i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study
Zhang, Kunlin; Cui, Sijia; Chang, Suhua; Zhang, Liuyan; Wang, Jing; Wang J(王晶)
2010-07-01
发表期刊NUCLEIC ACIDS RESEARCH
ISSN0305-1048
文章类型Article
卷号38期号:suppl 2页码:W90-W95
摘要Genome-wide association study (GWAS) is nowadays widely used to identify genes involved in human complex disease. The standard GWAS analysis examines SNPs/genes independently and identifies only a number of the most significant SNPs. It ignores the combined effect of weaker SNPs/genes, which leads to difficulties to explore biological function and mechanism from a systems point of view. Although gene set enrichment analysis (GSEA) has been introduced to GWAS to overcome these limitations by identifying the correlation between pathways/gene sets and traits, the heavy dependence on genotype data, which is not easily available for most published GWAS investigations, has led to limited application of it. In order to perform GSEA on a simple list of GWAS SNP P-values, we implemented GSEA by using SNP label permutation. We further improved GSEA (i-GSEA) by focusing on pathways/gene sets with high proportion of significant genes. To provide researchers an open platform to analyze GWAS data, we developed the i-GSEA4GWAS (improved GSEA for GWAS) web server. i-GSEA4GWAS implements the i-GSEA approach and aims to provide new insights in complex disease studies. i-GSEA4GWAS is freely available at http://gsea4gwas.psych.ac.cn/.
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
资助项目一室王晶课题组
WOS记录号WOS:000284148900016
引用统计
被引频次:108[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/7245
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Wang J(王晶)
作者单位Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
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GB/T 7714
Zhang, Kunlin,Cui, Sijia,Chang, Suhua,et al. i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study[J]. NUCLEIC ACIDS RESEARCH,2010,38(suppl 2):W90-W95.
APA Zhang, Kunlin,Cui, Sijia,Chang, Suhua,Zhang, Liuyan,Wang, Jing,&王晶.(2010).i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study.NUCLEIC ACIDS RESEARCH,38(suppl 2),W90-W95.
MLA Zhang, Kunlin,et al."i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study".NUCLEIC ACIDS RESEARCH 38.suppl 2(2010):W90-W95.
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