| Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine | |
Li, Nanxin1,2; He, Xiaolu1; Zhang, Yu1; Qi, Xiaoli3 ; Li, Huijie3; Zhu, Xinhong4; He, Shuchang1; Li, NX (reprint author), Peking Univ, Dept Psychol, Beijing 100871, Peoples R China.
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| 心理所单位排序 | 3 |
| 摘要 | The anticonvulsant drug lamotrigine has been shown to produce antidepressant effects in patients with bipolar disorder. To date, only a few preclinical studies have been conducted using lamotrigine treatment in the forced swim test (FST), an animal model of depression with low face validity. The underlying mechanisms by which lamotrigine works have not been well characterized either. This study extends earlier work on the role of brain-derived neurotrophic factor (BDNF) in regulating the antidepressant actions of lamotrigine. We showed that in rats subjected to chronic unpredictable stress, chronic administration of 30 mg/kg lamotrigine ameliorates behavioural deficits of stressed rats in both sucrose preference test (SPT) and novelty-suppressed feeding test (NSFT). In parallel, chronic lamotrigine treatment up-regulates frontal and hippocampal BDNF protein expression in both naive and stressed animals, and restores the stress-induced down-regulation of BDNF levels. In addition, inhibition of BDNF signalling by infusion of K252a, an inhibitor of the BDNF receptor TrkB, blocks the antidepressant effects of lamotrigine in SPT, NSFT and FST. Taken together, this study provides further evidence that BDNF is an essential mediator for the antidepressant effects of lamotrigine. |
| 关键词 | Antidepressant BDNF CUS FST lamotrigine NSFT |
| 学科领域 | Medical Psychology |
| 2011-09-01 | |
| 语种 | 英语 |
| 发表期刊 | INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
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| ISSN | 1461-1457 |
| 卷号 | 14期号:8页码:1091-1098 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| 资助项目 | 一室李娟课题组 |
| 项目简介 | This project was funded by American Psychological Association (Scott Mesh Honorary Scholarship) to N. L. and Natural Science Foundation of China (Grant no. 30870768) to S. H. |
| WOS记录号 | WOS:000294564500007 |
| 资助机构 | American Psychological Association ; Natural Science Foundation of China [30870768] |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://ir.psych.ac.cn/handle/311026/6907 |
| 专题 | 健康与遗传心理学研究室 |
| 通讯作者 | Li, NX (reprint author), Peking Univ, Dept Psychol, Beijing 100871, Peoples R China. |
| 作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06520 USA 3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 4.So Med Univ, Dept Anat & Neurobiol, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Nanxin,He, Xiaolu,Zhang, Yu,et al. Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2011,14(8):1091-1098. |
| APA | Li, Nanxin.,He, Xiaolu.,Zhang, Yu.,Qi, Xiaoli.,Li, Huijie.,...&Li, NX .(2011).Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,14(8),1091-1098. |
| MLA | Li, Nanxin,et al."Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 14.8(2011):1091-1098. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS000294564500007.p（142KB） | 开放获取 | Apache License | 浏览 下载 | |||
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