The effect of emotional stress on the primary humoral immunity of rats
Shao, F; Lin, WJ; Wang, WW; Washington, WC; Zheng, L
2003-06-01
发表期刊JOURNAL OF PSYCHOPHARMACOLOGY
ISSN0269-8811
文章类型Article
卷号17期号:2页码:179-183
摘要

The effect of exposure to emotional stress on humoral immune function after injection with ovalbumin, a novel antigen, was studied in adult male Wistar rats. Emotional stress was induced by randomly giving empty water bottles to rats trained to drink water at set times. The results showed that emotional stress induced the decrease in spleen weight and specific immunoglobulin G antibody level to ovalbumin, and increased levels of epinephrine, norepinephrine and corticosterone. A decrease of antibody levels correlated negatively with an increase in plasma norepinephrine levels. These findings suggest that emotional stress can modulate immune function, and that sympathetic nervous system may be involved in this immunomodulation.

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The effect of exposure to emotional stress on humoral immune function after injection with ovalbumin, a novel antigen, was studied in adult male Wistar rats. Emotional stress was induced by randomly giving empty water bottles to rats trained to drink water at set times. The results showed that emotional stress induced the decrease in spleen weight and specific immunoglobulin G antibody level to ovalbumin, and increased levels of epinephrine, norepinephrine and corticosterone. A decrease of antibody levels correlated negatively with an increase in plasma norepinephrine levels. These findings suggest that emotional stress can modulate immune function, and that sympathetic nervous system may be involved in this immunomodulation.

关键词antibody emotional stress empty water bottles immunomodulation sympathetic nervous system
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000183624700005
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5747
专题中国科学院心理研究所回溯数据库(1956-2010)
作者单位1.Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China
2.Peking Univ, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Shao, F,Lin, WJ,Wang, WW,et al. The effect of emotional stress on the primary humoral immunity of rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2003,17(2):179-183.
APA Shao, F,Lin, WJ,Wang, WW,Washington, WC,&Zheng, L.(2003).The effect of emotional stress on the primary humoral immunity of rats.JOURNAL OF PSYCHOPHARMACOLOGY,17(2),179-183.
MLA Shao, F,et al."The effect of emotional stress on the primary humoral immunity of rats".JOURNAL OF PSYCHOPHARMACOLOGY 17.2(2003):179-183.
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