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The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease
Wang, Binbin; Jin, Feng; Yang, Ze; Lu, Zeping; Kan, Rui; Li, Shu; Zheng, Chenguang; Wang, Li; L. Wang
2006
Source PublicationJOURNAL OF MOLECULAR NEUROSCIENCE
ISSN0895-8696
SubtypeArticle
Volume30Issue:3Pages:267-271
AbstractSeveral studies have shown that a common insertion (I)/deletion (D) polymorphism of angiotensin-converting enzyme (ACE) gene may confer an increased risk of late-onset Alzheimer disease (LOAD). However, the result has not been replicated by all studies. In order to clarify the role of the polymorphism for the occurrence of LOAD in Chinese and the possibility of a synergistic effect with the apolipoprotein E allele 4 on the risk of Alzheimer disease, we examined the ACE and APOE genotypes in a Chinese sample consisting of 104 sporadic LOAD patients and 128 healthy controls. An obvious difference of allelic and genotypic distributions of ACE I/D polymorphism between cases and controls was observed (chi2 = 6.61, df = 2, p = 0.037 by genotype; chi2 = 4.67, df = 1, p = 0.031 by allele). And ACE I allele carriers showed an increased risk for LOAD developing (chi2 = 6.59, df = 1, p =0.01, OR = 2.91, 95% CI 1.25-6.77). After stratifying by APOE epsilon 4 status, the increased LOAD risks associated with I allele carriers only in the APOE epsilon 4 noncarriers was seen (chi2 = 4.12, df = 1, p = 0.042). Logistic regression analysis of total subjects demonstrated a more than sevenfold increase in the risk of developing LOAD in subjects carrying both the ACE I allele and the APOE epsilon 4 (OR = 7.39, 95% CI 2.50-21.89, p < 0.001). Our data revealed that ACE I/D polymorphism is considered to be an additional risk factor, which has strong synergistic interaction with APOE epsilon 4 on the risk of LOAD.; Several studies have shown that a common insertion (I)/deletion (D) polymorphism of angiotensin-converting enzyme (ACE) gene may confer an increased risk of late-onset Alzheimer disease (LOAD). However, the result has not been replicated by all studies. In order to clarify the role of the polymorphism. for the occurrence of LOAD in Chinese and the possibility of a synergistic effect with the apolipoprotein E allele 4 on the risk of Alzheimer disease, we examined the ACE and APOE genotypes in a Chinese sample consisting of 104 sporadic LOAD patients and 128 healthy controls. An obvious difference of allelic and genotypic distributions of ACE I/D polymorphism between cases and controls was observed (chi(2) = 6.61, df = 2, p = 0.037 by genotype; chi(2) = 4.67, df = 1, p = 0.031 by allele). And ACE I allele carriers showed an increased risk for LOAD developing (chi(2) = 6.59, df = 1, p = 0.01, OR = 2.91,95% CI 1.25-6.77). After stratifying by APOE epsilon 4 status, the increased LOAD risks associated with I allele carriers only in the APOE epsilon 4 noncarriers was seen (chi(2) = 4.12, df = 1, p = 0.042). Logistic regression analysis of total subjects demonstrated a more than sevenfold increase in the risk of developing LOAD in subjects carrying both the ACE I allele and the APOE epsilon 4 (OR = 7.39,95% CI 2.50-21.89, p < 0.001). Our data revealed that ACE I/D polymorphism is considered to be an additional risk factor, which has strong synergistic interaction with APOE epsilon 4 on the risk of LOAD.
Keywordlate-onset Alzheimer's disease angiotensin-converting enzyme ACE apolipoprotein E polymorphism Chinese
Subject Area神经病学
Indexed BySCI
Language英语
WOS IDWOS:000243782200002
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5773
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorL. Wang
Affiliation1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Human & Anim Genet, Beijing, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Res Lab Behav Biol, Beijing, Peoples R China
4.Beijing Hosp, Minist Hlth, Inst Geriatr, Med Genet Lab, Beijing, Peoples R China
5.Jiangbin Hosp, Nanning, Guangxi, Peoples R China
Recommended Citation
GB/T 7714
Wang, Binbin,Jin, Feng,Yang, Ze,et al. The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2006,30(3):267-271.
APA Wang, Binbin.,Jin, Feng.,Yang, Ze.,Lu, Zeping.,Kan, Rui.,...&L. Wang.(2006).The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease.JOURNAL OF MOLECULAR NEUROSCIENCE,30(3),267-271.
MLA Wang, Binbin,et al."The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease".JOURNAL OF MOLECULAR NEUROSCIENCE 30.3(2006):267-271.
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