The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese
Qu, Yanchun1,2,3; Yang, Ze1; Jin, Feng4; Sun, Liang2; Feng, Jie1; Tang, Lei1; Zhang, Chuanfang2,3; Zhu, Xiaoquan1; Shi, Xiaohong1; Sun, Hong5; Wang, Binyou5; Wang, Li2; Z. Yang; L. Wang
2008-07-01
发表期刊DIABETES RESEARCH AND CLINICAL PRACTICE
ISSN0168-8227
文章类型Article
卷号81期号:1页码:33-37
摘要Leptin receptor (LEPR) plays an important physiological role in energy metabolism. The study addressed the relationship between leptin receptor gene variations and type 2 diabetes mellitus (T2DM). Three single nucleotide polymorphisms (SNPs) of LEPR gene, Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were detected in a northern population in China. Totally, 317 patients with T2DM and 282 healthy controls were recruited randomly from urban communities in Harbin area in the Northeast of China. All polymorphisms were genotyped by Sequenom SNP detection system in both case and control groups. Linkage disequilibria analysis showed moderate linkage disequilibria between the pair-wise SNPs for all three SNPs. Then, we identified the haplotype covering the three SNPs (AGC) with higher risk of T2DM (OR = 1.69 (1.09–2.61)), and showed that there existed significant difference between cases and controls (9.8% vs. 6.0%, P = 0.02). We also observed significant difference in frequencies of the heterozygous haplotype combination (GGT/AGC), that is 17.0% vs. 8.2% in cases and controls, respectively (P = 0.001). It further supported the evidence that the haplotype (AGC) was associated with T2DM. So, AGC haplotype in LEPR gene could be a risk factor associated with T2DM in Northern Chinese.; Leptin receptor (LEPR) plays an important physiological role in energy metabolism. The study addressed the relationship between leptin receptor gene variations and type 2 diabetes mellitus (T2DM). Three single nucleotide polymorphisms (SNPs) of LEPR gene, Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were detected in a northern population in China. Totally, 317 patients with T2DM and 282 healthy controls were recruited randomly from urban communities in Harbin area in the Northeast of China. All polymorphisms were genotyped by Sequenom SNP detection system in both case and control groups. Linkage disequilibria analysis showed moderate linkage disequilibria between the pair-wise SNPs for all three SNPs. Then, we identified the haplotype covering the three SNPs (AGC) with higher risk of T2DM (OR = 1.69 (1.09-2.61)), and showed that there existed significant difference between cases and controls (9.8% vs. 6.0%, P = 0.02). We also observed significant difference in frequencies of the heterozygous haplotype combination (GGT/AGC), that is 17.0% vs. 8.2% in cases and controls, respectively (P = 0.001). it further supported the evidence that the haplotype (AGC) was associated with T2DM. So, AGC haplotype in LEPR gene could be a risk factor associated with T2DM in Northern Chinese. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
关键词haplotype LEPR gene type 2 diabetes case-control
学科领域分子生物学
收录类别SCI
语种英语
WOS记录号WOS:000257567000006
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5763
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Z. Yang; L. Wang
作者单位1.Beijing Hosp, Minist Hlth, Natl Inst Geriatr, Beijing 100730, Peoples R China
2.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
5.Harbin Med Coll, Sch Publ Hlth, Harbin 150081, Peoples R China
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Qu, Yanchun,Yang, Ze,Jin, Feng,et al. The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2008,81(1):33-37.
APA Qu, Yanchun.,Yang, Ze.,Jin, Feng.,Sun, Liang.,Feng, Jie.,...&L. Wang.(2008).The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese.DIABETES RESEARCH AND CLINICAL PRACTICE,81(1),33-37.
MLA Qu, Yanchun,et al."The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese".DIABETES RESEARCH AND CLINICAL PRACTICE 81.1(2008):33-37.
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