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Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain
Meng, Qingxuan1; Li, Nanxin1,2; Han, Xiao1; Shao, Feng1; Wang, Weiwen3; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
2011-01-10
Source PublicationEUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
SubtypeArticle
Volume650Issue:1Pages:229-232
Contribution Rank3
AbstractAdolescence is a critical period for the development of neural plasticity Social isolation is an important animal model for various neurodevelopmental disorders Brain derived neurotrophic factor (BDNF) mediates many important brain functions such as neural plasticity and aberrations in its expression have been implicated in many brain disorders However to date there have been few reports of effects of adolescent social isolation on BDNF expression in adult animals In the present study we subjected weaning Sprague Dawley rats to a four-week early adolescence social isolation procedure followed by lour-week standarad housing until adulthood for molecular assays BDNF protein levels in several key forebrain regions relevant to brain development were investigated using immunohistochemistry including frontal and cingulate cortex as well as hippocampus Our results show that adolescent social isolation significantly increased BDNF protein expression in the medial prefrontal cortex and all three sub fields of the hippocampus including CA I CA2/3 and dentate gyms This study advances the use of adolescent social isolation as an animal model for studying neurobiological underpinnings of various neurodevelopmental disorders (C) 2010 Elsevier B V All rights reserved
KeywordAdolescent BDNF Frontal cortex Hippocampus Social isolation
Subject AreaPhysiological Psychology/biological Psychology
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Indexed BySCI
Language英语
Funding Project一室林文娟课题组
WOS IDWOS:000285893800031
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/6909
Collection健康与遗传心理学研究室
Corresponding AuthorShao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
Affiliation1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06508 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Meng, Qingxuan,Li, Nanxin,Han, Xiao,et al. Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2011,650(1):229-232.
APA Meng, Qingxuan,Li, Nanxin,Han, Xiao,Shao, Feng,Wang, Weiwen,&Shao, F .(2011).Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain.EUROPEAN JOURNAL OF PHARMACOLOGY,650(1),229-232.
MLA Meng, Qingxuan,et al."Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain".EUROPEAN JOURNAL OF PHARMACOLOGY 650.1(2011):229-232.
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