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Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schzophrenia revealed by rFMRI
Su Lui; Tao Li; Wei Deng; Lijun Jiang; Qizhu Wu; Hehan Tang; Qiang Yue; Xiaoqi Huang; Raymond C. Chan; David A. Collier; Shashwath A. Meda; Godfrey Pearlson; Andrea Mechelli; John A. Sweeney; Qiyong Gong
2010
Source PublicationArchives of General Psychiatry
ISSN0003-990X
Volume67Issue:8Pages:783-792
AbstractContext Most of what we know about antipsychotic drug effects is at the receptor level, distal from the neural systemeffects that mediate their clinical efficacy. Studying cerebral function in antipsychotic-naive patients with schizophreniabefore and after pharmacotherapy can enhance understanding of the therapeutic mechanisms of these clinically effective treatments. Objective To examine alterations of regional and neural network function in antipsychotic-naive patients with first-episodeschizophrenia before and after treatment with second-generation antipsychotic medication. Design Case-control study. Setting Huaxi MR Research Center and Mental Health Centre of the West China Hospital. Participants Thirty-four antipsychotic-naive patients with first-episode schizophrenia were scanned using gradient-echoecho-planar imaging while in a resting state. After 6 weeks of antipsychotic treatment, patients were rescanned. Thirty-fourmatched healthy control subjects were studied at baseline for comparison purposes. Main Outcome Measures The amplitude of low-frequency fluctuations (ALFF) of blood oxygen level–dependent signals, believed to reflect spontaneous neural activity, was used to characterize regional cerebral function. Functional connectivity across brain regions was evaluated using a seed voxel correlation approach and an independent component analysis. Changes in these measures after treatment were examined to characterize effects of antipsychotic drugs on regional function and functional integration. Results After short-term treatment with second-generation antipsychotic medications, patients showed increased ALFF, particularly in the bilateral prefrontal and parietal cortex, left superior temporal cortex, and right caudate nucleus. Increased regional ALFF was associated with a reduction of clinical symptoms, and a widespread attenuation in functional connectivity was observed that was correlated with increased regional ALFF. Conclusions We demonstrate for the first time, to our knowledge, that widespread increased regional synchronous neural activity occurs after antipsychotic therapy, accompanied by decreased integration of function across widely distributed neural networks. These findings contribute to the understanding of the complex systems-level effects of antipsychotic drugs.
Subject Area医学心理学
Indexed BySCI
Language英语
Funding Project一室陈楚侨课题组
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/6997
Collection中国科学院心理研究所回溯数据库(1956-2010)
Recommended Citation
GB/T 7714
Su Lui,Tao Li,Wei Deng,et al. Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schzophrenia revealed by rFMRI[J]. Archives of General Psychiatry,2010,67(8):783-792.
APA Su Lui.,Tao Li.,Wei Deng.,Lijun Jiang.,Qizhu Wu.,...&Qiyong Gong.(2010).Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schzophrenia revealed by rFMRI.Archives of General Psychiatry,67(8),783-792.
MLA Su Lui,et al."Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schzophrenia revealed by rFMRI".Archives of General Psychiatry 67.8(2010):783-792.
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