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Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress
Guo, Jian-You2; Huo, Hai-Ru1; Li, Lan-Fang1; Guo, Shu-Ying1; Jiang, Ting-Liang1; H. R. Huo
2009
Source PublicationAMERICAN JOURNAL OF CHINESE MEDICINE
ISSN0192-415X
SubtypeArticle
Volume37Issue:2Pages:261-272
AbstractSini Tang, a Chinese traditional prescription containing three herbs, has been widely used for Yang-deficiency. Recent clinical studies have shown that Sini Tang could treat and improve depression symptoms, but the mechanisms underlying the antidepressant effect of Sini Tang remains unknown. In rats with chronic unpredictable stress (CUS), we examined the effects of Sini Tang on sucrose preference and open field exploratory behavior. The levels of corticosterone level in plasma and corticotropin-releasing hormone (CRH) mRNA expression in hypothalamus were also measured by enzyme-linked immunosorbent assays (ELISA) and real-time reverse transcription PCR (RT-PCR), respectively. Rats subjected to CUS exhibited decreases in sucrose preference and ambulation in the open field test. These were all attenuated by Sini Tang in a dose-dependent manner. Biochemically, Sini Tang also reversed CUS-induced increases in corticosterone in plasma and CRH mRNA in the hypothalamus. The behavioral effects of the Sini Tang were correlated to the biochemical actions. These results suggest that Sini Tang produces an antidepressant-like effect, which appears to involve CRH in the brain.; Sini Tang, a Chinese traditional prescription containing three herbs, has been widely used for Yang-deficiency. Recent clinical studies have shown that Sini Tang could treat and improve depression symptoms, but the mechanisms underlying the antidepressant effect of Sini Tang remains unknown. In rats with chronic unpredictable stress (CUS), we examined the effects of Sini Tang on sucrose preference and open field exploratory behavior. The levels of corticosterone level in plasma and corticotropin-releasing hormone (CRH) mRNA expression in hypothalamus were also measured by enzyme-linked immunosorbent assays (ELISA) and real-time reverse transcription PCR (RT-PCR), respectively. Rats subjected to CUS exhibited decreases in sucrose preference and ambulation in the open field test. These were all attenuated by Sini Tang in a dose-dependent manner. Biochemically, Sini Tang also reversed CUS-induced increases in corticosterone in plasma and CRH mRNA in the hypothalamus. The behavioral effects of the Sini Tang were correlated to the biochemical actions. These results suggest that Sini Tang produces an antidepressant-like effect, which appears to involve CRH in the brain.
KeywordDepression Chronic Unpredictable Stress Corticotropin-releasing Hormone Corticosterone Radix aconiti lateralis preparata Rhizoma zingiberis recens Leguminosae
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000265207300006
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5689
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorH. R. Huo
Affiliation1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Tang Ctr Herbal Med Res, Beijing 100700, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Guo, Jian-You,Huo, Hai-Ru,Li, Lan-Fang,et al. Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2009,37(2):261-272.
APA Guo, Jian-You,Huo, Hai-Ru,Li, Lan-Fang,Guo, Shu-Ying,Jiang, Ting-Liang,&H. R. Huo.(2009).Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress.AMERICAN JOURNAL OF CHINESE MEDICINE,37(2),261-272.
MLA Guo, Jian-You,et al."Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress".AMERICAN JOURNAL OF CHINESE MEDICINE 37.2(2009):261-272.
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