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Gene expression of conditioned locomotion and context-specific locomotor sensitization controlled by morphine-associated environment
Liang, Jing1; Chen, Ji-Huan2; Chen, Xiao-Hong3; Peng, Yong-Hua1; Zheng, Xi-Geng1; Zheng, XG (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2011
发表期刊BEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
文章类型Article
卷号216期号:1页码:321-331
产权排序1
摘要The nucleus accumbens (NAc) is involved in contextual drug associations, which might be particularly important for environmental cue-induced relapse to drug seeking. In the present study, rats were first administered repeated morphine for 5 days (5 mg/kg, i.p.) in a contextually paired and unpaired design. After reexposure to the morphine-associated environment, which induced conditioned locomotor activity in the morphine-paired group, we performed a rat 27k 70-mer oligo array to profile gene expression in the NAc. One hundred fifty-five upregulated and 88 downregulated genes were found in the paired group compared with the unpaired group. Eight gene transcripts were then selected to confirm their alterations by quantitative real-time polymerase chain reaction (qRT-PCR). The identified genes generally play important roles in neuroactive receptor-ligand interactions, synapse plasticity, ion transport, and protein phosphorylation. Furthermore, the expression of the eight selected genes that were identified and confirmed to show significant fold changes in the first microarray experiment were again measured with qRT-PCR after morphine challenge (2 mg/kg, i.p.). As expected, 2 mg/kg morphine-induced context-specific sensitization. Meanwhile, mRNA expression of the selected genes showed marked upregulation in the morphine-paired group compared with the unpaired and acute groups. These results suggest that alterations in the expression of the identified genes in the NAc may contribute to the neuroplasticity underlying contextual cue-induced relapse to drug use. (C) 2010 Elsevier B.V. All rights reserved.
关键词Morphine Conditioned response Sensitization Nucleus accumbens Microarray
学科领域Cognitive Neuroscience
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收录类别SCI
语种英语
项目资助者National Foundation of Natural Science [30470578, 30900400, 30770722] ; Institute of Psychology, Chinese Academy of Sciences [08CX053005]
资助项目一室郑希耕课题组
项目简介This work was supported by the National Foundation of Natural Science (30470578, 30900400 and 30770722) and the Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (08CX053005). We would like to thank Michael Arends for editing the manuscript.
WOS记录号WOS:000285318500044
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/6917
专题健康与遗传心理学研究室
通讯作者Zheng, XG (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Scripps Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA
3.CapitalBio Corp, Beijing 102206, Peoples R China
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Liang, Jing,Chen, Ji-Huan,Chen, Xiao-Hong,et al. Gene expression of conditioned locomotion and context-specific locomotor sensitization controlled by morphine-associated environment[J]. BEHAVIOURAL BRAIN RESEARCH,2011,216(1):321-331.
APA Liang, Jing,Chen, Ji-Huan,Chen, Xiao-Hong,Peng, Yong-Hua,Zheng, Xi-Geng,&Zheng, XG .(2011).Gene expression of conditioned locomotion and context-specific locomotor sensitization controlled by morphine-associated environment.BEHAVIOURAL BRAIN RESEARCH,216(1),321-331.
MLA Liang, Jing,et al."Gene expression of conditioned locomotion and context-specific locomotor sensitization controlled by morphine-associated environment".BEHAVIOURAL BRAIN RESEARCH 216.1(2011):321-331.
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