Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice
Han, Jin1,2; Li, Yonghui1; Wang, Dongmei1; Wei, Chuguang1,2; Yang, Xiaoyan1; Sui, Nan1
第一作者Han, Jin
2010-09-10
发表期刊EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
文章类型Article
卷号642期号:1-3页码:93-98
Q分类Q2
产权排序1
摘要

The long lasting addiction-related abnormal memory is one of the most important foundations for relapse. DNA methylation may be a possible mechanism for persistence of such memory. Here we injected the DNA methyltransferases (DNMTs) inhibitor, 5-aza-2-deoxycytidine (5-aza) into hippocampus CA1 area and prelimbic cortex during the stages of acquisition and expression of cocaine-induced place preference in C57BL/6 mice. Results showed that in CA1 DNA methylation inhibitors could restrain acquisition but had no impact on expression of the cocaine-induced conditioned place preference (CPP). On the contrary, in prelimbic cortex, 5-aza had no effect on acquisition but blocked expression. Our results indicated that DNA methylation in hippocampus is required for learning; while DNA methylation in prelimbic cortex is necessary for memory retrieval. The present finding is consistent with the role of the hippocampus as a structure contributing to cocaine-induced memory acquisition, and prelimbic cortex, a part of prefrontal cortex as an area responsible for cocaine-induced memory retrieval. In conclusion, DNA methylation does play an important role in drug-induced learning and memory although the detailed effect still calls for further research. (C) 2010 Elsevier B.V. All rights reserved.

关键词DNA methylation Hippocampus Prelimbic cortex Cocaine Conditioned place preference
学科领域医学心理学
DOI10.1016/j.ejphar.2010.05.050
收录类别SCI
语种英语
资助项目一室隋南课题组
WOS记录号WOS:000280681500012
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/7035
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Sui, Nan
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
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Han, Jin,Li, Yonghui,Wang, Dongmei,et al. Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,642(1-3):93-98.
APA Han, Jin,Li, Yonghui,Wang, Dongmei,Wei, Chuguang,Yang, Xiaoyan,&Sui, Nan.(2010).Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice.EUROPEAN JOURNAL OF PHARMACOLOGY,642(1-3),93-98.
MLA Han, Jin,et al."Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice".EUROPEAN JOURNAL OF PHARMACOLOGY 642.1-3(2010):93-98.
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