Probing the transformation of discontinuous associations into episodic memory: An event-related fMRI study
Qin, Shaozheng; Piekema, Carinne; Petersson, Karl Magnus; Han, Buxin; Luo, Jing; Fernandez, Guillen; J. Luo; G. Fernandez
2007-10-15
发表期刊NEUROIMAGE
ISSN1053-8119
文章类型Article
卷号38期号:1页码:212-222
摘要Using event-related functional magnetic resonance imaging, we identified brain regions involved in storing associations of events discontinuous in time into long-term memory. Participants were scanned while memorizing item-triplets including simultaneous and discontinuous associations. Subsequent memory tests showed that participants remembered both types of associations equally well. First, by constructing the contrast between the subsequent memory effects for discontinuous associations and simultaneous associations, we identified the left posterior parahippocampal region, dorsolateral prefrontal cortex, the basal ganglia, posterior midline structures, and the middle temporal gyrus as being specifically involved in transforming discontinuous associations into episodic memory. Second, we replicated that the prefrontal cortex and the medial temporal lobe (MTL) especially the hippocampus are involved in associative memory formation in general. Our findings provide evidence for distinct neural operation(s) that supports the binding and storing discontinuous associations in memory. We suggest that top-down signals from the prefrontal cortex and MTL may trigger reactivation of internal representation in posterior midline structures of the first event, thus allowing it to be associated with the second event. The dorsolateral prefrontal cortex together with basal ganglia may support this encoding operation by executive and binding processes within working memory, and the posterior parahippocampal region may play a role in binding and memory formation.; Using event-related functional magnetic resonance imaging, we identified brain regions involved in storing associations of events discontinuous in time into long-term memory. Participants were scanned while memorizing item-triplets including simultaneous and discontinuous associations. Subsequent memory tests showed that participants remembered both types of associations equally well. First, by constructing the contrast between the subsequent memory effects for discontinuous associations and simultaneous associations, we identified the left posterior parahippocampal region, dorsolateral prefrontal cortex, the basal ganglia, posterior midline structures, and the middle temporal gyrus as being specifically involved in transforming discontinuous associations into episodic memory. Second, we replicated that the prefrontal cortex and the medial temporal lobe (MTL) especially the hippocampus are involved in associative memory formation in general. Our findings provide evidence for distinct neural operation(s) that supports the binding and storing discontinuous associations in memory. We suggest that top-down signals from the prefrontal cortex and MTL may trigger reactivation of internal representation in posterior midline structures of the first event, thus allowing it to be associated with the second event. The dorsolateral prefrontal cortex together with basal ganglia may support this encoding operation by executive and binding processes within working memory, and the posterior parahippocampal region may play a role in binding and memory formation. (c) 2007 Elsevier Inc. All rights reserved.
关键词episodic memory hippocampus medial temporal lobe prefrontal cortex discontinuous association simultaneous association
学科领域认知神经科学
收录类别SCI
语种英语
WOS记录号WOS:000249992900021
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5633
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者J. Luo; G. Fernandez
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Radboud Univ Nijmegen, FC Donders Ctr Cognit Neuroimaging, NL-6500 HB Nijmegen, Netherlands
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Univ Utrecht, Helmholtz Inst, NL-3584 CS Utrecht, Netherlands
5.Univ Med Ctr Nijmegen, Dept Neurol, NL-6500 HB Nijmegen, Netherlands
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Qin, Shaozheng,Piekema, Carinne,Petersson, Karl Magnus,et al. Probing the transformation of discontinuous associations into episodic memory: An event-related fMRI study[J]. NEUROIMAGE,2007,38(1):212-222.
APA Qin, Shaozheng.,Piekema, Carinne.,Petersson, Karl Magnus.,Han, Buxin.,Luo, Jing.,...&G. Fernandez.(2007).Probing the transformation of discontinuous associations into episodic memory: An event-related fMRI study.NEUROIMAGE,38(1),212-222.
MLA Qin, Shaozheng,et al."Probing the transformation of discontinuous associations into episodic memory: An event-related fMRI study".NEUROIMAGE 38.1(2007):212-222.
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