Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schzophrenia revealed by rFMRI

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	Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schzophrenia revealed by rFMRI
	Su Lui; Tao Li; Wei Deng; Lijun Jiang; Qizhu Wu; Hehan Tang; Qiang Yue; Xiaoqi Huang; Raymond C. Chan; David A. Collier; Shashwath A. Meda; Godfrey Pearlson; Andrea Mechelli; John A. Sweeney; Qiyong Gong
摘要	Context Most of what we know about antipsychotic drug effects is at the receptor level, distal from the neural systemeffects that mediate their clinical efficacy. Studying cerebral function in antipsychotic-naive patients with schizophreniabefore and after pharmacotherapy can enhance understanding of the therapeutic mechanisms of these clinically effective treatments. Objective To examine alterations of regional and neural network function in antipsychotic-naive patients with first-episodeschizophrenia before and after treatment with second-generation antipsychotic medication. Design Case-control study. Setting Huaxi MR Research Center and Mental Health Centre of the West China Hospital. Participants Thirty-four antipsychotic-naive patients with first-episode schizophrenia were scanned using gradient-echoecho-planar imaging while in a resting state. After 6 weeks of antipsychotic treatment, patients were rescanned. Thirty-fourmatched healthy control subjects were studied at baseline for comparison purposes. Main Outcome Measures The amplitude of low-frequency fluctuations (ALFF) of blood oxygen level–dependent signals, believed to reflect spontaneous neural activity, was used to characterize regional cerebral function. Functional connectivity across brain regions was evaluated using a seed voxel correlation approach and an independent component analysis. Changes in these measures after treatment were examined to characterize effects of antipsychotic drugs on regional function and functional integration. Results After short-term treatment with second-generation antipsychotic medications, patients showed increased ALFF, particularly in the bilateral prefrontal and parietal cortex, left superior temporal cortex, and right caudate nucleus. Increased regional ALFF was associated with a reduction of clinical symptoms, and a widespread attenuation in functional connectivity was observed that was correlated with increased regional ALFF. Conclusions We demonstrate for the first time, to our knowledge, that widespread increased regional synchronous neural activity occurs after antipsychotic therapy, accompanied by decreased integration of function across widely distributed neural networks. These findings contribute to the understanding of the complex systems-level effects of antipsychotic drugs.
学科领域	医学心理学
	2010
语种	英语
发表期刊	Archives of General Psychiatry
ISSN	0003-990X
卷号	67 期号:8 页码:783-792
收录类别	SCI
资助项目	一室陈楚侨课题组
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/6997
专题	中国科学院心理研究所回溯数据库(1956-2010)
推荐引用方式 GB/T 7714	Su Lui,Tao Li,Wei Deng,et al. Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schzophrenia revealed by rFMRI[J]. Archives of General Psychiatry,2010,67(8):783-792.
APA	Su Lui.,Tao Li.,Wei Deng.,Lijun Jiang.,Qizhu Wu.,...&Qiyong Gong.(2010).Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schzophrenia revealed by rFMRI.Archives of General Psychiatry,67(8),783-792.
MLA	Su Lui,et al."Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schzophrenia revealed by rFMRI".Archives of General Psychiatry 67.8(2010):783-792.

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