Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats
Shao, Feng1; Han, Xiao1; Li, Nanxin1,2; Wang, Weiwen3; Wang WW(王玮文)
2010-12-15
发表期刊EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
文章类型Article
卷号649期号:1-3页码:202-205
摘要Adolescence is a critical period for neurodevelopment Disturbances during adolescence have significant deleterious effects on brain function and animal behavior Latent inhibition refers to the process in which pre exposure to a stimulus retards subsequent conditioning of this stimulus Previous studies demonstrate that adolescent social isolation significantly impairs latent inhibition and disrupts cortical dopamine and glutamate neurotransmission However It remains elusive whether dopamine agonism during adolescence has any effect on latent inhibition or cortical glutamate activity In the current study adolescent Wistar rats were subjected to chronic dopamine agonist apomorphine treatment (1 mg/kg for 14 days) Latent inhibition and metabotropic glutamate receptor 5 (mGluR5) expression levels were examined at adulthood The results demonstrate that adolescent chronic apomorphine treatment severely impairs latent inhibition and decreases mGluR5 receptor expression in the prefrontal cortex This study provides further evidence that pubertal dopaminergic deviation could result in schizophrenic-like behavioral and neurochemical abnormalities (C) 2010 Elsevier B V All rights reserved
关键词Adolescent Apomorphine Dopamine Glutamate Latent inhibition Schizophrenia
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
资助项目一室林文娟课题组
WOS记录号WOS:000284294000027
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/7019
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Wang WW(王玮文)
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06508 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Shao, Feng,Han, Xiao,Li, Nanxin,et al. Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,649(1-3):202-205.
APA Shao, Feng,Han, Xiao,Li, Nanxin,Wang, Weiwen,&王玮文.(2010).Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats.EUROPEAN JOURNAL OF PHARMACOLOGY,649(1-3),202-205.
MLA Shao, Feng,et al."Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats".EUROPEAN JOURNAL OF PHARMACOLOGY 649.1-3(2010):202-205.
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