The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation

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	The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation
	Wang, Yan 1,2,3; Zhang, Ming 2,3; Moon, Changjong 4; Hu, Qubai 5; Wang, Baiping 5; Martin, George 5; Sun, Zhongsheng 1; Wang, Hongbing 2,3; Z. S. Sun
摘要	FE65 is expressed predominantly in the brain and interacts with the C-terminal domain of beta-amyloid precursor protein (APP). We examined hippocampus-dependent memory and in vivo long-term potentiation (LTP) at the CA1 synapses with isoform-specific FE65 knockout (p97FE65(-/-)) mice. When examined using the Morris water maze, p97FE65(-/-) mice were impaired for the hidden platform task but showed normal performance in the probe test. To further discriminate the role of FE65 in acquisition and memory consolidation, we examined p97FE65(-/-) mice with temporal dissociative passive avoidance (TDPA) and contextual fear conditioning (CFC). p97FE65(-/-) mice showed impaired short-term memory for both TDPA and CFC when tested 10 min after training. After multiple TDPA training sessions, the crossover latency of some p97FE65(--) mice reached the cutoff value, but it significantly decayed in 8 d. At the Schaffer collateral-CA1 synapses, p97FE65(--) mice showed defective early-phase LTP (E-LTP). These results demonstrate novel roles of FE65 in synaptic plasticity, acquisition, and retention for certain forms of memory formation.; FE65 is expressed predominantly in the brain and interacts with the C-terminal domain of beta-amyloid precursor protein (APP). We examined hippocampus-dependent memory and in vivo long-term potentiation (LTP) at the CA1 synapses with isoform-specific FE65 knockout (p97FE65(-/-)) mice. When examined using the Morris water maze, p97FE65(-/-) mice were impaired for the hidden platform task but showed normal performance in the probe test. To further discriminate the role of FE65 in acquisition and memory consolidation, we examined p97FE65(-/-) mice with temporal dissociative passive avoidance (TDPA) and contextual fear conditioning (CFC). p97FE65(-/-) mice showed impaired short-term memory for both TDPA and CFC when tested 10 min after training. After multiple TDPA training sessions, the crossover latency of some p97FE65(-/-) mice reached the cutoff value, but it significantly decayed in 8 d. At the Schaffer collateral-CA1 synapses, p97FE65(-/-) mice showed defective early-phase LTP (E-LTP). These results demonstrate novel roles of FE65 in synaptic plasticity, acquisition, and retention for certain forms of memory formation.
学科领域	生理心理学/生物心理学
	2009-09-01
语种	英语
发表期刊	LEARNING & MEMORY
ISSN	1072-0502
卷号	16 期号:9 页码:537-544
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000270368300005
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5733
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Z. S. Sun
作者单位	1.Chinese Acad Sci, Behav Genet Ctr, Inst Psychol, Beijing 100101, Peoples R China 2.Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA 3.Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA 4.Chonnam Natl Univ, Coll Vet Med, Dept Vet Anat, Kwangju 500757, South Korea 5.Univ Washington, Dept Pathol, Seattle, WA 98195 USA
推荐引用方式 GB/T 7714	Wang, Yan,Zhang, Ming,Moon, Changjong,et al. The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation[J]. LEARNING & MEMORY,2009,16(9):537-544.
APA	Wang, Yan.,Zhang, Ming.,Moon, Changjong.,Hu, Qubai.,Wang, Baiping.,...&Z. S. Sun.(2009).The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation.LEARNING & MEMORY,16(9),537-544.
MLA	Wang, Yan,et al."The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation".LEARNING & MEMORY 16.9(2009):537-544.

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