Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease
Chang, Jing-Yu1; Shi, Li-Hong2; Luo, Fei3; Zhang, Wang-Ming4; Woodward, Donald J.1; J. Y. Chang
2008
发表期刊NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
ISSN0149-7634
文章类型Review
卷号32期号:3页码:352-366
摘要Several rodent models of deep brain stimulation (DBS) have been developed in recent years. Electrophysiological and neurochemical studies have been performed to examine the mechanisms underlying the effects of DBS. In vitro studies have provided deep insights into the role of ion channels in response to brain stimulation. In vivo studies reveal neural responses in the context of intact neural circuits. Most importantly, recording of neural responses to behaviorally effective DBS in freely moving animals provides a direct means for examining how DBS modulates the basal ganglia thalamocortical circuits and thereby improves motor function. DBS can modulate firing rate, normalize irregular burst firing patterns and reduce low frequency oscillations associated with the Parkinsonian state. Our current efforts are focused on elucidating the mechanisms by which DBS effects on neural circuitry improve motor performance. New behavioral models and improved recording techniques will aide researchers conducting future DBS studies in a variety of behavioral modalities and enable new treatment strategies to be explored, such as closed-loop stimulations based on real time computation of ensemble neural activity.; Several rodent models of deep brain stimulation (DBS) have been developed in recent years. Electrophysiological and neurochemical studies have been performed to examine the mechanisms underlying the effects of DBS. In vitro studies have provided deep insights into the role of ion channels in response to brain stimulation. In vivo studies reveal neural responses in the context of intact neural circuits. Most importantly, recording of neural responses to behaviorally effective DBS in freely moving animals provides a direct means for examining how DBS modulates the basal ganglia thalamocortical circuits and thereby improves motor function. DBS can modulate firing rate, normalize irregular burst firing patterns and reduce low frequency oscillations associated with the Parkinsonian state. Our current efforts are focused on elucidating the mechanisms by which DBS effects on neural circuitry improve motor performance. New behavioral models and improved recording techniques will aide researchers conducting future DBS studies in a variety of behavioral modalities and enable new treatment strategies to be explored, such as closed-loop stimulations based on real time computation of ensemble neural activity. (c) 2007 Elsevier Ltd. All rights reserved.
关键词deep brain stimulation Parkinson's disease basal ganglia subthalamic nucleus animal models neurological disorders
学科领域认知神经科学
收录类别SCI
语种英语
WOS记录号WOS:000253400600004
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5705
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者J. Y. Chang
作者单位1.Neurosci Res Inst N Carolina, Winston Salem, NC 27101 USA
2.Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA
3.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
4.So Med Univ, Dept Neurosurg, Guangzhou, Peoples R China
推荐引用方式
GB/T 7714
Chang, Jing-Yu,Shi, Li-Hong,Luo, Fei,et al. Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2008,32(3):352-366.
APA Chang, Jing-Yu,Shi, Li-Hong,Luo, Fei,Zhang, Wang-Ming,Woodward, Donald J.,&J. Y. Chang.(2008).Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,32(3),352-366.
MLA Chang, Jing-Yu,et al."Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 32.3(2008):352-366.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Chang-2008-Studies o(529KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chang, Jing-Yu]的文章
[Shi, Li-Hong]的文章
[Luo, Fei]的文章
百度学术
百度学术中相似的文章
[Chang, Jing-Yu]的文章
[Shi, Li-Hong]的文章
[Luo, Fei]的文章
必应学术
必应学术中相似的文章
[Chang, Jing-Yu]的文章
[Shi, Li-Hong]的文章
[Luo, Fei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。