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Corticosterone reinforces motivation for drug-seeking in morphine-dependent rats in Morris maze performance
N. Sul; J. Chen; J. Hu; C. Sandi; J. J. Yang; X. Y. Yang
2000
Conference Name会议论文
Pages132-132
Conference Date2000
Conference PlaceStockholm
AbstractCorticosterone and morphine's effect on motivational intensity for drug-seeking was investigated. Rats were given intraperitoneal injections with morphine, corticosterone, morphine plus corticosterone immediately after trained without platform. Then in the maze with platform, only the rats avoiding the platform for 1min were given the drugs. Results indicated that corticosterone plus morphine significantly increased the latency of locating the platform over 4,8,16 day withdrawal periods, while with morphine alone the effect occurred only on the 4th day. Possible mechanisms of the facilitating effects of corticosterone depend on increasing sensitivity to morphine or enhancing retention of the propensity of drug intake.
Funding OrganizationIUPsyS
Subject Area医学心理学
Indexed BySSCI
Language英语
WOS IDWOS:000088388801280
Citation statistics
Document Type会议论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5897
Collection中国科学院心理研究所回溯数据库(1956-2010)
Recommended Citation
GB/T 7714
N. Sul,J. Chen,J. Hu,et al. Corticosterone reinforces motivation for drug-seeking in morphine-dependent rats in Morris maze performance[C],2000:132-132.
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