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Peri-adolescence isolation rearing alters social behavior and nociception in rats
Meng, Qingxuan1; Li, Nanxin1,2; Han, Xiao1; Shao, Feng1; Wang, Weiwen3; Wang WW(王玮文); Feng Shao
2010-08-09
Source PublicationNEUROSCIENCE LETTERS
ISSN0304-3940
SubtypeArticle
Volume480Issue:1Pages:25-29
AbstractSocial isolation results in fundamental behavioral abnormalities in rodents which models certain neuropsychiatric disorders such as schizophrenia. However, the developmental stage that is most vulnerable to social isolation is largely unknown. In the present study, we subjected weaning rats to a four-week peri-adolescence isolation rearing (PAIR) and then returned them to social rearing for an additional four weeks until adulthood. Open field locomotion, social interaction behavior, and acute pain sensitivity were examined at different time points. PAIR rats showed moderate hyperactivity towards a novel environment, an anxiogenic-like behavioral profile, and increased aggression and social interaction behavior, the last three of which could be restored by re-socialization procedure. In addition, PAIR animals showed significantly reduced pain sensitivity even after the re-socialization period. In summary, this study advances the use of pen-adolescent isolation rearing as an animal model to study neurodevelopmental manipulation induced behavioral abnormalities. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
KeywordAdolescent Anxiety Open field Pain sensitivity Social interaction Social isolation
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
Funding Project一室林文娟课题组
WOS IDWOS:000280471400007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/7237
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorWang WW(王玮文); Feng Shao
Affiliation1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Yale Univ, Div Mol Psychiat, Dept Psychol, New Haven, CT 06508 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Meng, Qingxuan,Li, Nanxin,Han, Xiao,et al. Peri-adolescence isolation rearing alters social behavior and nociception in rats[J]. NEUROSCIENCE LETTERS,2010,480(1):25-29.
APA Meng, Qingxuan.,Li, Nanxin.,Han, Xiao.,Shao, Feng.,Wang, Weiwen.,...&Feng Shao.(2010).Peri-adolescence isolation rearing alters social behavior and nociception in rats.NEUROSCIENCE LETTERS,480(1),25-29.
MLA Meng, Qingxuan,et al."Peri-adolescence isolation rearing alters social behavior and nociception in rats".NEUROSCIENCE LETTERS 480.1(2010):25-29.
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