex discontinuous association simultaneous association
Subject Area认知神经科学
Indexed BySCI
Language英语
WOS IDWOS:000249992900021
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5633
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorJ. Luo; G. Fernandez
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Radboud Univ Nijmegen, FC Donders Ctr Cognit Neuroimaging, NL-6500 HB Nijmegen, Netherlands
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Univ Utrecht, Helmholtz Inst, NL-3584 CS Utrecht, Netherlands
5.Univ Med Ctr Nijmegen, Dept Neurol, NL-6500 HB Nijmegen, Netherlands
Recommended Citation
GB/T 7714
Qin, Shaozheng,Piekema, Carinne,Petersson, Karl Magnus,et al. Probing the transformation of discontinuous associations into episodic memory: An event-related fMRI study[J]. NEUROIMAGE,2007,38(1):212-222.
APA Qin, Shaozheng.,Piekema, Carinne.,Petersson, Karl Magnus.,Han, Buxin.,Luo, Jing.,...&G. Fernandez.(2007).Probing the transformation of discontinuous associations into episodic memory: An event-related fMRI study.NEUROIMAGE,38(1),212-222.
MLA Qin, Shaozheng,et al."Probing the transformation of discontinuous associations into episodic memory: An event-related fMRI study".NEUROIMAGE 38.1(2007):212-222.
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