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The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain
Su, Yuan-Lin1,2; Wang, Ning1; Gao, Ge1; Wang, Jin-Yan1; Luo, Fei1; Luo F(罗非)
2010-12-01
Source PublicationNEUROSCIENCE BULLETIN
ISSN1673-7067
SubtypeArticle
Volume26Issue:6Pages:429-436
AbstractObjective Recently, there has been growing interest in the interaction between depressive disorders and pain. The purpose of this study was to examine whether depression would lead to a decreased sensitivity to noxious stimuli in rats with spontaneous pain. Methods The olfactory bulbectomized rats were used as a model of depression. The depression-like behaviors were assessed by open field test and changes in body weight. Formalin solution was injected into the rat hindpaw to produce ongoing pain. Noxious thermal stimuli were applied onto the hindpaw contralateral to formalin injection, and the withdrawal thresholds were measured. Results In non-depressive rats, the formalin-treated paw developed hypoalgesia to noxious stimuli while the contralateral paw was not affected. The depressive rats, however, showed a significantly lower sensitivity to noxious thermal stimulus, represented as higher withdrawal thresholds of the contralateral paw, when compared to the non-depressive rats. Conclusion These results demonstrate that depression can alleviate the stimulus-evoked pain even in the context of formalin inflammatory pain, consistent with the previous clinical observations that patients suffering from both depression and persistent pain have decreased sensitivities to noxious experimental stimuli.
Keyworddepression evoked pain formalin olfactory bulbectomy thermal stimulation
Subject Area健康心理学
Indexed BySCI
Language英语
Funding Project一室罗非课题组
WOS IDWOS:000295725800001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/7229
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorLuo F(罗非)
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Su, Yuan-Lin,Wang, Ning,Gao, Ge,et al. The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain[J]. NEUROSCIENCE BULLETIN,2010,26(6):429-436.
APA Su, Yuan-Lin,Wang, Ning,Gao, Ge,Wang, Jin-Yan,Luo, Fei,&罗非.(2010).The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain.NEUROSCIENCE BULLETIN,26(6),429-436.
MLA Su, Yuan-Lin,et al."The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain".NEUROSCIENCE BULLETIN 26.6(2010):429-436.
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