Anterior Cingulate Activity and the Self in Disorders of Consciousness
Qin, Pengmin1; Di, Haibo2; Liu, Yijun3,4; Yu, Senming5; Gong, Qiyong6; Duncan, Niall7; Weng, Xuchu1; Laureys, Steven8,9; Northoff, Georg7; Weng XC(翁旭初)
2010-12-01
发表期刊HUMAN BRAIN MAPPING
ISSN1065-9471
文章类型Article
卷号31期号:12页码:1993-2002
摘要Objectives: The aim of this study was to investigate the relationship between medial cortical activation and the presence of self and consciousness in healthy subjects and patients with vegetative state and minimally conscious state using functional magnetic resonance imaging (fMRI). Experiment design: We first conducted two fMRI experiments in healthy subjects to identify brain regions specifically associated with self-perception through the use of different auditory stimuli that had different grades of self-relatedness. We then applied these regions as functional localizers to examine the relationship between neural activity changes during self-relatedness and consciousness level in the patients with disorders of consciousness (DOC). Principal observations: We demonstrated recruitment of various anterior medial cortical regions including the anterior cingulate cortex (ACC) in healthy subjects during auditory perception of self-related stimuli. We further showed that patients with DOC showed signal changes in the ACC during auditory perception of self-related stimuli. Finally, it was shown that these signal changes correlate with the level of consciousness in the patients with DOC. Conclusion: The degree of consciousness in patients with DOC was correlated with neural activity in the ACC induced by self-related stimuli. Our results not only shed light on the pathophysiology of DOC, but may also suggest a useful neural, and thus diagnostic, marker of the dysfunction of consciousness in vegetative patients. Hum Brain Mapp 31:1993-2002, 2010. (C) 2010 Wiley-Liss, Inc.
关键词minimally conscious state vegetative state own name anterior cingulate cortex self
学科领域认知神经科学
收录类别SCI ; SSCI
语种英语
资助项目二室翁旭初课题组
WOS记录号WOS:000285259500014
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/6969
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Weng XC(翁旭初)
作者单位1.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
2.Hangzhou Normal Univ, Vegetat State & Consciousness Sci Inst, Hangzhou 310000, Zhejiang, Peoples R China
3.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32611 USA
4.Univ Florida, Dept Neurosci, McKnight Brain Inst, Gainesville, FL 32610 USA
5.Wujing Hosp Hangzhou City, Rehabil Ctr Brain Damage, Hangzhou 310000, Zhejiang, Peoples R China
6.W China Hosp Sichuan Univ, Dept Radiol, HMRRC, Chengdu 610000, Peoples R China
7.Univ Ottawa, Mental Hlth Res Inst, Ottawa, ON, Canada
8.Univ Liege, Coma Sci Grp, Cyclotron Res Ctr, B-4000 Liege, Belgium
9.Univ Liege, Dept Neurol, B-4000 Liege, Belgium
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GB/T 7714
Qin, Pengmin,Di, Haibo,Liu, Yijun,et al. Anterior Cingulate Activity and the Self in Disorders of Consciousness[J]. HUMAN BRAIN MAPPING,2010,31(12):1993-2002.
APA Qin, Pengmin.,Di, Haibo.,Liu, Yijun.,Yu, Senming.,Gong, Qiyong.,...&翁旭初.(2010).Anterior Cingulate Activity and the Self in Disorders of Consciousness.HUMAN BRAIN MAPPING,31(12),1993-2002.
MLA Qin, Pengmin,et al."Anterior Cingulate Activity and the Self in Disorders of Consciousness".HUMAN BRAIN MAPPING 31.12(2010):1993-2002.
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