Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain | |
Meng, Qingxuan1; Li, Nanxin1,2; Han, Xiao1; Shao, Feng1; Wang, Weiwen3; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China. | |
心理所单位排序 | 3 |
摘要 | Adolescence is a critical period for the development of neural plasticity Social isolation is an important animal model for various neurodevelopmental disorders Brain derived neurotrophic factor (BDNF) mediates many important brain functions such as neural plasticity and aberrations in its expression have been implicated in many brain disorders However to date there have been few reports of effects of adolescent social isolation on BDNF expression in adult animals In the present study we subjected weaning Sprague Dawley rats to a four-week early adolescence social isolation procedure followed by lour-week standarad housing until adulthood for molecular assays BDNF protein levels in several key forebrain regions relevant to brain development were investigated using immunohistochemistry including frontal and cingulate cortex as well as hippocampus Our results show that adolescent social isolation significantly increased BDNF protein expression in the medial prefrontal cortex and all three sub fields of the hippocampus including CA I CA2/3 and dentate gyms This study advances the use of adolescent social isolation as an animal model for studying neurobiological underpinnings of various neurodevelopmental disorders (C) 2010 Elsevier B V All rights reserved |
关键词 | Adolescent BDNF Frontal cortex Hippocampus Social isolation |
学科领域 | Physiological Psychology/biological Psychology |
2011-01-10 | |
语种 | 英语 |
发表期刊 | EUROPEAN JOURNAL OF PHARMACOLOGY |
ISSN | 0014-2999 |
卷号 | 650期号:1页码:229-232 |
期刊论文类型 | Article |
URL | 查看原文 |
收录类别 | SCI |
资助项目 | 一室林文娟课题组 |
WOS记录号 | WOS:000285893800031 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/6909 |
专题 | 健康与遗传心理学研究室 |
通讯作者 | Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China. |
作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06508 USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Meng, Qingxuan,Li, Nanxin,Han, Xiao,et al. Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2011,650(1):229-232. |
APA | Meng, Qingxuan,Li, Nanxin,Han, Xiao,Shao, Feng,Wang, Weiwen,&Shao, F .(2011).Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain.EUROPEAN JOURNAL OF PHARMACOLOGY,650(1),229-232. |
MLA | Meng, Qingxuan,et al."Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain".EUROPEAN JOURNAL OF PHARMACOLOGY 650.1(2011):229-232. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
WOS000285893800031.p(387KB) | 限制开放 | Apache License | 请求全文 |
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