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Prolonged high-altitude residence impacts verbal working memory: an fMRI study
Yan, Xiaodan2,3,4; Zhang, Jiaxing1,2; Gong, Qiyong5; Weng, Xuchu2; Zhang, JX (reprint author), Xiamen Univ, Dept Physiol, Coll Med, Xiamen, Peoples R China.
2011-02-01
Source PublicationEXPERIMENTAL BRAIN RESEARCH
ISSN0014-4819
SubtypeArticle
Volume208Issue:3Pages:437-445
Contribution Rank1
AbstractOxygen is critical to normal brain functioning and development. In high altitude where the oxygen concentration and pressure are very low, human cognitive capability such as working memory has been found to be jeopardized. Such effect might persist with long-term high-altitude residence. The current study investigated the verbal working memory of 28 high-altitude residents with blood level oxygen dependent (BOLD) functional magnetic resonance imaging (fMRI), in contrast with that of the 30 sea level residents. All of the subjects were healthy college students, matched on their age, gender ratio and social-economic status; they also did not show any difference on their hemoglobin level. The high-altitude subjects showed longer reaction time and decreased response accuracy in behavioral performance. Both groups showed activation in the typical regions associated with the 2-back verbal working memory task, and the behavioral performance of both groups showed significant correlations with the BOLD signal change amplitude and Granger causality values (as a measure of the interregional effective connectivity) between these regions. With group comparison statistics, the high-altitude subjects showed decreased activation at the inferior and middle frontal gyrus, the middle occipital and the lingual gyrus, the pyramis of vermis, as well as the thalamus. In conclusion, the current study revealed impairment in verbal working memory among high-altitude residents, which might be associated with the impact of prolonged chronic hypoxia exposure on the brain functionality.
KeywordWorking memory N-back Verbal Granger causality Effective connectivity fMRI
Subject AreaCognitive Psychology,Environmental Psychology
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Indexed BySCI
Language英语
Funding Project二室翁旭初课题组
WOS IDWOS:000286117700011
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/6933
Collection认知与发展心理学研究室
Corresponding AuthorZhang, JX (reprint author), Xiamen Univ, Dept Physiol, Coll Med, Xiamen, Peoples R China.
Affiliation1.Xiamen Univ, Dept Physiol, Coll Med, Xiamen, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
3.Rensselaer Polytech Inst, Dept Cognit Sci, Troy, NY USA
4.NYU, Langone Med Ctr, New York, NY USA
5.Sichuan Univ, Huaxi Magnet Resonance Res Ctr, W China Hosp, Chengdu 610064, Peoples R China
Recommended Citation
GB/T 7714
Yan, Xiaodan,Zhang, Jiaxing,Gong, Qiyong,et al. Prolonged high-altitude residence impacts verbal working memory: an fMRI study[J]. EXPERIMENTAL BRAIN RESEARCH,2011,208(3):437-445.
APA Yan, Xiaodan,Zhang, Jiaxing,Gong, Qiyong,Weng, Xuchu,&Zhang, JX .(2011).Prolonged high-altitude residence impacts verbal working memory: an fMRI study.EXPERIMENTAL BRAIN RESEARCH,208(3),437-445.
MLA Yan, Xiaodan,et al."Prolonged high-altitude residence impacts verbal working memory: an fMRI study".EXPERIMENTAL BRAIN RESEARCH 208.3(2011):437-445.
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