Cerebral and functional adaptation with chronic hypoxia exposure: A multi-modal MRI study
Yan, Xiaodan2,3; Zhang, Jiaxing1,2; Shi, Jinfu2; Gong, Qiyong4; Weng, Xuchu2; Weng XC(翁旭初)
2010-08-12
发表期刊BRAIN RESEARCH
ISSN0006-8993
文章类型Article
卷号1348期号:1348页码:21-29
摘要The current study obtained multi-modal MRI data from 28 immigrant high altitude (HA) young adults who were born and grew up at Qinghai-Tibetan plateau matched with 28 matched sea level (SL) controls. We compared their regional gray matter volumes (VBM) and white matter quality (DAI FA values) as well as resting state brain activity (Regional Homogeneity (ReHo) of BOLD-fMRI). We found that HA residents showed decreased gray matter volume at bilateral anterior insula, bilateral prefrontal cortex, the left precentral, the left cingulate and the right lingual cortex; accompanied by changed FA and ReHo values in relevant and other regions. The resting state activity at the hippocampus and the right insula were increasing with SL relocation. The HA subjects performed worse on a series of working memory tasks, with the ReHo values of several regions as significant predictors of their performance. This study demonstrated the cerebral and functional modifications with chronic high altitude hypoxia. (C) 2010 Elsevier B.V. All rights reserved.
关键词Hypoxia VBM DTI ReHo Resting state BOLD fMRI Plasticity
学科领域认知心理学
收录类别SCI
语种英语
资助项目二室翁旭初课题组
WOS记录号WOS:000281222400003
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/6965
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Weng XC(翁旭初)
作者单位1.Xiamen Univ, Coll Med, Dept Physiol, Xiamen 361005, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
3.NYU, Langone Med Ctr, New York, NY 10016 USA
4.Sichuan Univ, W China Hosp, Huaxi Magnet Resonance Res Ctr, Chengdu 610041, Peoples R China
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Yan, Xiaodan,Zhang, Jiaxing,Shi, Jinfu,et al. Cerebral and functional adaptation with chronic hypoxia exposure: A multi-modal MRI study[J]. BRAIN RESEARCH,2010,1348(1348):21-29.
APA Yan, Xiaodan,Zhang, Jiaxing,Shi, Jinfu,Gong, Qiyong,Weng, Xuchu,&翁旭初.(2010).Cerebral and functional adaptation with chronic hypoxia exposure: A multi-modal MRI study.BRAIN RESEARCH,1348(1348),21-29.
MLA Yan, Xiaodan,et al."Cerebral and functional adaptation with chronic hypoxia exposure: A multi-modal MRI study".BRAIN RESEARCH 1348.1348(2010):21-29.
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