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The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation
Wang, Yan1,2,3; Zhang, Ming2,3; Moon, Changjong4; Hu, Qubai5; Wang, Baiping5; Martin, George5; Sun, Zhongsheng1; Wang, Hongbing2,3; Z. S. Sun
2009-09-01
Source PublicationLEARNING & MEMORY
ISSN1072-0502
SubtypeArticle
Volume16Issue:9Pages:537-544
AbstractFE65 is expressed predominantly in the brain and interacts with the C-terminal domain of beta-amyloid precursor protein (APP). We examined hippocampus-dependent memory and in vivo long-term potentiation (LTP) at the CA1 synapses with isoform-specific FE65 knockout (p97FE65(-/-)) mice. When examined using the Morris water maze, p97FE65(-/-) mice were impaired for the hidden platform task but showed normal performance in the probe test. To further discriminate the role of FE65 in acquisition and memory consolidation, we examined p97FE65(-/-) mice with temporal dissociative passive avoidance (TDPA) and contextual fear conditioning (CFC). p97FE65(-/-) mice showed impaired short-term memory for both TDPA and CFC when tested 10 min after training. After multiple TDPA training sessions, the crossover latency of some p97FE65(--) mice reached the cutoff value, but it significantly decayed in 8 d. At the Schaffer collateral-CA1 synapses, p97FE65(--) mice showed defective early-phase LTP (E-LTP). These results demonstrate novel roles of FE65 in synaptic plasticity, acquisition, and retention for certain forms of memory formation.; FE65 is expressed predominantly in the brain and interacts with the C-terminal domain of beta-amyloid precursor protein (APP). We examined hippocampus-dependent memory and in vivo long-term potentiation (LTP) at the CA1 synapses with isoform-specific FE65 knockout (p97FE65(-/-)) mice. When examined using the Morris water maze, p97FE65(-/-) mice were impaired for the hidden platform task but showed normal performance in the probe test. To further discriminate the role of FE65 in acquisition and memory consolidation, we examined p97FE65(-/-) mice with temporal dissociative passive avoidance (TDPA) and contextual fear conditioning (CFC). p97FE65(-/-) mice showed impaired short-term memory for both TDPA and CFC when tested 10 min after training. After multiple TDPA training sessions, the crossover latency of some p97FE65(-/-) mice reached the cutoff value, but it significantly decayed in 8 d. At the Schaffer collateral-CA1 synapses, p97FE65(-/-) mice showed defective early-phase LTP (E-LTP). These results demonstrate novel roles of FE65 in synaptic plasticity, acquisition, and retention for certain forms of memory formation.
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000270368300005
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5733
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorZ. S. Sun
Affiliation1.Chinese Acad Sci, Behav Genet Ctr, Inst Psychol, Beijing 100101, Peoples R China
2.Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA
3.Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA
4.Chonnam Natl Univ, Coll Vet Med, Dept Vet Anat, Kwangju 500757, South Korea
5.Univ Washington, Dept Pathol, Seattle, WA 98195 USA
Recommended Citation
GB/T 7714
Wang, Yan,Zhang, Ming,Moon, Changjong,et al. The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation[J]. LEARNING & MEMORY,2009,16(9):537-544.
APA Wang, Yan.,Zhang, Ming.,Moon, Changjong.,Hu, Qubai.,Wang, Baiping.,...&Z. S. Sun.(2009).The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation.LEARNING & MEMORY,16(9),537-544.
MLA Wang, Yan,et al."The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation".LEARNING & MEMORY 16.9(2009):537-544.
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