The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease

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	The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease
	Wang, Binbin; Jin, Feng; Yang, Ze ; Lu, Zeping ; Kan, Rui ; Li, Shu; Zheng, Chenguang ; Wang, Li; L. Wang
摘要	Several studies have shown that a common insertion (I)/deletion (D) polymorphism of angiotensin-converting enzyme (ACE) gene may confer an increased risk of late-onset Alzheimer disease (LOAD). However, the result has not been replicated by all studies. In order to clarify the role of the polymorphism for the occurrence of LOAD in Chinese and the possibility of a synergistic effect with the apolipoprotein E allele 4 on the risk of Alzheimer disease, we examined the ACE and APOE genotypes in a Chinese sample consisting of 104 sporadic LOAD patients and 128 healthy controls. An obvious difference of allelic and genotypic distributions of ACE I/D polymorphism between cases and controls was observed (chi2 = 6.61, df = 2, p = 0.037 by genotype; chi2 = 4.67, df = 1, p = 0.031 by allele). And ACE I allele carriers showed an increased risk for LOAD developing (chi2 = 6.59, df = 1, p =0.01, OR = 2.91, 95% CI 1.25-6.77). After stratifying by APOE epsilon 4 status, the increased LOAD risks associated with I allele carriers only in the APOE epsilon 4 noncarriers was seen (chi2 = 4.12, df = 1, p = 0.042). Logistic regression analysis of total subjects demonstrated a more than sevenfold increase in the risk of developing LOAD in subjects carrying both the ACE I allele and the APOE epsilon 4 (OR = 7.39, 95% CI 2.50-21.89, p < 0.001). Our data revealed that ACE I/D polymorphism is considered to be an additional risk factor, which has strong synergistic interaction with APOE epsilon 4 on the risk of LOAD.; Several studies have shown that a common insertion (I)/deletion (D) polymorphism of angiotensin-converting enzyme (ACE) gene may confer an increased risk of late-onset Alzheimer disease (LOAD). However, the result has not been replicated by all studies. In order to clarify the role of the polymorphism. for the occurrence of LOAD in Chinese and the possibility of a synergistic effect with the apolipoprotein E allele 4 on the risk of Alzheimer disease, we examined the ACE and APOE genotypes in a Chinese sample consisting of 104 sporadic LOAD patients and 128 healthy controls. An obvious difference of allelic and genotypic distributions of ACE I/D polymorphism between cases and controls was observed (chi(2) = 6.61, df = 2, p = 0.037 by genotype; chi(2) = 4.67, df = 1, p = 0.031 by allele). And ACE I allele carriers showed an increased risk for LOAD developing (chi(2) = 6.59, df = 1, p = 0.01, OR = 2.91,95% CI 1.25-6.77). After stratifying by APOE epsilon 4 status, the increased LOAD risks associated with I allele carriers only in the APOE epsilon 4 noncarriers was seen (chi(2) = 4.12, df = 1, p = 0.042). Logistic regression analysis of total subjects demonstrated a more than sevenfold increase in the risk of developing LOAD in subjects carrying both the ACE I allele and the APOE epsilon 4 (OR = 7.39,95% CI 2.50-21.89, p < 0.001). Our data revealed that ACE I/D polymorphism is considered to be an additional risk factor, which has strong synergistic interaction with APOE epsilon 4 on the risk of LOAD.
关键词	late-onset Alzheimer's disease angiotensin-converting enzyme ACE apolipoprotein E polymorphism Chinese
学科领域	神经病学
	2006
语种	英语
发表期刊	JOURNAL OF MOLECULAR NEUROSCIENCE
ISSN	0895-8696
卷号	30 期号:3 页码:267-271
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000243782200002
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/5773
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	L. Wang
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Human & Anim Genet, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Res Lab Behav Biol, Beijing, Peoples R China 4.Beijing Hosp, Minist Hlth, Inst Geriatr, Med Genet Lab, Beijing, Peoples R China 5.Jiangbin Hosp, Nanning, Guangxi, Peoples R China
推荐引用方式 GB/T 7714	Wang, Binbin,Jin, Feng,Yang, Ze,et al. The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2006,30(3):267-271.
APA	Wang, Binbin.,Jin, Feng.,Yang, Ze.,Lu, Zeping.,Kan, Rui.,...&L. Wang.(2006).The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease.JOURNAL OF MOLECULAR NEUROSCIENCE,30(3),267-271.
MLA	Wang, Binbin,et al."The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease".JOURNAL OF MOLECULAR NEUROSCIENCE 30.3(2006):267-271.

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