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Cerebral and functional adaptation with chronic hypoxia exposure: A multi-modal MRI study
Yan, Xiaodan2,3; Zhang, Jiaxing1,2; Shi, Jinfu2; Gong, Qiyong4; Weng, Xuchu2; Weng XC(翁旭初)
2010-08-12
Source PublicationBRAIN RESEARCH
ISSN0006-8993
SubtypeArticle
Volume1348Issue:1348Pages:21-29
AbstractThe current study obtained multi-modal MRI data from 28 immigrant high altitude (HA) young adults who were born and grew up at Qinghai-Tibetan plateau matched with 28 matched sea level (SL) controls. We compared their regional gray matter volumes (VBM) and white matter quality (DAI FA values) as well as resting state brain activity (Regional Homogeneity (ReHo) of BOLD-fMRI). We found that HA residents showed decreased gray matter volume at bilateral anterior insula, bilateral prefrontal cortex, the left precentral, the left cingulate and the right lingual cortex; accompanied by changed FA and ReHo values in relevant and other regions. The resting state activity at the hippocampus and the right insula were increasing with SL relocation. The HA subjects performed worse on a series of working memory tasks, with the ReHo values of several regions as significant predictors of their performance. This study demonstrated the cerebral and functional modifications with chronic high altitude hypoxia. (C) 2010 Elsevier B.V. All rights reserved.
KeywordHypoxia VBM DTI ReHo Resting state BOLD fMRI Plasticity
Subject Area认知心理学
Indexed BySCI
Language英语
Funding Project二室翁旭初课题组
WOS IDWOS:000281222400003
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/6965
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorWeng XC(翁旭初)
Affiliation1.Xiamen Univ, Coll Med, Dept Physiol, Xiamen 361005, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
3.NYU, Langone Med Ctr, New York, NY 10016 USA
4.Sichuan Univ, W China Hosp, Huaxi Magnet Resonance Res Ctr, Chengdu 610041, Peoples R China
Recommended Citation
GB/T 7714
Yan, Xiaodan,Zhang, Jiaxing,Shi, Jinfu,et al. Cerebral and functional adaptation with chronic hypoxia exposure: A multi-modal MRI study[J]. BRAIN RESEARCH,2010,1348(1348):21-29.
APA Yan, Xiaodan,Zhang, Jiaxing,Shi, Jinfu,Gong, Qiyong,Weng, Xuchu,&翁旭初.(2010).Cerebral and functional adaptation with chronic hypoxia exposure: A multi-modal MRI study.BRAIN RESEARCH,1348(1348),21-29.
MLA Yan, Xiaodan,et al."Cerebral and functional adaptation with chronic hypoxia exposure: A multi-modal MRI study".BRAIN RESEARCH 1348.1348(2010):21-29.
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