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Structural Modifications of the Brain in Acclimatization to High-Altitude
Zhang, Jiaxing1,2; Yan, Xiaodan3; Shi, Jinfu1; Gong, Qiyong4; Weng, Xuchu1; Liu, Yijun5,6; Zhang JX(张建新)
AbstractAdaptive changes in respiratory and cardiovascular responses at high altitude (HA) have been well clarified. However, the central mechanisms underlying HA acclimatization remain unclear. Using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) with fractional anisotropy (FA) calculation, we investigated 28 Han immigrant residents (17-22 yr) born and raised at HA of 2616-4200 m in Qinghai-Tibetan Plateau for at least 17 years and who currently attended college at sea-level (SL). Their family migrated from SL to HA 2-3 generations ago and has resided at HA ever since. Control subjects were matched SL residents. HA residents (vs. SL) showed decreased grey matter volume in the bilateral anterior insula, right anterior cingulate cortex, bilateral prefrontal cortex, left precentral cortex, and right lingual cortex. HA residents (vs. SL) had significantly higher FA mainly in the bilateral anterior limb of internal capsule, bilateral superior and inferior longitudinal fasciculus, corpus callosum, bilateral superior corona radiata, bilateral anterior external capsule, right posterior cingulum, and right corticospinal tract. Higher FA values in those regions were associated with decreased or unchanged radial diffusivity coinciding with no change of longitudinal diffusivity in HA vs. SL group. Conversely, HA residents had lower FA in the left optic radiation and left superior longitudinal fasciculus. Our data demonstrates that HA acclimatization is associated with brain structural modifications, including the loss of regional cortical grey matter accompanied by changes in the white matter, which may underlie the physiological adaptation of residents at HA.
Subject Area认知神经科学
Source PublicationPLOS ONE
Indexed BySCI
Funding Project二室翁旭初课题组
WOS IDWOS:000279522500016
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorZhang JX(张建新)
Affiliation1.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
2.Xiamen Univ, Coll Med, Dept Physiol & Neurobiol, Xiamen, Peoples R China
3.NYU, Langone Med Ctr, New York, NY USA
4.Sichuan Univ, W China Hosp, Huaxi Magnet Resonance Res Ctr, Chengdu 610064, Peoples R China
5.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32611 USA
6.Univ Florida, Dept Neurosci, McKnight Brain Inst, Gainesville, FL 32610 USA
Recommended Citation
GB/T 7714
Zhang, Jiaxing,Yan, Xiaodan,Shi, Jinfu,et al. Structural Modifications of the Brain in Acclimatization to High-Altitude[J]. PLOS ONE,2010,5(7).
APA Zhang, Jiaxing.,Yan, Xiaodan.,Shi, Jinfu.,Gong, Qiyong.,Weng, Xuchu.,...&张建新.(2010).Structural Modifications of the Brain in Acclimatization to High-Altitude.PLOS ONE,5(7).
MLA Zhang, Jiaxing,et al."Structural Modifications of the Brain in Acclimatization to High-Altitude".PLOS ONE 5.7(2010).
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