Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine
Zheng, XG; Li, YH; Luo, XJ; Xiao, L; Wang, DM; Liu, J; Yang, XY; Sui, N; N. Sui
摘要Large individual differences have been identified toward varied addictive effects as evidenced in self-administration, place conditioning, and psychomotor stimulation paradiams, which have been primarily attributed to the role of congenital factors. However, it remains unknown whether environmental factors, like extraneous social stress events, could distinctively modulate animals with differentiated biobehavioral traits, such as rats with higher motor activity (high responder, HR) developed in a novel environment and their counterparts, LR (low responder) rats. In the present study, the influence of social crowding procedure upon morphine psychomotor effect was investigated. Moreover, the roles social stress played, respectively, on HRs and LRs were explored based on previous observation that HRs not only responded more to drugs but also to stress. Our results revealed that social crowding procedure could sensitize morphine psychomotor effect as a whole, and this effect was only evident for HR but not LR rats. The individual differences toward morphine psychornotor effects was indiscernible in rats housed in normal social conditions and only turned out to be significant under stress conditions. Given the fact that the occurrence of human addictive behavior usually happens within social environment permeated with various stress factors, the genetic and environmental elements may collaboratively contribute to the ultimate susceptibility of drug-prone individuals.; Large individual differences have been identified toward varied addictive effects as evidenced in self-administration, place conditioning, and psychomotor stimulation paradiams, which have been primarily attributed to the role of congenital factors. However, it remains unknown whether environmental factors, like extraneous social stress events, could distinctively modulate animals with differentiated biobehavioral traits, such as rats with higher motor activity (high responder, HR) developed in a novel environment and their counterparts, LR (low responder) rats. In the present study, the influence of social crowding procedure upon morphine psychomotor effect was investigated. Moreover, the roles social stress played, respectively, on HRs and LRs were explored based on previous observation that HRs not only responded more to drugs but also to stress. Our results revealed that social crowding procedure could sensitize morphine psychomotor effect as a whole, and this effect was only evident for HR but not LR rats. The individual differences toward morphine psychornotor effects was indiscernible in rats housed in normal social conditions and only turned out to be significant under stress conditions. Given the fact that the occurrence of human addictive behavior usually happens within social environment permeated with various stress factors, the genetic and environmental elements may collaboratively contribute to the ultimate susceptibility of drug-prone individuals. (C) 2004 Elsevier Inc. All rights reserved.
关键词susceptibility morphine psychomotor sensitization social crowding individual differences
学科领域医学心理学
2004-10-01
语种英语
发表期刊PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN0091-3057
卷号79期号:2页码:213-218
期刊论文类型Article
收录类别SCI
WOS记录号WOS:000225045300002
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5691
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者N. Sui
作者单位Acad Sinica, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zheng, XG,Li, YH,Luo, XJ,et al. Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2004,79(2):213-218.
APA Zheng, XG.,Li, YH.,Luo, XJ.,Xiao, L.,Wang, DM.,...&N. Sui.(2004).Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,79(2),213-218.
MLA Zheng, XG,et al."Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 79.2(2004):213-218.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Zheng-2004-Social cr(213KB) 开放获取--浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zheng, XG]的文章
[Li, YH]的文章
[Luo, XJ]的文章
百度学术
百度学术中相似的文章
[Zheng, XG]的文章
[Li, YH]的文章
[Luo, XJ]的文章
必应学术
必应学术中相似的文章
[Zheng, XG]的文章
[Li, YH]的文章
[Luo, XJ]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Zheng-2004-Social crowding sens.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。