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Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats
Shao, Feng2; Jin, Jian2; Meng, Qingxuan2; Liu, Mei2; Xie, Xi1; Lin, Wenjuan1; Wang, Weiwen1; W. W. Wang
2009-09-07
Source PublicationPHYSIOLOGY & BEHAVIOR
ISSN0031-9384
SubtypeArticle
Volume98Issue:3Pages:251-257
AbstractPuberty is a critical period for neurodevelopment of schizophrenia. In the present study, we investigated the effects of peri-pubertal social isolation on psychotic behaviors in rats and its relationship to dopamine expression. Wistar male rats were randomly divided into pubertal isolation (ISO: isolate housing, 38-51 days of age) and social (SOC) groups. Latent inhibition (LI) and behavior in open field were tested during adolescence and adulthood. After the behavioral test, dopamine (DA) levels were measured in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC), caudate-putamen (CPU), and the hippocampus (HIP). Pubertal social isolation impaired LI and increased the DA level in the NAC of young adult rats, but not adolescent rats, and enhanced open field locomotor activity in both adolescent and young adult rats. These data suggest that development of an LI deficit can be induced by social isolation during puberty after a developmental delay, and that NAC DA maybe involved in this process, which may mirror some aspects of the ontogency of schizophrenic symptoms.; Puberty is a critical period for neurodevelopment of schizophrenia. In the present study, we investigated the effects of peri-pubertal social isolation on psychotic behaviors in rats and its relationship to dopamine expression. Wistar male rats were randomly divided into pubertal isolation (ISO: isolate housing, 38-51 days of age) and social (SOC) groups. Latent inhibition (LI) and behavior in open field were tested during adolescence and adulthood. After the behavioral test, dopamine (DA) levels were measured in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC), caudate-putamen (CPU), and the hippocampus (HIP). Pubertal social isolation impaired LI and increased the DA level in the NAC of young adult rats, but not adolescent rats, and enhanced open field locomotor activity in both adolescent and young adult rats. These data suggest that development of an LI deficit can be induced by social isolation during puberty after a developmental delay, and that NAC DA maybe involved in this process, which may mirror some aspects of the ontogency of schizophrenic symptoms. (c) 2009 Elsevier Inc. All rights reserved.
KeywordSocial isolation Puberty Schizophrenia Latent inhibition Open field DA Nucleus accumbens
Subject Area生理心理学/生物心理学
Indexed BySCI ; SSCI
Language英语
WOS IDWOS:000269571600001
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5649
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorW. W. Wang
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Shao, Feng,Jin, Jian,Meng, Qingxuan,et al. Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats[J]. PHYSIOLOGY & BEHAVIOR,2009,98(3):251-257.
APA Shao, Feng.,Jin, Jian.,Meng, Qingxuan.,Liu, Mei.,Xie, Xi.,...&W. W. Wang.(2009).Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats.PHYSIOLOGY & BEHAVIOR,98(3),251-257.
MLA Shao, Feng,et al."Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats".PHYSIOLOGY & BEHAVIOR 98.3(2009):251-257.
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