The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease
Wang, Binbin; Jin, Feng; Yang, Ze; Lu, Zeping; Kan, Rui; Li, Shu; Zheng, Chenguang; Wang, Li; L. Wang
2006
发表期刊JOURNAL OF MOLECULAR NEUROSCIENCE
ISSN0895-8696
文章类型Article
卷号30期号:3页码:267-271
摘要Several studies have shown that a common insertion (I)/deletion (D) polymorphism of angiotensin-converting enzyme (ACE) gene may confer an increased risk of late-onset Alzheimer disease (LOAD). However, the result has not been replicated by all studies. In order to clarify the role of the polymorphism for the occurrence of LOAD in Chinese and the possibility of a synergistic effect with the apolipoprotein E allele 4 on the risk of Alzheimer disease, we examined the ACE and APOE genotypes in a Chinese sample consisting of 104 sporadic LOAD patients and 128 healthy controls. An obvious difference of allelic and genotypic distributions of ACE I/D polymorphism between cases and controls was observed (chi2 = 6.61, df = 2, p = 0.037 by genotype; chi2 = 4.67, df = 1, p = 0.031 by allele). And ACE I allele carriers showed an increased risk for LOAD developing (chi2 = 6.59, df = 1, p =0.01, OR = 2.91, 95% CI 1.25-6.77). After stratifying by APOE epsilon 4 status, the increased LOAD risks associated with I allele carriers only in the APOE epsilon 4 noncarriers was seen (chi2 = 4.12, df = 1, p = 0.042). Logistic regression analysis of total subjects demonstrated a more than sevenfold increase in the risk of developing LOAD in subjects carrying both the ACE I allele and the APOE epsilon 4 (OR = 7.39, 95% CI 2.50-21.89, p < 0.001). Our data revealed that ACE I/D polymorphism is considered to be an additional risk factor, which has strong synergistic interaction with APOE epsilon 4 on the risk of LOAD.; Several studies have shown that a common insertion (I)/deletion (D) polymorphism of angiotensin-converting enzyme (ACE) gene may confer an increased risk of late-onset Alzheimer disease (LOAD). However, the result has not been replicated by all studies. In order to clarify the role of the polymorphism. for the occurrence of LOAD in Chinese and the possibility of a synergistic effect with the apolipoprotein E allele 4 on the risk of Alzheimer disease, we examined the ACE and APOE genotypes in a Chinese sample consisting of 104 sporadic LOAD patients and 128 healthy controls. An obvious difference of allelic and genotypic distributions of ACE I/D polymorphism between cases and controls was observed (chi(2) = 6.61, df = 2, p = 0.037 by genotype; chi(2) = 4.67, df = 1, p = 0.031 by allele). And ACE I allele carriers showed an increased risk for LOAD developing (chi(2) = 6.59, df = 1, p = 0.01, OR = 2.91,95% CI 1.25-6.77). After stratifying by APOE epsilon 4 status, the increased LOAD risks associated with I allele carriers only in the APOE epsilon 4 noncarriers was seen (chi(2) = 4.12, df = 1, p = 0.042). Logistic regression analysis of total subjects demonstrated a more than sevenfold increase in the risk of developing LOAD in subjects carrying both the ACE I allele and the APOE epsilon 4 (OR = 7.39,95% CI 2.50-21.89, p < 0.001). Our data revealed that ACE I/D polymorphism is considered to be an additional risk factor, which has strong synergistic interaction with APOE epsilon 4 on the risk of LOAD.
关键词late-onset Alzheimer's disease angiotensin-converting enzyme ACE apolipoprotein E polymorphism Chinese
学科领域神经病学
收录类别SCI
语种英语
WOS记录号WOS:000243782200002
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5773
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者L. Wang
作者单位1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Human & Anim Genet, Beijing, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Res Lab Behav Biol, Beijing, Peoples R China
4.Beijing Hosp, Minist Hlth, Inst Geriatr, Med Genet Lab, Beijing, Peoples R China
5.Jiangbin Hosp, Nanning, Guangxi, Peoples R China
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Wang, Binbin,Jin, Feng,Yang, Ze,et al. The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2006,30(3):267-271.
APA Wang, Binbin.,Jin, Feng.,Yang, Ze.,Lu, Zeping.,Kan, Rui.,...&L. Wang.(2006).The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease.JOURNAL OF MOLECULAR NEUROSCIENCE,30(3),267-271.
MLA Wang, Binbin,et al."The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease".JOURNAL OF MOLECULAR NEUROSCIENCE 30.3(2006):267-271.
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