Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors
Shi, Miao2,3; Qi, Wei-Jing1; Gao, Ge1; Wang, Jin-Yan1; Luo, Fei1,2,3; Wang JY(王锦琰)
2010-09-24
发表期刊BRAIN RESEARCH
ISSN0006-8993
文章类型Article
卷号1353页码:225-233
Q分类Q3
产权排序1
摘要

Clinical observations suggest that depressed patients were less sensitive to experimental pain than healthy subjects. However, few animal studies are reported concerning the association of depression and pain. The purpose of this study was to investigate the effects of unpredictable chronic mild stress (UCMS) induced depression on the perceived intensity of painful stimulation in rats. We measured the thermal and mechanical paw withdrawal thresholds (PWT) of normal and spinal nerve ligated (SNL) rats using hot plate test and von Frey test, respectively. The results showed that rats exposed to UCMS exhibited significantly higher thermal and mechanical pain thresholds in comparison to the non-depressed controls. In particular, the PWT of the SNL group was restored to nearly normal level after three weeks of UCMS, and even comparable to that of the control group. These results strongly suggest that the depressed subjects have decreased sensitivity to externally applied noxious stimulation, which is consistent with our previous findings. (C) 2010 Elsevier B.V. All rights reserved.

关键词Unpredictable chronic mild stress Depression Hot plate test Neuropathic pain Von Frey filament Allodynia
学科领域医学心理学
DOI10.1016/j.brainres.2010.07.023
收录类别SCI
语种英语
资助项目一室罗非课题组
WOS记录号WOS:000282419500023
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/7023
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Wang JY(王锦琰)
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ Hlth Sci, Neurosci Res Inst, Beijing, Peoples R China
3.Peking Univ Hlth Sci, Dept Neurobiol, Beijing, Peoples R China
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GB/T 7714
Shi, Miao,Qi, Wei-Jing,Gao, Ge,et al. Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors[J]. BRAIN RESEARCH,2010,1353:225-233.
APA Shi, Miao,Qi, Wei-Jing,Gao, Ge,Wang, Jin-Yan,Luo, Fei,&王锦琰.(2010).Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors.BRAIN RESEARCH,1353,225-233.
MLA Shi, Miao,et al."Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors".BRAIN RESEARCH 1353(2010):225-233.
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