PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice
Han, Jin1,2; Li, Yonghui1; Wang, Dongmei1; Wei, Chuguang1,2; Yang, Xiaoyan1; Sui, Nan1
First AuthorHan, Jin
2010-09-10
Source PublicationEUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
SubtypeArticle
Volume642Issue:1-3Pages:93-98
QuartileQ2
Contribution Rank1
Abstract

The long lasting addiction-related abnormal memory is one of the most important foundations for relapse. DNA methylation may be a possible mechanism for persistence of such memory. Here we injected the DNA methyltransferases (DNMTs) inhibitor, 5-aza-2-deoxycytidine (5-aza) into hippocampus CA1 area and prelimbic cortex during the stages of acquisition and expression of cocaine-induced place preference in C57BL/6 mice. Results showed that in CA1 DNA methylation inhibitors could restrain acquisition but had no impact on expression of the cocaine-induced conditioned place preference (CPP). On the contrary, in prelimbic cortex, 5-aza had no effect on acquisition but blocked expression. Our results indicated that DNA methylation in hippocampus is required for learning; while DNA methylation in prelimbic cortex is necessary for memory retrieval. The present finding is consistent with the role of the hippocampus as a structure contributing to cocaine-induced memory acquisition, and prelimbic cortex, a part of prefrontal cortex as an area responsible for cocaine-induced memory retrieval. In conclusion, DNA methylation does play an important role in drug-induced learning and memory although the detailed effect still calls for further research. (C) 2010 Elsevier B.V. All rights reserved.

KeywordDNA methylation Hippocampus Prelimbic cortex Cocaine Conditioned place preference
Subject Area医学心理学
DOI10.1016/j.ejphar.2010.05.050
Indexed BySCI
Language英语
Funding Project一室隋南课题组
WOS IDWOS:000280681500012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/7035
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorSui, Nan
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Han, Jin,Li, Yonghui,Wang, Dongmei,et al. Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,642(1-3):93-98.
APA Han, Jin,Li, Yonghui,Wang, Dongmei,Wei, Chuguang,Yang, Xiaoyan,&Sui, Nan.(2010).Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice.EUROPEAN JOURNAL OF PHARMACOLOGY,642(1-3),93-98.
MLA Han, Jin,et al."Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice".EUROPEAN JOURNAL OF PHARMACOLOGY 642.1-3(2010):93-98.
Files in This Item:
File Name/Size DocType Version Access License
Han-2010-Effect-of--(659KB)期刊论文出版稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Han, Jin]'s Articles
[Li, Yonghui]'s Articles
[Wang, Dongmei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Han, Jin]'s Articles
[Li, Yonghui]'s Articles
[Wang, Dongmei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Han, Jin]'s Articles
[Li, Yonghui]'s Articles
[Wang, Dongmei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Han-2010-Effect-of--aza--deoxycytidine-micro.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.