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Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats
Wang, Ning1; Zhang, Yang2; Wang, Jin-Yan1; Gao, Ge1; Luo, Fei1; Luo F(罗非)
2010-06-01
Source PublicationNEUROSCIENCE BULLETIN
ISSN1673-7067
SubtypeArticle
Volume26Issue:3Pages:188-196
AbstractObjective To investigate the effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways. Methods Laser stimulation was employed to evoke nociceptive responses in rats under awake or anesthetic conditions. Pain-related neuronal activities were simultaneously recorded from the primary somatosensory cortex (SI), ventral posterolateral thalamus (VPL), anterior cingulate cortex (ACC), and medial dorsal thalamus (MD) with 4 eight-wire microelectrode arrays. Results Compared with the awake state, pentobarbital anesthesia significantly suppressed the neural activities induced by noxious laser stimulation. Meanwhile, the pain-evoked changes in the neuronal correlations between cortex and thalamus were suppressed in both medial and lateral pain pathways. In addition, the spontaneous firing rates in all the 4 areas were altered (including inhibition and excitation) under the condition of anesthesia. Conclusion The nociceptive processing in the brain can be dramatically changed by anesthesia, which indicates that there are considerable differences in the brain activities between awake and anesthetized states. It is better to employ awake animals for recording neural activity when investigating the sensory coding mechanisms, especially pain coding, in order to obtain data that precisely reflect the physiological state.
Keywordanesthesia laser, multiple single-unit recording
Subject Area健康心理学
Indexed BySCI
Language英语
Funding Project一室罗非课题组
WOS IDWOS:000295724200002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/7227
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorLuo F(罗非)
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Ning,Zhang, Yang,Wang, Jin-Yan,et al. Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats[J]. NEUROSCIENCE BULLETIN,2010,26(3):188-196.
APA Wang, Ning,Zhang, Yang,Wang, Jin-Yan,Gao, Ge,Luo, Fei,&罗非.(2010).Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats.NEUROSCIENCE BULLETIN,26(3),188-196.
MLA Wang, Ning,et al."Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats".NEUROSCIENCE BULLETIN 26.3(2010):188-196.
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