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The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese
Qu, Yanchun1,2,3; Yang, Ze1; Jin, Feng4; Sun, Liang2; Feng, Jie1; Tang, Lei1; Zhang, Chuanfang2,3; Zhu, Xiaoquan1; Shi, Xiaohong1; Sun, Hong5; Wang, Binyou5; Wang, Li2; Z. Yang; L. Wang
AbstractLeptin receptor (LEPR) plays an important physiological role in energy metabolism. The study addressed the relationship between leptin receptor gene variations and type 2 diabetes mellitus (T2DM). Three single nucleotide polymorphisms (SNPs) of LEPR gene, Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were detected in a northern population in China. Totally, 317 patients with T2DM and 282 healthy controls were recruited randomly from urban communities in Harbin area in the Northeast of China. All polymorphisms were genotyped by Sequenom SNP detection system in both case and control groups. Linkage disequilibria analysis showed moderate linkage disequilibria between the pair-wise SNPs for all three SNPs. Then, we identified the haplotype covering the three SNPs (AGC) with higher risk of T2DM (OR = 1.69 (1.09–2.61)), and showed that there existed significant difference between cases and controls (9.8% vs. 6.0%, P = 0.02). We also observed significant difference in frequencies of the heterozygous haplotype combination (GGT/AGC), that is 17.0% vs. 8.2% in cases and controls, respectively (P = 0.001). It further supported the evidence that the haplotype (AGC) was associated with T2DM. So, AGC haplotype in LEPR gene could be a risk factor associated with T2DM in Northern Chinese.; Leptin receptor (LEPR) plays an important physiological role in energy metabolism. The study addressed the relationship between leptin receptor gene variations and type 2 diabetes mellitus (T2DM). Three single nucleotide polymorphisms (SNPs) of LEPR gene, Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were detected in a northern population in China. Totally, 317 patients with T2DM and 282 healthy controls were recruited randomly from urban communities in Harbin area in the Northeast of China. All polymorphisms were genotyped by Sequenom SNP detection system in both case and control groups. Linkage disequilibria analysis showed moderate linkage disequilibria between the pair-wise SNPs for all three SNPs. Then, we identified the haplotype covering the three SNPs (AGC) with higher risk of T2DM (OR = 1.69 (1.09-2.61)), and showed that there existed significant difference between cases and controls (9.8% vs. 6.0%, P = 0.02). We also observed significant difference in frequencies of the heterozygous haplotype combination (GGT/AGC), that is 17.0% vs. 8.2% in cases and controls, respectively (P = 0.001). it further supported the evidence that the haplotype (AGC) was associated with T2DM. So, AGC haplotype in LEPR gene could be a risk factor associated with T2DM in Northern Chinese. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Keywordhaplotype LEPR gene type 2 diabetes case-control
Subject Area分子生物学
2008-07-01
Language英语
Source PublicationDIABETES RESEARCH AND CLINICAL PRACTICE
ISSN0168-8227
Volume81Issue:1Pages:33-37
SubtypeArticle
Indexed BySCI
WOS IDWOS:000257567000006
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5763
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorZ. Yang; L. Wang
Affiliation1.Beijing Hosp, Minist Hlth, Natl Inst Geriatr, Beijing 100730, Peoples R China
2.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
5.Harbin Med Coll, Sch Publ Hlth, Harbin 150081, Peoples R China
Recommended Citation
GB/T 7714
Qu, Yanchun,Yang, Ze,Jin, Feng,et al. The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2008,81(1):33-37.
APA Qu, Yanchun.,Yang, Ze.,Jin, Feng.,Sun, Liang.,Feng, Jie.,...&L. Wang.(2008).The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese.DIABETES RESEARCH AND CLINICAL PRACTICE,81(1),33-37.
MLA Qu, Yanchun,et al."The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese".DIABETES RESEARCH AND CLINICAL PRACTICE 81.1(2008):33-37.
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