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The effects of corn silk on glycaemic metabolism
Guo, Jianyou2; Liu, Tongjun3; Han, Linna4; Liu, Yongmei1; Y. M. Liu
2009-11-23
Source PublicationNUTRITION & METABOLISM
ISSN1743-7075
SubtypeArticle
Volume6
AbstractBackground: Corn silk contains proteins, vitamins, carbohydrates, Ca, K, Mg and Na salts, fixed and volatile oils, steroids such as sitosterol and stigmasterol, alkaloids, saponins, tannins, and flavonoids. Base on folk remedies, corn silk has been used as an oral antidiabetic agent in China for decades. However, the hypoglycemic activity of it has not yet been understood in terms of modern pharmacological concepts. The purpose of this study is to investigate the effects of corn silk on glycaemic metabolism. Methods: Alloxan and adrenalin induced hyperglycemic mice were used in the study. The effects of corn silk on blood glucose, glycohemoglobin (HbA1c), insulin secretion, damaged pancreatic beta-cells, hepatic glycogen and gluconeogenesis in hyperglycemic mice were studied respectively. Results: After the mice were orally administered with corn silk extract, the blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic mice (p < 0.05, p < 0.01, respectively), while the level of insulin secretionn was markedly elevated in alloxa-induced hyperglycemic mice (p < 0.05). The alloxan-damaged pancreatic beta-cells of the mice were partly recovered gradually after the mice were administered with corn silk extract 15 days later. Also, the body weight of the alloxan-induced hyperglycemic mice was increased gradually. However, ascension of blood glucose induced by adrenalin and gluconeogenesis induced by L-alanine were not inhibited by corn silk extract treatment (p > 0.05). Although corn silk extract increased the level of hepatic glycogen in the alloxan-induced hyperglycemic mice, there was no significant difference between them and that of the control group(p > 0.05). Conclusion: Corn silk extract markedly reduced hyperglycemia in alloxan-induced diabetic mice. The action of corn silk extract on glycaemic metabolism is not via increasing glycogen and inhibiting gluconeogenesis but through increasing insulin level as well as recovering the injured beta-cells. The results suggest that corn silk extract may be used as a hypoglycemic food or medicine for hyperglycemic people in terms of this modern pharmacological study.; Background: Corn silk contains proteins, vitamins, carbohydrates, Ca, K, Mg and Na salts, fixed and volatile oils, steroids such as sitosterol and stigmasterol, alkaloids, saponins, tannins, and flavonoids. Base on folk remedies, corn silk has been used as an oral antidiabetic agent in China for decades. However, the hypoglycemic activity of it has not yet been understood in terms of modern pharmacological concepts. The purpose of this study is to investigate the effects of corn silk on glycaemic metabolism.
Keywordbeta-cell toxicity zea-mays volatiles transport extracts alloxan stigma dogs rats
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000272286400001
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5751
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorY. M. Liu
Affiliation1.China Acad Chinese Med Sci, Mol Biol Lab, Guanganmen Hosp, Beijing 100053, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Shandong Inst Light Ind, Coll Food & Bioengn, Jinan 250353, Peoples R China
4.Shandong Univ Tradit Chinese Med, Sch Pharm, Jinan 250355, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Guo, Jianyou,Liu, Tongjun,Han, Linna,et al. The effects of corn silk on glycaemic metabolism[J]. NUTRITION & METABOLISM,2009,6.
APA Guo, Jianyou,Liu, Tongjun,Han, Linna,Liu, Yongmei,&Y. M. Liu.(2009).The effects of corn silk on glycaemic metabolism.NUTRITION & METABOLISM,6.
MLA Guo, Jianyou,et al."The effects of corn silk on glycaemic metabolism".NUTRITION & METABOLISM 6(2009).
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