Modulation of medial prefrontal cortical dopamine on the expression of morphine-induced sensitization in rats

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	Modulation of medial prefrontal cortical dopamine on the expression of morphine-induced sensitization in rats
	X. J. Luo; X. G. Zheng; Y. H. Li; J. Liu; B. P. Tan
	2004
会议名称	会议论文
页码	285-285
会议日期	2004
会议地点	Beijing
摘要	Rats were administered morphine (5mg•kg-1, i.p.) or saline for seven days and tested with intra-mPFC (medial prefrontal cortex) microinjection of D1 receptor agonist SKF38393 (0-2.0 μg/side), or D1 receptor antagonist SCH23390 (0-1.0 μg/side). SKF38393 dose-dependently suppressed the expression of morphine sensitization while SCH23390 enhanced the locomotor response to morphine. But for saline-pretreated rats, the same doses of SKF38393 and SCH23390 had little influence on their locomotor activity. These results indicate that morphine-induced hypersensitization of mPFC dopamine may be a neural substrate mediating morphine sensitization, and further suggest the inhibitive effects of mPFC dopamine on the expression of morphine sensitization.
会议主办者	IUPsyS
学科领域	医学心理学
收录类别	SSCI
语种	英语
WOS记录号	WOS:000226118002598
引用统计
文献类型	会议论文
条目标识符	http://ir.psych.ac.cn/handle/311026/6341
专题	中国科学院心理研究所回溯数据库(1956-2010)
推荐引用方式 GB/T 7714	X. J. Luo,X. G. Zheng,Y. H. Li,et al. Modulation of medial prefrontal cortical dopamine on the expression of morphine-induced sensitization in rats[C],2004:285-285.