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Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus
Li, Yonghui1; Li, Sa; Wei, Chuguang2,3; Wang, Huiying2,3; Sui, Nan2; Kirouac, Gilbert J.1; Gilbert J. Kirouac
2010-03-01
Source PublicationPHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN0091-3057
SubtypeArticle
Volume95Issue:1Pages:121-128
AbstractThe paraventricular nucleus of the midline thalamus (PVT) innervates areas of the extended amygdala known to play a key role in the expression of emotional behaviors. In this study, microinjections of orexins (hypocretins), which have excitatory actions on neurons in the PVT, in the midline thalamus were used to investigate if the PVT modulates the expression of emotional behavior in the open field. First, the approach-avoidance tendency (number and duration of visit to the center area) associated with novelty was examined in orexin treated rats before and after placing a novel object in the center of the open field. Second, the expression of ethological behaviors (rearing, locomotion, freezing, and grooming) in the open field was used to determine the effects of orexins on emotionality. Microinjections of orexin-A (OXA) or orexin-B (OXB) in the PVT decreased exploration of the center area and the novel object indicating that the center area and the object had more aversive properties in orexin treated rats. Both OXA and OXB microinjections in the PVT increased the expression of freezing and grooming behaviors which are indicative of a negative emotional state. The results indicate that microinjections of orexins in the PVT made the test situation more aversive and produced avoidance behaviors. This suggests that orexins may act at the PVT to modulate behaviors associated with a negative emotional state. (C) 2010 Elsevier Inc. All rights reserved.
KeywordParaventricular nucleus of the thalamus Midline thalamus Orexin Hypocretin Thalamus Arousal Emotion Motivation
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
Funding Project一室隋南课题组
WOS IDWOS:000275617800017
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/7257
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorGilbert J. Kirouac
Affiliation1.Univ Manitoba, Dept Oral Biol, Fac Dent, Winnipeg, MB R3E 0W2, Canada
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Yonghui,Li, Sa,Wei, Chuguang,et al. Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2010,95(1):121-128.
APA Li, Yonghui.,Li, Sa.,Wei, Chuguang.,Wang, Huiying.,Sui, Nan.,...&Gilbert J. Kirouac.(2010).Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,95(1),121-128.
MLA Li, Yonghui,et al."Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 95.1(2010):121-128.
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