The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain
Su, Yuan-Lin1,2; Wang, Ning1; Gao, Ge1; Wang, Jin-Yan1; Luo, Fei1; Luo F(罗非)
2010-12-01
发表期刊NEUROSCIENCE BULLETIN
ISSN1673-7067
文章类型Article
卷号26期号:6页码:429-436
摘要Objective Recently, there has been growing interest in the interaction between depressive disorders and pain. The purpose of this study was to examine whether depression would lead to a decreased sensitivity to noxious stimuli in rats with spontaneous pain. Methods The olfactory bulbectomized rats were used as a model of depression. The depression-like behaviors were assessed by open field test and changes in body weight. Formalin solution was injected into the rat hindpaw to produce ongoing pain. Noxious thermal stimuli were applied onto the hindpaw contralateral to formalin injection, and the withdrawal thresholds were measured. Results In non-depressive rats, the formalin-treated paw developed hypoalgesia to noxious stimuli while the contralateral paw was not affected. The depressive rats, however, showed a significantly lower sensitivity to noxious thermal stimulus, represented as higher withdrawal thresholds of the contralateral paw, when compared to the non-depressive rats. Conclusion These results demonstrate that depression can alleviate the stimulus-evoked pain even in the context of formalin inflammatory pain, consistent with the previous clinical observations that patients suffering from both depression and persistent pain have decreased sensitivities to noxious experimental stimuli.
关键词depression evoked pain formalin olfactory bulbectomy thermal stimulation
学科领域健康心理学
收录类别SCI
语种英语
资助项目一室罗非课题组
WOS记录号WOS:000295725800001
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/7229
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Luo F(罗非)
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
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Su, Yuan-Lin,Wang, Ning,Gao, Ge,et al. The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain[J]. NEUROSCIENCE BULLETIN,2010,26(6):429-436.
APA Su, Yuan-Lin,Wang, Ning,Gao, Ge,Wang, Jin-Yan,Luo, Fei,&罗非.(2010).The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain.NEUROSCIENCE BULLETIN,26(6),429-436.
MLA Su, Yuan-Lin,et al."The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain".NEUROSCIENCE BULLETIN 26.6(2010):429-436.
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