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Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats
Shao, Feng1; Han, Xiao1; Li, Nanxin1,2; Wang, Weiwen3; Wang WW(王玮文)
2010-12-15
Source PublicationEUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
SubtypeArticle
Volume649Issue:1-3Pages:202-205
AbstractAdolescence is a critical period for neurodevelopment Disturbances during adolescence have significant deleterious effects on brain function and animal behavior Latent inhibition refers to the process in which pre exposure to a stimulus retards subsequent conditioning of this stimulus Previous studies demonstrate that adolescent social isolation significantly impairs latent inhibition and disrupts cortical dopamine and glutamate neurotransmission However It remains elusive whether dopamine agonism during adolescence has any effect on latent inhibition or cortical glutamate activity In the current study adolescent Wistar rats were subjected to chronic dopamine agonist apomorphine treatment (1 mg/kg for 14 days) Latent inhibition and metabotropic glutamate receptor 5 (mGluR5) expression levels were examined at adulthood The results demonstrate that adolescent chronic apomorphine treatment severely impairs latent inhibition and decreases mGluR5 receptor expression in the prefrontal cortex This study provides further evidence that pubertal dopaminergic deviation could result in schizophrenic-like behavioral and neurochemical abnormalities (C) 2010 Elsevier B V All rights reserved
KeywordAdolescent Apomorphine Dopamine Glutamate Latent inhibition Schizophrenia
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
Funding Project一室林文娟课题组
WOS IDWOS:000284294000027
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/7019
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorWang WW(王玮文)
Affiliation1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06508 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Shao, Feng,Han, Xiao,Li, Nanxin,et al. Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,649(1-3):202-205.
APA Shao, Feng,Han, Xiao,Li, Nanxin,Wang, Weiwen,&王玮文.(2010).Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats.EUROPEAN JOURNAL OF PHARMACOLOGY,649(1-3),202-205.
MLA Shao, Feng,et al."Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats".EUROPEAN JOURNAL OF PHARMACOLOGY 649.1-3(2010):202-205.
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