PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
谢希; 邵枫; 罗晓敏; 管西婷; 孟庆轩; 王玮文
Source Publication中国神经精神疾病杂志
Other AbstractObjective To establish chronic stress model of depression in adolescent rats and to examine the effects of different antidepressant treatment on depression and anxiety-related behaviors. Methods Male Wistar rats were given 21-day chronic mild stress (CMS) during their adolescence (postnatal day 3050, PND3050). During stress period, rats were treated with fluoxetine (10 mg/kg i.p.) or imipramine (10 mg/kg i.p.), respectively. After stress, rats were tested for behavioral observation using body weight gain, saccharine test, open field and elevated plus-maze (EPM). Results Compared with control/vehicle (n=10) group, stress/vehicle (n=11) group displayed lower weight gain, saccharine preference index and the number of rearing in open field (P<0.05). Antidepressant fluoxetine, but not imipramine reversed anhedonia and the decrease of the number of rearing induced by stress. In addition, compared with early adolescent(PND29) rats, late adolescent (PND52) rats in control/vehicle group exhibited less open arm entries and open arm time, more closed arm time in EPM (P<0.05). Rats in stress/vehicle group showed more open arm entries and less closed arm time than controls(P<0.05). Both fluoxetine and imipramine had no effects on such changes. Conclusions Stress can induce the depression-like behavior in adolescent rats. Fluoxetine, but not imipramine,can effectively reverse anhedonia induced by stress. However, Both antidepressants have no significant effects on stress-induced decrease in developmental increment of anxious behavior during adolescence. These data suggest that chronic mild stress have complicated effects on depressive and anxious behavior in adolescent rats.
Keyword抑郁 应激 青幼期 丙米嗪 氟西汀
Subject Area生理心理学
Indexed ByCSCD
Funding Project一室林文娟课题组
Citation statistics
Document Type期刊论文
Corresponding Author王玮文
Recommended Citation
GB/T 7714
谢希,邵枫,罗晓敏,等. 氟西汀和丙米嗪对应激诱导的青幼期大鼠抑郁和焦虑样行为的不同影响[J]. 中国神经精神疾病杂志,2010,36(1):14-18.
APA 谢希,邵枫,罗晓敏,管西婷,孟庆轩,&王玮文.(2010).氟西汀和丙米嗪对应激诱导的青幼期大鼠抑郁和焦虑样行为的不同影响.中国神经精神疾病杂志,36(1),14-18.
MLA 谢希,et al."氟西汀和丙米嗪对应激诱导的青幼期大鼠抑郁和焦虑样行为的不同影响".中国神经精神疾病杂志 36.1(2010):14-18.
Files in This Item: Download All
File Name/Size DocType Version Access License
20101129051009氟西汀和丙米(359KB) 开放获取--View Download
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[谢希]'s Articles
[邵枫]'s Articles
[罗晓敏]'s Articles
Baidu academic
Similar articles in Baidu academic
[谢希]'s Articles
[邵枫]'s Articles
[罗晓敏]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[谢希]'s Articles
[邵枫]'s Articles
[罗晓敏]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 20101129051009氟西汀和丙米嗪对应激诱导的青幼期大鼠抑郁和焦虑样行为的不同影响.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.