The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats
Wang, Wei1; Qi, Wei-Jing1,2; Xu, Yang1; Wang, Jin-Yan1; Luo, Fei1; Wang JY(王锦琰); Luo F(罗非)
2010-03-19
发表期刊NEUROSCIENCE LETTERS
ISSN0304-3940
文章类型Article
卷号472期号:2页码:143-147
摘要Although it has been accepted that depression and pain are common comorbidities, their interaction is not fully understood. The current study was aimed to investigate the effects of depression on both evoked pain behavior (thermal-induced nociception) and spontaneous pain behavior (formalin pain) using an olfactory bulbectomy (OB) rat model of depression. Emotional behaviors were assessed by open field and Morris water maze tests. The results showed that the depressed rats exhibited stronger tolerance to noxious thermal stimulation compared to non-depressed animals. In contrast, the spontaneous nociceptive behaviors induced by formalin injection were significantly enhanced in the OB rats in comparison to control rats. These results demonstrated that depression can have differential effects on stimulus-evoked pain and spontaneous pain, with alleviation in the former while aggravation in the latter. The present study has confirmed our previous findings that depression can inhibit evoked pain but facilitate spontaneous pain, and provides evidence that the OB depression model is a feasible model for studying the relationship between depression and pain. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词Depression Evoked pain Formalin Olfactory bulbectomy
学科领域认知神经科学
收录类别SCI
语种英语
资助项目一室罗非课题组
WOS记录号WOS:000276300300014
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/7241
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Wang JY(王锦琰); Luo F(罗非)
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
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Wang, Wei,Qi, Wei-Jing,Xu, Yang,et al. The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats[J]. NEUROSCIENCE LETTERS,2010,472(2):143-147.
APA Wang, Wei.,Qi, Wei-Jing.,Xu, Yang.,Wang, Jin-Yan.,Luo, Fei.,...&罗非.(2010).The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats.NEUROSCIENCE LETTERS,472(2),143-147.
MLA Wang, Wei,et al."The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats".NEUROSCIENCE LETTERS 472.2(2010):143-147.
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