Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults
Fan, Ming1; Liu, Bing1; Zhou, Yuan1,2; Zhen, Xiantong3; Xu, Cunlu3; Jiang, Tianzi1; Alzheimers Dis Neuroimaging Initia; Jiang; T. Z
2010-08-02
发表期刊NEUROSCIENCE LETTERS
ISSN0304-3940
文章类型Article
卷号479期号:3页码:332-336
摘要Previous studies have consistently suggested that the epsilon 4 allele of apolipoprotein E (APOE) gene is a major risk factor for Alzheimer's disease (AD). However, whether the epsilon 2 allele, a possible protective factor for AD, will express its protective effect in terms of cortical thickness in healthy elderly carriers is unclear. The goal of this study is to clarify the effects of APOE genotypes on cortical thickness in nondemented elderly subjects. We used 164 healthy, cognitively normal, elderly subjects, who were grouped into epsilon 2 carriers, epsilon 3 homozygotes, and epsilon 4 carriers respectively. The APOE epsilon 2 carriers had a significant thicker (corrected p < 0.05)cortical thickness in the superior temporal cortex compared with the epsilon 3 homozygotes. In addition to this area, the APOE epsilon 2 carriers had a significantly thicker region in the dorsolateral prefrontal cortex (corrected p < 0.05) than did the epsilon 4 carriers. These findings suggest that the different alleles of the APOE gene have distinct neuroanatomic effects in elderly healthy subjects and may play specific roles in the development of AD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词Cortical thickness Apolipoprotein E Alzheimer's disease
学科领域行为遗传学
收录类别SCI
语种英语
资助项目三室李纾课题组
WOS记录号WOS:000280100600032
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/7231
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Jiang; T. Z
作者单位1.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Ctr Social & Econ Behav, Inst Psychol, Beijing 100101, Peoples R China
3.Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China
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GB/T 7714
Fan, Ming,Liu, Bing,Zhou, Yuan,et al. Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults[J]. NEUROSCIENCE LETTERS,2010,479(3):332-336.
APA Fan, Ming.,Liu, Bing.,Zhou, Yuan.,Zhen, Xiantong.,Xu, Cunlu.,...&T. Z.(2010).Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults.NEUROSCIENCE LETTERS,479(3),332-336.
MLA Fan, Ming,et al."Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults".NEUROSCIENCE LETTERS 479.3(2010):332-336.
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