Peri-adolescence isolation rearing alters social behavior and nociception in rats
Meng, Qingxuan1; Li, Nanxin1,2; Han, Xiao1; Shao, Feng1; Wang, Weiwen3; Wang WW(王玮文); Feng Shao
2010-08-09
发表期刊NEUROSCIENCE LETTERS
ISSN0304-3940
文章类型Article
卷号480期号:1页码:25-29
摘要Social isolation results in fundamental behavioral abnormalities in rodents which models certain neuropsychiatric disorders such as schizophrenia. However, the developmental stage that is most vulnerable to social isolation is largely unknown. In the present study, we subjected weaning rats to a four-week peri-adolescence isolation rearing (PAIR) and then returned them to social rearing for an additional four weeks until adulthood. Open field locomotion, social interaction behavior, and acute pain sensitivity were examined at different time points. PAIR rats showed moderate hyperactivity towards a novel environment, an anxiogenic-like behavioral profile, and increased aggression and social interaction behavior, the last three of which could be restored by re-socialization procedure. In addition, PAIR animals showed significantly reduced pain sensitivity even after the re-socialization period. In summary, this study advances the use of pen-adolescent isolation rearing as an animal model to study neurodevelopmental manipulation induced behavioral abnormalities. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词Adolescent Anxiety Open field Pain sensitivity Social interaction Social isolation
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
资助项目一室林文娟课题组
WOS记录号WOS:000280471400007
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/7237
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Wang WW(王玮文); Feng Shao
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Yale Univ, Div Mol Psychiat, Dept Psychol, New Haven, CT 06508 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Meng, Qingxuan,Li, Nanxin,Han, Xiao,et al. Peri-adolescence isolation rearing alters social behavior and nociception in rats[J]. NEUROSCIENCE LETTERS,2010,480(1):25-29.
APA Meng, Qingxuan.,Li, Nanxin.,Han, Xiao.,Shao, Feng.,Wang, Weiwen.,...&Feng Shao.(2010).Peri-adolescence isolation rearing alters social behavior and nociception in rats.NEUROSCIENCE LETTERS,480(1),25-29.
MLA Meng, Qingxuan,et al."Peri-adolescence isolation rearing alters social behavior and nociception in rats".NEUROSCIENCE LETTERS 480.1(2010):25-29.
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