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Coexistence of Anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression
Li, Y.1,2; Zheng, X.1; Liang, J.1; Peng, Y.1,2; Zheng XG(郑希耕)
2010-03-01
Source PublicationBEHAVIOURAL PROCESSES
ISSN0376-6357
SubtypeArticle
Volume83Issue:3Pages:331-339
AbstractPrevious research demonstrated excessive decreases in reward sensitivity and increases in harm avoidance in depressed individuals. These results straightly lead to a hypothesis that depressed patients should avoid novelty or express reduced novelty-seeking behavior. Nevertheless, literature in this regard is inconsistent. Furthermore, whether the potentially altered novelty-associated behavior is dependent on changed anxiety/fear or related to altered goal-directed approaching tendency is unclear. Here, we tested novel object-approaching behavior in a free-exploration paradigm in chronic mild stress (CMS)-induced anhedonic and stress-resistant rats respectively. Other CMS-induced, emotional behaviors were also examined in a battery of behavioral tests including novel cage, exploration, locomotor activity and elevated plus maze (EPM). We found that compared with controls, stress-resistant rats who consistently showed lower anxiety level in EPM (time in open arms) and, open-field (OF) test (time in central area) showed no sign of enhanced novel object approaching behavior. To the contrary, the anhedonic ones who did not express any sign of reduced anxiety showed paradoxically intensified novelty-approaching behavior. We concluded that reduced anxiety would not necessarily lead to enhanced novelty-seeking behavior; anhedonia coexists with anxiety-independent, increased novelty-seeking behavior. The salient paradox of coexistence of anhedonia and increased novelty-seeking behavior was critically discussed. (C) 2010 Elsevier B.V. All rights reserved.
KeywordAnhedonia Anxiety Chronic mild stress Depression Novelty-seeking
Subject Area医学心理学
Indexed BySCI ; SSCI
Language英语
Funding Project一室郑希耕课题组
WOS IDWOS:000276666600015
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/7045
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorZheng XG(郑希耕)
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Lab Expt Clin Psychol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Y.,Zheng, X.,Liang, J.,et al. Coexistence of Anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression[J]. BEHAVIOURAL PROCESSES,2010,83(3):331-339.
APA Li, Y.,Zheng, X.,Liang, J.,Peng, Y.,&郑希耕.(2010).Coexistence of Anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression.BEHAVIOURAL PROCESSES,83(3),331-339.
MLA Li, Y.,et al."Coexistence of Anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression".BEHAVIOURAL PROCESSES 83.3(2010):331-339.
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