Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors | |
Shi, Miao2,3; Qi, Wei-Jing1; Gao, Ge1; Wang, Jin-Yan1; Luo, Fei1,2,3; Wang JY(王锦琰) | |
心理所单位排序 | 1 |
摘要 | Clinical observations suggest that depressed patients were less sensitive to experimental pain than healthy subjects. However, few animal studies are reported concerning the association of depression and pain. The purpose of this study was to investigate the effects of unpredictable chronic mild stress (UCMS) induced depression on the perceived intensity of painful stimulation in rats. We measured the thermal and mechanical paw withdrawal thresholds (PWT) of normal and spinal nerve ligated (SNL) rats using hot plate test and von Frey test, respectively. The results showed that rats exposed to UCMS exhibited significantly higher thermal and mechanical pain thresholds in comparison to the non-depressed controls. In particular, the PWT of the SNL group was restored to nearly normal level after three weeks of UCMS, and even comparable to that of the control group. These results strongly suggest that the depressed subjects have decreased sensitivity to externally applied noxious stimulation, which is consistent with our previous findings. (C) 2010 Elsevier B.V. All rights reserved. |
关键词 | Unpredictable chronic mild stress Depression Hot plate test Neuropathic pain Von Frey filament Allodynia |
学科领域 | 医学心理学 |
2010-09-24 | |
语种 | 英语 |
DOI | 10.1016/j.brainres.2010.07.023 |
发表期刊 | BRAIN RESEARCH |
ISSN | 0006-8993 |
卷号 | 1353页码:225-233 |
期刊论文类型 | Article |
收录类别 | SCI |
资助项目 | 一室罗非课题组 |
WOS记录号 | WOS:000282419500023 |
Q分类 | Q3 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/7023 |
专题 | 中国科学院心理研究所回溯数据库(1956-2010) |
通讯作者 | Wang JY(王锦琰) |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Peking Univ Hlth Sci, Neurosci Res Inst, Beijing, Peoples R China 3.Peking Univ Hlth Sci, Dept Neurobiol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Shi, Miao,Qi, Wei-Jing,Gao, Ge,et al. Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors[J]. BRAIN RESEARCH,2010,1353:225-233. |
APA | Shi, Miao,Qi, Wei-Jing,Gao, Ge,Wang, Jin-Yan,Luo, Fei,&王锦琰.(2010).Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors.BRAIN RESEARCH,1353,225-233. |
MLA | Shi, Miao,et al."Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors".BRAIN RESEARCH 1353(2010):225-233. |
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