Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats
Shao, Feng2; Jin, Jian2; Meng, Qingxuan2; Liu, Mei2; Xie, Xi1; Lin, Wenjuan1; Wang, Weiwen1; W. W. Wang
2009-09-07
发表期刊PHYSIOLOGY & BEHAVIOR
ISSN0031-9384
文章类型Article
卷号98期号:3页码:251-257
摘要Puberty is a critical period for neurodevelopment of schizophrenia. In the present study, we investigated the effects of peri-pubertal social isolation on psychotic behaviors in rats and its relationship to dopamine expression. Wistar male rats were randomly divided into pubertal isolation (ISO: isolate housing, 38-51 days of age) and social (SOC) groups. Latent inhibition (LI) and behavior in open field were tested during adolescence and adulthood. After the behavioral test, dopamine (DA) levels were measured in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC), caudate-putamen (CPU), and the hippocampus (HIP). Pubertal social isolation impaired LI and increased the DA level in the NAC of young adult rats, but not adolescent rats, and enhanced open field locomotor activity in both adolescent and young adult rats. These data suggest that development of an LI deficit can be induced by social isolation during puberty after a developmental delay, and that NAC DA maybe involved in this process, which may mirror some aspects of the ontogency of schizophrenic symptoms.; Puberty is a critical period for neurodevelopment of schizophrenia. In the present study, we investigated the effects of peri-pubertal social isolation on psychotic behaviors in rats and its relationship to dopamine expression. Wistar male rats were randomly divided into pubertal isolation (ISO: isolate housing, 38-51 days of age) and social (SOC) groups. Latent inhibition (LI) and behavior in open field were tested during adolescence and adulthood. After the behavioral test, dopamine (DA) levels were measured in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC), caudate-putamen (CPU), and the hippocampus (HIP). Pubertal social isolation impaired LI and increased the DA level in the NAC of young adult rats, but not adolescent rats, and enhanced open field locomotor activity in both adolescent and young adult rats. These data suggest that development of an LI deficit can be induced by social isolation during puberty after a developmental delay, and that NAC DA maybe involved in this process, which may mirror some aspects of the ontogency of schizophrenic symptoms. (c) 2009 Elsevier Inc. All rights reserved.
关键词Social isolation Puberty Schizophrenia Latent inhibition Open field DA Nucleus accumbens
学科领域生理心理学/生物心理学
收录类别SCI ; SSCI
语种英语
WOS记录号WOS:000269571600001
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5649
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者W. W. Wang
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
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Shao, Feng,Jin, Jian,Meng, Qingxuan,et al. Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats[J]. PHYSIOLOGY & BEHAVIOR,2009,98(3):251-257.
APA Shao, Feng.,Jin, Jian.,Meng, Qingxuan.,Liu, Mei.,Xie, Xi.,...&W. W. Wang.(2009).Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats.PHYSIOLOGY & BEHAVIOR,98(3),251-257.
MLA Shao, Feng,et al."Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats".PHYSIOLOGY & BEHAVIOR 98.3(2009):251-257.
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