Peri-adolescence isolation rearing alters social behavior and nociception in rats

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	Peri-adolescence isolation rearing alters social behavior and nociception in rats
	Meng, Qingxuan 1; Li, Nanxin 1,2; Han, Xiao 1; Shao, Feng 1; Wang, Weiwen3 ; Wang WW(王玮文); Feng Shao
摘要	Social isolation results in fundamental behavioral abnormalities in rodents which models certain neuropsychiatric disorders such as schizophrenia. However, the developmental stage that is most vulnerable to social isolation is largely unknown. In the present study, we subjected weaning rats to a four-week peri-adolescence isolation rearing (PAIR) and then returned them to social rearing for an additional four weeks until adulthood. Open field locomotion, social interaction behavior, and acute pain sensitivity were examined at different time points. PAIR rats showed moderate hyperactivity towards a novel environment, an anxiogenic-like behavioral profile, and increased aggression and social interaction behavior, the last three of which could be restored by re-socialization procedure. In addition, PAIR animals showed significantly reduced pain sensitivity even after the re-socialization period. In summary, this study advances the use of pen-adolescent isolation rearing as an animal model to study neurodevelopmental manipulation induced behavioral abnormalities. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词	Adolescent Anxiety Open field Pain sensitivity Social interaction Social isolation
学科领域	生理心理学/生物心理学
	2010-08-09
语种	英语
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	480 期号:1 页码:25-29
期刊论文类型	Article
收录类别	SCI
资助项目	一室林文娟课题组
WOS记录号	WOS:000280471400007
引用统计	被引频次：48[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/7237
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Wang WW(王玮文); Feng Shao
作者单位	1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Yale Univ, Div Mol Psychiat, Dept Psychol, New Haven, CT 06508 USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Meng, Qingxuan,Li, Nanxin,Han, Xiao,et al. Peri-adolescence isolation rearing alters social behavior and nociception in rats[J]. NEUROSCIENCE LETTERS,2010,480(1):25-29.
APA	Meng, Qingxuan.,Li, Nanxin.,Han, Xiao.,Shao, Feng.,Wang, Weiwen.,...&Feng Shao.(2010).Peri-adolescence isolation rearing alters social behavior and nociception in rats.NEUROSCIENCE LETTERS,480(1),25-29.
MLA	Meng, Qingxuan,et al."Peri-adolescence isolation rearing alters social behavior and nociception in rats".NEUROSCIENCE LETTERS 480.1(2010):25-29.

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