The effects of morphine at different embryonic ages on memory consolidation and rewarding properties of morphine in day-old chicks
He, Xingu1,2; Bao, Yunfei1; Li, Yonghui1; Sui, Nan1; Sui N(隋南)
2010-09-20
发表期刊NEUROSCIENCE LETTERS
ISSN0304-3940
文章类型Article
卷号482期号:1页码:12-16
摘要Prenatal exposure to morphine can alter the capacities for learning and memory and the sensitivity to drugs of abuse in progeny. In the present study, we examined the effects of morphine during chick embryonic period of 5-8, 9-12, 13-16 and 17-20 on cognitive function and the sensitivities to morphine reward in the post-hatch chick, using the one-trial passive avoidance learning task and the conditioned place preference paradigm. It was observed that the injection of morphine (1 mg/kg of egg weight) during E5-8, but not in other three periods, significantly impaired intermediate- and long-term memory in one-day-old chicks. On the other hand, the chicks prenatally exposed to morphine during E17-20 remarkably not only acquired but also maintained the conditioned place preference induced by morphine. The present results suggest that there are two time-windows during development, which in the chick are around E5-8 and E17-20, when prenatal morphine exposure is likely to confer maximal risks for vulnerabilities to breakdown of memory consolidation and to morphine-induced reward in day-old chicks respectively. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词Prenatal morphine exposure One-trial passive avoidance learning task Conditioned place preference Sensitive embryonic period Day-old chicks
学科领域认知神经科学
收录类别SCI
语种英语
资助项目一室隋南课题组
WOS记录号WOS:000281274000003
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/7243
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Sui N(隋南)
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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He, Xingu,Bao, Yunfei,Li, Yonghui,et al. The effects of morphine at different embryonic ages on memory consolidation and rewarding properties of morphine in day-old chicks[J]. NEUROSCIENCE LETTERS,2010,482(1):12-16.
APA He, Xingu,Bao, Yunfei,Li, Yonghui,Sui, Nan,&隋南.(2010).The effects of morphine at different embryonic ages on memory consolidation and rewarding properties of morphine in day-old chicks.NEUROSCIENCE LETTERS,482(1),12-16.
MLA He, Xingu,et al."The effects of morphine at different embryonic ages on memory consolidation and rewarding properties of morphine in day-old chicks".NEUROSCIENCE LETTERS 482.1(2010):12-16.
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