Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress
Guo, Jian-You2; Huo, Hai-Ru1; Li, Lan-Fang1; Guo, Shu-Ying1; Jiang, Ting-Liang1; H. R. Huo
2009
发表期刊AMERICAN JOURNAL OF CHINESE MEDICINE
ISSN0192-415X
文章类型Article
卷号37期号:2页码:261-272
摘要Sini Tang, a Chinese traditional prescription containing three herbs, has been widely used for Yang-deficiency. Recent clinical studies have shown that Sini Tang could treat and improve depression symptoms, but the mechanisms underlying the antidepressant effect of Sini Tang remains unknown. In rats with chronic unpredictable stress (CUS), we examined the effects of Sini Tang on sucrose preference and open field exploratory behavior. The levels of corticosterone level in plasma and corticotropin-releasing hormone (CRH) mRNA expression in hypothalamus were also measured by enzyme-linked immunosorbent assays (ELISA) and real-time reverse transcription PCR (RT-PCR), respectively. Rats subjected to CUS exhibited decreases in sucrose preference and ambulation in the open field test. These were all attenuated by Sini Tang in a dose-dependent manner. Biochemically, Sini Tang also reversed CUS-induced increases in corticosterone in plasma and CRH mRNA in the hypothalamus. The behavioral effects of the Sini Tang were correlated to the biochemical actions. These results suggest that Sini Tang produces an antidepressant-like effect, which appears to involve CRH in the brain.; Sini Tang, a Chinese traditional prescription containing three herbs, has been widely used for Yang-deficiency. Recent clinical studies have shown that Sini Tang could treat and improve depression symptoms, but the mechanisms underlying the antidepressant effect of Sini Tang remains unknown. In rats with chronic unpredictable stress (CUS), we examined the effects of Sini Tang on sucrose preference and open field exploratory behavior. The levels of corticosterone level in plasma and corticotropin-releasing hormone (CRH) mRNA expression in hypothalamus were also measured by enzyme-linked immunosorbent assays (ELISA) and real-time reverse transcription PCR (RT-PCR), respectively. Rats subjected to CUS exhibited decreases in sucrose preference and ambulation in the open field test. These were all attenuated by Sini Tang in a dose-dependent manner. Biochemically, Sini Tang also reversed CUS-induced increases in corticosterone in plasma and CRH mRNA in the hypothalamus. The behavioral effects of the Sini Tang were correlated to the biochemical actions. These results suggest that Sini Tang produces an antidepressant-like effect, which appears to involve CRH in the brain.
关键词Depression Chronic Unpredictable Stress Corticotropin-releasing Hormone Corticosterone Radix aconiti lateralis preparata Rhizoma zingiberis recens Leguminosae
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000265207300006
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5689
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者H. R. Huo
作者单位1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Tang Ctr Herbal Med Res, Beijing 100700, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Guo, Jian-You,Huo, Hai-Ru,Li, Lan-Fang,et al. Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2009,37(2):261-272.
APA Guo, Jian-You,Huo, Hai-Ru,Li, Lan-Fang,Guo, Shu-Ying,Jiang, Ting-Liang,&H. R. Huo.(2009).Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress.AMERICAN JOURNAL OF CHINESE MEDICINE,37(2),261-272.
MLA Guo, Jian-You,et al."Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress".AMERICAN JOURNAL OF CHINESE MEDICINE 37.2(2009):261-272.
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