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Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine
Li, Nanxin1,2; He, Xiaolu1; Zhang, Yu1; Qi, Xiaoli3; Li, Huijie3; Zhu, Xinhong4; He, Shuchang1; Li, NX (reprint author), Peking Univ, Dept Psychol, Beijing 100871, Peoples R China.
2011-09-01
Source PublicationINTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
ISSN1461-1457
SubtypeArticle
Volume14Issue:8Pages:1091-1098
Contribution Rank3
AbstractThe anticonvulsant drug lamotrigine has been shown to produce antidepressant effects in patients with bipolar disorder. To date, only a few preclinical studies have been conducted using lamotrigine treatment in the forced swim test (FST), an animal model of depression with low face validity. The underlying mechanisms by which lamotrigine works have not been well characterized either. This study extends earlier work on the role of brain-derived neurotrophic factor (BDNF) in regulating the antidepressant actions of lamotrigine. We showed that in rats subjected to chronic unpredictable stress, chronic administration of 30 mg/kg lamotrigine ameliorates behavioural deficits of stressed rats in both sucrose preference test (SPT) and novelty-suppressed feeding test (NSFT). In parallel, chronic lamotrigine treatment up-regulates frontal and hippocampal BDNF protein expression in both naive and stressed animals, and restores the stress-induced down-regulation of BDNF levels. In addition, inhibition of BDNF signalling by infusion of K252a, an inhibitor of the BDNF receptor TrkB, blocks the antidepressant effects of lamotrigine in SPT, NSFT and FST. Taken together, this study provides further evidence that BDNF is an essential mediator for the antidepressant effects of lamotrigine.
KeywordAntidepressant BDNF CUS FST lamotrigine NSFT
Subject AreaMedical Psychology
Indexed BySCI
Language英语
Funding OrganizationAmerican Psychological Association ; Natural Science Foundation of China [30870768]
Funding Project一室李娟课题组
Project Intro.This project was funded by American Psychological Association (Scott Mesh Honorary Scholarship) to N. L. and Natural Science Foundation of China (Grant no. 30870768) to S. H.
WOS IDWOS:000294564500007
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/6907
Collection健康与遗传心理学研究室
Corresponding AuthorLi, NX (reprint author), Peking Univ, Dept Psychol, Beijing 100871, Peoples R China.
Affiliation1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06520 USA
3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
4.So Med Univ, Dept Anat & Neurobiol, Guangzhou, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Li, Nanxin,He, Xiaolu,Zhang, Yu,et al. Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2011,14(8):1091-1098.
APA Li, Nanxin.,He, Xiaolu.,Zhang, Yu.,Qi, Xiaoli.,Li, Huijie.,...&Li, NX .(2011).Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,14(8),1091-1098.
MLA Li, Nanxin,et al."Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 14.8(2011):1091-1098.
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