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The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects
Liang Jing1; Peng YongHua1,2; Ge XiaoXiang3; Zheng XiGeng1; Zheng XG(郑希耕)
2010-07-01
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
SubtypeArticle
Volume55Issue:19Pages:2016-2020
AbstractBoth conditioned responses (CRs) and sensitized behaviors induced by addictive drugs are considered to reflect drug-seeking motivation. Based on an excitatory conditioning model of behavioral sensitization, this work hypothesizes that conditioned locomotor activity and locomotor sensitization concomitantly occur using different drug treatment regimens. In the present study, conditioned locomotor activity and sensitized locomotion and stereotypy are assessed with pretreatment of two doses of morphine in a familiar or novel environment. When rats are trained with morphine (3 or 5 mg/kg) in an environment to which the animals are habituated, a CR but not contextual sensitization is induced when tested after 1 week of abstinence. When rats receive the 5 mg/kg dose of morphine immediately after placement into a novel environment, the same results are obtained, but when the drug dose is decreased to 3 mg/kg, both the CR and contextual sensitization are observed. Therefore, the sensitized behaviors, rather than the CR produced by morphine pretreatment, appear to be dependent on the drug treatment regimen and environmental novelty, suggesting that different mechanisms may be involved in the expression of the CR and contextual sensitization.
Keywordmorphine conditioning sensitization locomotion stereotypy
Subject Area医学心理学
Indexed BySCI
Language英语
Funding Project一室郑希耕课题组
WOS IDWOS:000279714300010
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/7047
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorZheng XG(郑希耕)
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Third Mil Med Univ, Chongqing 400038, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Liang Jing,Peng YongHua,Ge XiaoXiang,et al. The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects[J]. CHINESE SCIENCE BULLETIN,2010,55(19):2016-2020.
APA Liang Jing,Peng YongHua,Ge XiaoXiang,Zheng XiGeng,&郑希耕.(2010).The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects.CHINESE SCIENCE BULLETIN,55(19),2016-2020.
MLA Liang Jing,et al."The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects".CHINESE SCIENCE BULLETIN 55.19(2010):2016-2020.
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