Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats
	Shao, Feng 2; Jin, Jian 2; Meng, Qingxuan 2; Liu, Mei 2; Xie, Xi1 ; Lin, Wenjuan1 ; Wang, Weiwen1 ; W. W. Wang
摘要	Puberty is a critical period for neurodevelopment of schizophrenia. In the present study, we investigated the effects of peri-pubertal social isolation on psychotic behaviors in rats and its relationship to dopamine expression. Wistar male rats were randomly divided into pubertal isolation (ISO: isolate housing, 38-51 days of age) and social (SOC) groups. Latent inhibition (LI) and behavior in open field were tested during adolescence and adulthood. After the behavioral test, dopamine (DA) levels were measured in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC), caudate-putamen (CPU), and the hippocampus (HIP). Pubertal social isolation impaired LI and increased the DA level in the NAC of young adult rats, but not adolescent rats, and enhanced open field locomotor activity in both adolescent and young adult rats. These data suggest that development of an LI deficit can be induced by social isolation during puberty after a developmental delay, and that NAC DA maybe involved in this process, which may mirror some aspects of the ontogency of schizophrenic symptoms.; Puberty is a critical period for neurodevelopment of schizophrenia. In the present study, we investigated the effects of peri-pubertal social isolation on psychotic behaviors in rats and its relationship to dopamine expression. Wistar male rats were randomly divided into pubertal isolation (ISO: isolate housing, 38-51 days of age) and social (SOC) groups. Latent inhibition (LI) and behavior in open field were tested during adolescence and adulthood. After the behavioral test, dopamine (DA) levels were measured in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC), caudate-putamen (CPU), and the hippocampus (HIP). Pubertal social isolation impaired LI and increased the DA level in the NAC of young adult rats, but not adolescent rats, and enhanced open field locomotor activity in both adolescent and young adult rats. These data suggest that development of an LI deficit can be induced by social isolation during puberty after a developmental delay, and that NAC DA maybe involved in this process, which may mirror some aspects of the ontogency of schizophrenic symptoms. (c) 2009 Elsevier Inc. All rights reserved.
关键词	Social isolation Puberty Schizophrenia Latent inhibition Open field DA Nucleus accumbens
学科领域	生理心理学/生物心理学
	2009-09-07
语种	英语
发表期刊	PHYSIOLOGY & BEHAVIOR
ISSN	0031-9384
卷号	98 期号:3 页码:251-257
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS记录号	WOS:000269571600001
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5649
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	W. W. Wang
作者单位	1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Shao, Feng,Jin, Jian,Meng, Qingxuan,et al. Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats[J]. PHYSIOLOGY & BEHAVIOR,2009,98(3):251-257.
APA	Shao, Feng.,Jin, Jian.,Meng, Qingxuan.,Liu, Mei.,Xie, Xi.,...&W. W. Wang.(2009).Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats.PHYSIOLOGY & BEHAVIOR,98(3),251-257.
MLA	Shao, Feng,et al."Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats".PHYSIOLOGY & BEHAVIOR 98.3(2009):251-257.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Shao-2009-Pubertal i（613KB）			开放获取	--	浏览下载