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Morphine induces Beclin 1-and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus
Zhao, Lixia1,2; Zhu, Yushan1,3; Wang, Dongmei4; Chen, Ming1; Gao, Ping1; Xiao, Weiming5; Rao, Guanhua3; Wang, Xiaohui1; Jin, Haijing1; Xu, Lin6; Sui, Nan4; Chen, Quan1,3; Sui N(隋南)
2010-04-01
Source PublicationAUTOPHAGY
ISSN1554-8627
SubtypeArticle
Volume6Issue:3Pages:386-394
AbstractChronic exposure to morphine can induce drug addiction and neural injury, but the exact mechanism is not fully understood. Here we show that morphine induces autophagy in neuroblastoma SH-SY5Y cells and in the rat hippocampus. Pharmacological approach shows that this effect appears to be mediated by PTX-sensitive G protein-coupled receptors signaling cascade. Morphine increases Beclin 1 expression and reduces the interaction between Beclin 1 and Bcl-2, thus releasing Beclin 1 for its pro-autophagic activity. Bcl-2 overexpression inhibits morphine-induced autophagy, whereas knockdown of Beclin 1 or knockout of ATG5 prevents morphine-induced autophagy. In addition, chronic treatment with morphine induces cell death, which is increased by autophagy inhibition through Beclin 1 RNAi. Our data are the first to reveal that Beclin 1 and ATG5 play key roles in morphine-induced autophagy, which may contribute to morphine-induced neuronal injury.
Keywordmorphine autophagy cell death Beclin 1 ATG5
Subject Area医学心理学
Indexed BySCI
Language英语
Funding Project一室隋南课题组
WOS IDWOS:000276198200009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/7033
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorSui N(隋南)
Affiliation1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Lab Apoptosis & Canc Biol, Beijing 100864, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100864, Peoples R China
3.Nankai Univ, Coll Life Sci, Tianjin, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100864, Peoples R China
5.Peking Univ, Coll Life Sci, Beijing, Peoples R China
6.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Lixia,Zhu, Yushan,Wang, Dongmei,et al. Morphine induces Beclin 1-and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus[J]. AUTOPHAGY,2010,6(3):386-394.
APA Zhao, Lixia.,Zhu, Yushan.,Wang, Dongmei.,Chen, Ming.,Gao, Ping.,...&隋南.(2010).Morphine induces Beclin 1-and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus.AUTOPHAGY,6(3),386-394.
MLA Zhao, Lixia,et al."Morphine induces Beclin 1-and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus".AUTOPHAGY 6.3(2010):386-394.
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