Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
| Toward discovery science of human brain function | |
Biswal, Bharat B.2; Mennes, Maarten1; Zuo, Xi-Nian1 ; Gohel, Suril2; Kelly, Clare1; Smith, Steve M.3; Beckmann, Christian F.3; Adelstein, Jonathan S.1; Buckner, Randy L.4; Colcombe, Stan5; Dogonowski, Anne-Marie6; Ernst, Monique7; Fair, Damien8; Hampson, Michelle9; Hoptman, Matthew J.10; Hyde, James S.11; Kiviniemi, Vesa J.12; Kotter, Rolf13; Li, Shi-Jiang11; Lin, Ching-Po; Lowe, Mark J.14; Mackay, Clare3; Madden, David J.15; Madsen, Kristoffer H.6; Margulies, Daniel S.16; Mayberg, Helen S.17,18; McMahon, Katie19; Monk, Christopher S.20; Mostofsky, Stewart H.21; Nagel, Bonnie J.22; Pekar, James J.23; Peltier, Scott J.24; Petersen, Steven E.25; Riedl, Valentin26,27; Rombouts, Serge A. R. B.28,29; Rypma, Bart30,31; Schlaggar, Bradley L.32; Schmidt, Sein33; Seidler, Rachael D.20,34; Siegle, Greg J.35; Sorg, Christian36; Teng, Gao-Jun37; Veijola, Juha38,39; Villringer, Arno33,40; Walter, Martin41; Wang, Lihong15; Weng, Xu-Chu42; Whitfield-Gabrieli, Susan43; Williamson, Peter44; Windischberger, Christian45; Zang, Yu-Feng46; Zhang, Hong-Ying37; Castellanos, F. Xavier1,10; Milham, Michael P.1; Michael P. Milhamb
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| 摘要 | Although it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the development of common paradigms for interrogating the myriad functional systems in the brain without the constraints of a priori hypotheses. Resting-state functional MRI (R-fMRI) constitutes a candidate approach capable of addressing this challenge. Imaging the brain during rest reveals large-amplitude spontaneous low-frequency (< 0.1 Hz)fluctuations in the fMRI signal that are temporally correlated across functionally related areas. Referred to as functional connectivity, these correlations yield detailed maps of complex neural systems, collectively constituting an individual's "functional connectome." Reproducibility across datasets and individuals suggests the functional connectome has a common architecture, yet each individual's functional connectome exhibits unique features, with stable, meaningful interindividual differences in connectivity patterns and strengths. Comprehensive mapping of the functional connectome, and its subsequent exploitation to discern genetic influences and brain-behavior relationships, will require multicenter collaborative datasets. Here we initiate this endeavor by gathering R-fMRI data from 1,414 volunteers collected independently at 35 international centers. We demonstrate a universal architecture of positive and negative functional connections, as well as consistent loci of inter-individual variability. Age and sex emerged as significant determinants. These results demonstrate that independent R-fMRI datasets can be aggregated and shared. High-throughput R-fMRI can provide quantitative phenotypes for molecular genetic studies and biomarkers of developmental and pathological processes in the brain. To initiate discovery science of brain function, the 1000 Functional Connectomes Project dataset is freely accessible at www.nitrc.org/projects/fcon_1000/. |
| 关键词 | database neuroimaging open access reproducibility resting state |
| 学科领域 | 认知神经科学 |
| 2010-03-09 | |
| 语种 | 英语 |
| 发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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| ISSN | 0027-8424 |
| 卷号 | 107期号:10页码:4734-4739 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| 资助项目 | 二室翁旭初课题组 |
| WOS记录号 | WOS:000275368400045 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/7271 |
| 专题 | 中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Michael P. Milhamb |
| 作者单位 | 1.NYU, Phyllis Green & Randolph Cowen Inst Pediat Neuros, Ctr Child Study, Langone Med Ctr, New York, NY 10016 USA 2.Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Radiol, Newark, NJ 07103 USA 3.Univ Oxford, FMRIB Ctr, Oxford OX3 9DU, England 4.Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA 5.Univ Wales, Sch Psychol, Bangor, Gwynedd, Wales 6.Univ Copenhagen, Hvidovre Hosp, Danish Res Ctr Magnet Resonance, DK-2650 Hvidovre, Denmark 7.NIMH, Mood & Anxiety Disorders Program, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA 8.Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA 9.Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06511 USA 10.Nathan S Kline Inst Psychiat Res, Div Clin Res, Orangeburg, NY 10962 USA 11.Med Coll Wisconsin, Biophys Res Inst, Milwaukee, WI 53226 USA 12.Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland 13.Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Ctr Neurosci, NL-6500 HB Nijmegen, Netherlands 14.Cleveland Clin, Imaging Inst, Cleveland, OH 44195 USA 15.Duke Univ, Med Ctr, Brain Imaging & Anal Ctr, Durham, NC 27710 USA 16.Max Planck Inst Human Cognit & Brain Sci, Dept Cognit Neurol, D-04103 Leipzig, Germany 17.Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30322 USA 18.Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA 19.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia 20.Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA 21.Kennedy Krieger Inst, Lab Neurocognit & Imaging Res, Baltimore, MD 21205 USA 22.Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97239 USA 23.Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD 21205 USA 24.Univ Michigan, Funct MRI Lab, Ann Arbor, MI 48109 USA 25.Washington Univ, Sch Med, McDonnell Ctr Higher Brain Funct, St Louis, MO 63110 USA 26.Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-81675 Munich, Germany 27.Tech Univ Munich, Klinikum Rechts Isar, Dept Neuroradiol, D-81675 Munich, Germany 28.Leiden Univ, Inst Psychol, Med Ctr, Leiden, Netherlands 29.Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands 30.Univ Texas Dallas, Ctr Brain Hlth, Richardson, TX 75080 USA 31.Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 75080 USA 32.Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA 33.Charite, Dept Neurol, D-10117 Berlin, Germany 34.Univ Michigan, Sch Kinesiol, Ann Arbor, MI 48109 USA 35.Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA 36.Tech Univ Munich, Klinikum Rechts Isar, Dept Psychiat, D-81675 Munich, Germany 37.Southeast Univ, Jiangsu Key Lab Mol & Funct Imaging, Dept Radiol, Zhong Da Hosp, Nanjing 210009, Peoples R China 38.Univ Oulu, Dept Psychiat, Inst Clin Med, Oulu 90014, Finland 39.Univ Oulu, Dept Publ Hlth Sci, Inst Hlth Sci, Oulu 90014, Finland 40.Berlin NeuroImaging Ctr, D-10099 Berlin, Germany 41.Otto VonGuericke Univ Magdegurg, Dept Psychiat, D-39106 Magdeburg, Germany 42.Chinese Acad Sci, Lab Higher Brain Funct, Inst Psychol, Beijing 100864, Peoples R China 43.MIT, Dept Brain & Cognit Sci, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA 44.Univ Western Ontario, Dept Psychiat, London, ON N6A 3H8, Canada 45.Med Univ Vienna, Ctr Med Phys & Biomed Engn, Vienna, Austria 46.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Biswal, Bharat B.,Mennes, Maarten,Zuo, Xi-Nian,et al. Toward discovery science of human brain function[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(10):4734-4739. |
| APA | Biswal, Bharat B..,Mennes, Maarten.,Zuo, Xi-Nian.,Gohel, Suril.,Kelly, Clare.,...&Michael P. Milhamb.(2010).Toward discovery science of human brain function.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(10),4734-4739. |
| MLA | Biswal, Bharat B.,et al."Toward discovery science of human brain function".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.10(2010):4734-4739. |
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