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Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine
Zheng, XG; Li, YH; Luo, XJ; Xiao, L; Wang, DM; Liu, J; Yang, XY; Sui, N; N. Sui
2004-10-01
Source PublicationPHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN0091-3057
SubtypeArticle
Volume79Issue:2Pages:213-218
AbstractLarge individual differences have been identified toward varied addictive effects as evidenced in self-administration, place conditioning, and psychomotor stimulation paradiams, which have been primarily attributed to the role of congenital factors. However, it remains unknown whether environmental factors, like extraneous social stress events, could distinctively modulate animals with differentiated biobehavioral traits, such as rats with higher motor activity (high responder, HR) developed in a novel environment and their counterparts, LR (low responder) rats. In the present study, the influence of social crowding procedure upon morphine psychomotor effect was investigated. Moreover, the roles social stress played, respectively, on HRs and LRs were explored based on previous observation that HRs not only responded more to drugs but also to stress. Our results revealed that social crowding procedure could sensitize morphine psychomotor effect as a whole, and this effect was only evident for HR but not LR rats. The individual differences toward morphine psychornotor effects was indiscernible in rats housed in normal social conditions and only turned out to be significant under stress conditions. Given the fact that the occurrence of human addictive behavior usually happens within social environment permeated with various stress factors, the genetic and environmental elements may collaboratively contribute to the ultimate susceptibility of drug-prone individuals.; Large individual differences have been identified toward varied addictive effects as evidenced in self-administration, place conditioning, and psychomotor stimulation paradiams, which have been primarily attributed to the role of congenital factors. However, it remains unknown whether environmental factors, like extraneous social stress events, could distinctively modulate animals with differentiated biobehavioral traits, such as rats with higher motor activity (high responder, HR) developed in a novel environment and their counterparts, LR (low responder) rats. In the present study, the influence of social crowding procedure upon morphine psychomotor effect was investigated. Moreover, the roles social stress played, respectively, on HRs and LRs were explored based on previous observation that HRs not only responded more to drugs but also to stress. Our results revealed that social crowding procedure could sensitize morphine psychomotor effect as a whole, and this effect was only evident for HR but not LR rats. The individual differences toward morphine psychornotor effects was indiscernible in rats housed in normal social conditions and only turned out to be significant under stress conditions. Given the fact that the occurrence of human addictive behavior usually happens within social environment permeated with various stress factors, the genetic and environmental elements may collaboratively contribute to the ultimate susceptibility of drug-prone individuals. (C) 2004 Elsevier Inc. All rights reserved.
Keywordsusceptibility morphine psychomotor sensitization social crowding individual differences
Subject Area医学心理学
Indexed BySCI
Language英语
WOS IDWOS:000225045300002
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5691
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorN. Sui
AffiliationAcad Sinica, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zheng, XG,Li, YH,Luo, XJ,et al. Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2004,79(2):213-218.
APA Zheng, XG.,Li, YH.,Luo, XJ.,Xiao, L.,Wang, DM.,...&N. Sui.(2004).Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,79(2),213-218.
MLA Zheng, XG,et al."Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 79.2(2004):213-218.
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