Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats
Wang, Ning1; Zhang, Yang2; Wang, Jin-Yan1; Gao, Ge1; Luo, Fei1; Luo F(罗非)
2010-06-01
发表期刊NEUROSCIENCE BULLETIN
ISSN1673-7067
文章类型Article
卷号26期号:3页码:188-196
摘要Objective To investigate the effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways. Methods Laser stimulation was employed to evoke nociceptive responses in rats under awake or anesthetic conditions. Pain-related neuronal activities were simultaneously recorded from the primary somatosensory cortex (SI), ventral posterolateral thalamus (VPL), anterior cingulate cortex (ACC), and medial dorsal thalamus (MD) with 4 eight-wire microelectrode arrays. Results Compared with the awake state, pentobarbital anesthesia significantly suppressed the neural activities induced by noxious laser stimulation. Meanwhile, the pain-evoked changes in the neuronal correlations between cortex and thalamus were suppressed in both medial and lateral pain pathways. In addition, the spontaneous firing rates in all the 4 areas were altered (including inhibition and excitation) under the condition of anesthesia. Conclusion The nociceptive processing in the brain can be dramatically changed by anesthesia, which indicates that there are considerable differences in the brain activities between awake and anesthetized states. It is better to employ awake animals for recording neural activity when investigating the sensory coding mechanisms, especially pain coding, in order to obtain data that precisely reflect the physiological state.
关键词anesthesia laser, multiple single-unit recording
学科领域健康心理学
收录类别SCI
语种英语
资助项目一室罗非课题组
WOS记录号WOS:000295724200002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/7227
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Luo F(罗非)
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
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Wang, Ning,Zhang, Yang,Wang, Jin-Yan,et al. Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats[J]. NEUROSCIENCE BULLETIN,2010,26(3):188-196.
APA Wang, Ning,Zhang, Yang,Wang, Jin-Yan,Gao, Ge,Luo, Fei,&罗非.(2010).Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats.NEUROSCIENCE BULLETIN,26(3),188-196.
MLA Wang, Ning,et al."Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats".NEUROSCIENCE BULLETIN 26.3(2010):188-196.
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