The effect of emotional stress on the primary humoral immunity of rats

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	The effect of emotional stress on the primary humoral immunity of rats
	Shao, F ; Lin, WJ; Wang, WW; Washington, WC ; Zheng, L
摘要	The effect of exposure to emotional stress on humoral immune function after injection with ovalbumin, a novel antigen, was studied in adult male Wistar rats. Emotional stress was induced by randomly giving empty water bottles to rats trained to drink water at set times. The results showed that emotional stress induced the decrease in spleen weight and specific immunoglobulin G antibody level to ovalbumin, and increased levels of epinephrine, norepinephrine and corticosterone. A decrease of antibody levels correlated negatively with an increase in plasma norepinephrine levels. These findings suggest that emotional stress can modulate immune function, and that sympathetic nervous system may be involved in this immunomodulation. ; The effect of exposure to emotional stress on humoral immune function after injection with ovalbumin, a novel antigen, was studied in adult male Wistar rats. Emotional stress was induced by randomly giving empty water bottles to rats trained to drink water at set times. The results showed that emotional stress induced the decrease in spleen weight and specific immunoglobulin G antibody level to ovalbumin, and increased levels of epinephrine, norepinephrine and corticosterone. A decrease of antibody levels correlated negatively with an increase in plasma norepinephrine levels. These findings suggest that emotional stress can modulate immune function, and that sympathetic nervous system may be involved in this immunomodulation.
关键词	antibody emotional stress empty water bottles immunomodulation sympathetic nervous system
学科领域	生理心理学/生物心理学
	2003-06-01
语种	英语
发表期刊	JOURNAL OF PSYCHOPHARMACOLOGY
ISSN	0269-8811
卷号	17 期号:2 页码:179-183
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000183624700005
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5747
专题	中国科学院心理研究所回溯数据库(1956-2010)
作者单位	1.Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China 2.Peking Univ, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Shao, F,Lin, WJ,Wang, WW,et al. The effect of emotional stress on the primary humoral immunity of rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2003,17(2):179-183.
APA	Shao, F,Lin, WJ,Wang, WW,Washington, WC,&Zheng, L.(2003).The effect of emotional stress on the primary humoral immunity of rats.JOURNAL OF PSYCHOPHARMACOLOGY,17(2),179-183.
MLA	Shao, F,et al."The effect of emotional stress on the primary humoral immunity of rats".JOURNAL OF PSYCHOPHARMACOLOGY 17.2(2003):179-183.

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