Thirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cues
Xiao, ZW; Lee, T; Zhang, JX; Wu, QL; Wu, RH; Weng, XC; Hu, XP; Z. W. Xiao
2006-06-28
发表期刊DRUG AND ALCOHOL DEPENDENCE
ISSN0376-8716
文章类型Article
卷号83期号:2页码:157-162
摘要Relapse to drug use is frequently preceded or caused by craving, an intense desire for drug. Advances in functional brain imaging techniques make it possible to directly investigate this special mental state in vivo and non-invasively. Extant imaging studies on craving have been mostly on cocaine which is the dominant drug abused in the U.S. Employing functional MRI, we examined substance specificity of the neural circuitry underlying craving for heroin. Heroin is the primary drug abused in south-east Asia and has, particularly, become a serious social problem for China in recent years. Following abstinence from water and drug, 14 active heroin addicts (all male, mean age 33.2 years, average drug use history 7.1 years) underwent scanning inside a 1.5T Philips MR scanner during exposure to water-related, drug-related, and neutral cues. Water-related cues elicited anterior cingulate activation (Brodmann's area BA 32/24). Drug-related cues activated bilateral inferior frontal cortex (BA 44/45), confirming the critical role of prefrontal cortex in drug craving. Results suggest heroin craving may involve different neural substrates than do desire from basic physiological drives, such as thirst. As the first fMRI study of heroin craving, our study adds to the scant but much-needed brain imaging literature on heroin addiction.; Relapse to drug use is frequently preceded or caused by craving, an intense desire for drug. Advances in functional brain imaging techniques make it possible to directly investigate this special mental state in vivo and non-invasively. Extant imaging studies on craving have been mostly on cocaine which is the dominant drug abused in the U.S. Employing functional MRI, we examined substance specificity of the neural circuitry underlying craving for heroin. Heroin is the primary drug abused in south-east Asia and has, particularly, become a serious social problem for China in recent years. Following abstinence from water and drug, 14 active heroin addicts (all male, mean age 33.2 years, average drug use history 7.1 years) underwent scanning inside a 1.5T Philips MR scanner during exposure to water-related, drug-related, and neutral cues. Water-related cues elicited anterior cingulate activation (Brodmann's area BA 32/24). Drug-related cues activated bilateral inferior frontal cortex (BA 44/45), confirming the critical role of prefromal cortex in drug craving. Results suggest heroin craving may involve different neural substrates than do desire from basic physiological drives, such as thirst. As the first fMRI study of heroin craving, our study adds to the scant but much-needed brain imaging literature on heroin addiction. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
关键词addiction craving drug-dependence heroin opiate functional MRI
学科领域医学心理学
收录类别SCI
语种英语
WOS记录号WOS:000238702100008
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5817
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Z. W. Xiao
作者单位1.Shantou Univ, Guangdong Key Lab Med Mol Imaging, Affiliated Hosp 1, Sch Med, Shantou, Peoples R China
2.Univ Hong Kong, Neuropsychol Lab, Hong Kong, Hong Kong, Peoples R China
3.MacLehose Med Rehabil Ctr, Inst Clin Neuropsychol, Hong Kong, Hong Kong, Peoples R China
4.Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China
5.Chinese Acad Sci, Lab Higher Brain Funct, Inst Psychol, Beijing, Peoples R China
6.Georgia Inst Technol, Coulter Dept Biomed Engn, Atlanta, GA 30332 USA
7.Emory Univ, Atlanta, GA 30322 USA
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Xiao, ZW,Lee, T,Zhang, JX,et al. Thirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cues[J]. DRUG AND ALCOHOL DEPENDENCE,2006,83(2):157-162.
APA Xiao, ZW.,Lee, T.,Zhang, JX.,Wu, QL.,Wu, RH.,...&Z. W. Xiao.(2006).Thirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cues.DRUG AND ALCOHOL DEPENDENCE,83(2),157-162.
MLA Xiao, ZW,et al."Thirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cues".DRUG AND ALCOHOL DEPENDENCE 83.2(2006):157-162.
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