Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease

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	Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease
	Chang, Jing-Yu 1; Shi, Li-Hong 2; Luo, Fei3 ; Zhang, Wang-Ming 4; Woodward, Donald J.1; J. Y. Chang
摘要	Several rodent models of deep brain stimulation (DBS) have been developed in recent years. Electrophysiological and neurochemical studies have been performed to examine the mechanisms underlying the effects of DBS. In vitro studies have provided deep insights into the role of ion channels in response to brain stimulation. In vivo studies reveal neural responses in the context of intact neural circuits. Most importantly, recording of neural responses to behaviorally effective DBS in freely moving animals provides a direct means for examining how DBS modulates the basal ganglia thalamocortical circuits and thereby improves motor function. DBS can modulate firing rate, normalize irregular burst firing patterns and reduce low frequency oscillations associated with the Parkinsonian state. Our current efforts are focused on elucidating the mechanisms by which DBS effects on neural circuitry improve motor performance. New behavioral models and improved recording techniques will aide researchers conducting future DBS studies in a variety of behavioral modalities and enable new treatment strategies to be explored, such as closed-loop stimulations based on real time computation of ensemble neural activity.; Several rodent models of deep brain stimulation (DBS) have been developed in recent years. Electrophysiological and neurochemical studies have been performed to examine the mechanisms underlying the effects of DBS. In vitro studies have provided deep insights into the role of ion channels in response to brain stimulation. In vivo studies reveal neural responses in the context of intact neural circuits. Most importantly, recording of neural responses to behaviorally effective DBS in freely moving animals provides a direct means for examining how DBS modulates the basal ganglia thalamocortical circuits and thereby improves motor function. DBS can modulate firing rate, normalize irregular burst firing patterns and reduce low frequency oscillations associated with the Parkinsonian state. Our current efforts are focused on elucidating the mechanisms by which DBS effects on neural circuitry improve motor performance. New behavioral models and improved recording techniques will aide researchers conducting future DBS studies in a variety of behavioral modalities and enable new treatment strategies to be explored, such as closed-loop stimulations based on real time computation of ensemble neural activity. (c) 2007 Elsevier Ltd. All rights reserved.
关键词	deep brain stimulation Parkinson's disease basal ganglia subthalamic nucleus animal models neurological disorders
学科领域	认知神经科学
	2008
语种	英语
发表期刊	NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
ISSN	0149-7634
卷号	32 期号:3 页码:352-366
期刊论文类型	Review
收录类别	SCI
WOS记录号	WOS:000253400600004
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5705
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	J. Y. Chang
作者单位	1.Neurosci Res Inst N Carolina, Winston Salem, NC 27101 USA 2.Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA 3.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 4.So Med Univ, Dept Neurosurg, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Chang, Jing-Yu,Shi, Li-Hong,Luo, Fei,et al. Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2008,32(3):352-366.
APA	Chang, Jing-Yu,Shi, Li-Hong,Luo, Fei,Zhang, Wang-Ming,Woodward, Donald J.,&J. Y. Chang.(2008).Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,32(3),352-366.
MLA	Chang, Jing-Yu,et al."Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 32.3(2008):352-366.

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