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Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine
Li, Nanxin1,2; He, Xiaolu1; Zhang, Yu1; Qi, Xiaoli3; Li, Huijie3; Zhu, Xinhong4; He, Shuchang1; Li, NX (reprint author), Peking Univ, Dept Psychol, Beijing 100871, Peoples R China.
2011-09-01
发表期刊INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
ISSN1461-1457
文章类型Article
卷号14期号:8页码:1091-1098
产权排序3
摘要The anticonvulsant drug lamotrigine has been shown to produce antidepressant effects in patients with bipolar disorder. To date, only a few preclinical studies have been conducted using lamotrigine treatment in the forced swim test (FST), an animal model of depression with low face validity. The underlying mechanisms by which lamotrigine works have not been well characterized either. This study extends earlier work on the role of brain-derived neurotrophic factor (BDNF) in regulating the antidepressant actions of lamotrigine. We showed that in rats subjected to chronic unpredictable stress, chronic administration of 30 mg/kg lamotrigine ameliorates behavioural deficits of stressed rats in both sucrose preference test (SPT) and novelty-suppressed feeding test (NSFT). In parallel, chronic lamotrigine treatment up-regulates frontal and hippocampal BDNF protein expression in both naive and stressed animals, and restores the stress-induced down-regulation of BDNF levels. In addition, inhibition of BDNF signalling by infusion of K252a, an inhibitor of the BDNF receptor TrkB, blocks the antidepressant effects of lamotrigine in SPT, NSFT and FST. Taken together, this study provides further evidence that BDNF is an essential mediator for the antidepressant effects of lamotrigine.
关键词Antidepressant BDNF CUS FST lamotrigine NSFT
学科领域Medical Psychology
收录类别SCI
语种英语
项目资助者American Psychological Association ; Natural Science Foundation of China [30870768]
资助项目一室李娟课题组
项目简介This project was funded by American Psychological Association (Scott Mesh Honorary Scholarship) to N. L. and Natural Science Foundation of China (Grant no. 30870768) to S. H.
WOS记录号WOS:000294564500007
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被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/6907
专题健康与遗传心理学研究室
通讯作者Li, NX (reprint author), Peking Univ, Dept Psychol, Beijing 100871, Peoples R China.
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06520 USA
3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
4.So Med Univ, Dept Anat & Neurobiol, Guangzhou, Guangdong, Peoples R China
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Li, Nanxin,He, Xiaolu,Zhang, Yu,et al. Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2011,14(8):1091-1098.
APA Li, Nanxin.,He, Xiaolu.,Zhang, Yu.,Qi, Xiaoli.,Li, Huijie.,...&Li, NX .(2011).Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,14(8),1091-1098.
MLA Li, Nanxin,et al."Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 14.8(2011):1091-1098.
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