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Modulation of medial prefrontal cortical dopamine on the expression of morphine-induced sensitization in rats
X. J. Luo; X. G. Zheng; Y. H. Li; J. Liu; B. P. Tan
2004
Conference Name会议论文
Pages285-285
Conference Date2004
Conference PlaceBeijing
AbstractRats were administered morphine (5mg•kg-1, i.p.) or saline for seven days and tested with intra-mPFC (medial prefrontal cortex) microinjection of D1 receptor agonist SKF38393 (0-2.0 μg/side), or D1 receptor antagonist SCH23390 (0-1.0 μg/side). SKF38393 dose-dependently suppressed the expression of morphine sensitization while SCH23390 enhanced the locomotor response to morphine. But for saline-pretreated rats, the same doses of SKF38393 and SCH23390 had little influence on their locomotor activity. These results indicate that morphine-induced hypersensitization of mPFC dopamine may be a neural substrate mediating morphine sensitization, and further suggest the inhibitive effects of mPFC dopamine on the expression of morphine sensitization.
Funding OrganizationIUPsyS
Subject Area医学心理学
Indexed BySSCI
Language英语
WOS IDWOS:000226118002598
Citation statistics
Document Type会议论文
Identifierhttp://ir.psych.ac.cn/handle/311026/6341
Collection中国科学院心理研究所回溯数据库(1956-2010)
Recommended Citation
GB/T 7714
X. J. Luo,X. G. Zheng,Y. H. Li,et al. Modulation of medial prefrontal cortical dopamine on the expression of morphine-induced sensitization in rats[C],2004:285-285.
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