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Toward discovery science of human brain function
Biswal, Bharat B.2; Mennes, Maarten1; Zuo, Xi-Nian1; Gohel, Suril2; Kelly, Clare1; Smith, Steve M.3; Beckmann, Christian F.3; Adelstein, Jonathan S.1; Buckner, Randy L.4; Colcombe, Stan5; Dogonowski, Anne-Marie6; Ernst, Monique7; Fair, Damien8; Hampson, Michelle9; Hoptman, Matthew J.10; Hyde, James S.11; Kiviniemi, Vesa J.12; Kotter, Rolf13; Li, Shi-Jiang11; Lin, Ching-Po; Lowe, Mark J.14; Mackay, Clare3; Madden, David J.15; Madsen, Kristoffer H.6; Margulies, Daniel S.16; Mayberg, Helen S.17,18; McMahon, Katie19; Monk, Christopher S.20; Mostofsky, Stewart H.21; Nagel, Bonnie J.22; Pekar, James J.23; Peltier, Scott J.24; Petersen, Steven E.25; Riedl, Valentin26,27; Rombouts, Serge A. R. B.28,29; Rypma, Bart30,31; Schlaggar, Bradley L.32; Schmidt, Sein33; Seidler, Rachael D.20,34; Siegle, Greg J.35; Sorg, Christian36; Teng, Gao-Jun37; Veijola, Juha38,39; Villringer, Arno33,40; Walter, Martin41; Wang, Lihong15; Weng, Xu-Chu42; Whitfield-Gabrieli, Susan43; Williamson, Peter44; Windischberger, Christian45; Zang, Yu-Feng46; Zhang, Hong-Ying37; Castellanos, F. Xavier1,10; Milham, Michael P.1; Michael P. Milhamb
2010-03-09
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
SubtypeArticle
Volume107Issue:10Pages:4734-4739
AbstractAlthough it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the development of common paradigms for interrogating the myriad functional systems in the brain without the constraints of a priori hypotheses. Resting-state functional MRI (R-fMRI) constitutes a candidate approach capable of addressing this challenge. Imaging the brain during rest reveals large-amplitude spontaneous low-frequency (< 0.1 Hz)fluctuations in the fMRI signal that are temporally correlated across functionally related areas. Referred to as functional connectivity, these correlations yield detailed maps of complex neural systems, collectively constituting an individual's "functional connectome." Reproducibility across datasets and individuals suggests the functional connectome has a common architecture, yet each individual's functional connectome exhibits unique features, with stable, meaningful interindividual differences in connectivity patterns and strengths. Comprehensive mapping of the functional connectome, and its subsequent exploitation to discern genetic influences and brain-behavior relationships, will require multicenter collaborative datasets. Here we initiate this endeavor by gathering R-fMRI data from 1,414 volunteers collected independently at 35 international centers. We demonstrate a universal architecture of positive and negative functional connections, as well as consistent loci of inter-individual variability. Age and sex emerged as significant determinants. These results demonstrate that independent R-fMRI datasets can be aggregated and shared. High-throughput R-fMRI can provide quantitative phenotypes for molecular genetic studies and biomarkers of developmental and pathological processes in the brain. To initiate discovery science of brain function, the 1000 Functional Connectomes Project dataset is freely accessible at www.nitrc.org/projects/fcon_1000/.
Keyworddatabase neuroimaging open access reproducibility resting state
Subject Area认知神经科学
Indexed BySCI
Language英语
Funding Project二室翁旭初课题组
WOS IDWOS:000275368400045
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/7271
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorMichael P. Milhamb
Affiliation1.NYU, Phyllis Green & Randolph Cowen Inst Pediat Neuros, Ctr Child Study, Langone Med Ctr, New York, NY 10016 USA
2.Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Radiol, Newark, NJ 07103 USA
3.Univ Oxford, FMRIB Ctr, Oxford OX3 9DU, England
4.Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA
5.Univ Wales, Sch Psychol, Bangor, Gwynedd, Wales
6.Univ Copenhagen, Hvidovre Hosp, Danish Res Ctr Magnet Resonance, DK-2650 Hvidovre, Denmark
7.NIMH, Mood & Anxiety Disorders Program, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
8.Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA
9.Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06511 USA
10.Nathan S Kline Inst Psychiat Res, Div Clin Res, Orangeburg, NY 10962 USA
11.Med Coll Wisconsin, Biophys Res Inst, Milwaukee, WI 53226 USA
12.Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland
13.Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Ctr Neurosci, NL-6500 HB Nijmegen, Netherlands
14.Cleveland Clin, Imaging Inst, Cleveland, OH 44195 USA
15.Duke Univ, Med Ctr, Brain Imaging & Anal Ctr, Durham, NC 27710 USA
16.Max Planck Inst Human Cognit & Brain Sci, Dept Cognit Neurol, D-04103 Leipzig, Germany
17.Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30322 USA
18.Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
19.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia
20.Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA
21.Kennedy Krieger Inst, Lab Neurocognit & Imaging Res, Baltimore, MD 21205 USA
22.Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97239 USA
23.Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD 21205 USA
24.Univ Michigan, Funct MRI Lab, Ann Arbor, MI 48109 USA
25.Washington Univ, Sch Med, McDonnell Ctr Higher Brain Funct, St Louis, MO 63110 USA
26.Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-81675 Munich, Germany
27.Tech Univ Munich, Klinikum Rechts Isar, Dept Neuroradiol, D-81675 Munich, Germany
28.Leiden Univ, Inst Psychol, Med Ctr, Leiden, Netherlands
29.Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands
30.Univ Texas Dallas, Ctr Brain Hlth, Richardson, TX 75080 USA
31.Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 75080 USA
32.Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
33.Charite, Dept Neurol, D-10117 Berlin, Germany
34.Univ Michigan, Sch Kinesiol, Ann Arbor, MI 48109 USA
35.Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA
36.Tech Univ Munich, Klinikum Rechts Isar, Dept Psychiat, D-81675 Munich, Germany
37.Southeast Univ, Jiangsu Key Lab Mol & Funct Imaging, Dept Radiol, Zhong Da Hosp, Nanjing 210009, Peoples R China
38.Univ Oulu, Dept Psychiat, Inst Clin Med, Oulu 90014, Finland
39.Univ Oulu, Dept Publ Hlth Sci, Inst Hlth Sci, Oulu 90014, Finland
40.Berlin NeuroImaging Ctr, D-10099 Berlin, Germany
41.Otto VonGuericke Univ Magdegurg, Dept Psychiat, D-39106 Magdeburg, Germany
42.Chinese Acad Sci, Lab Higher Brain Funct, Inst Psychol, Beijing 100864, Peoples R China
43.MIT, Dept Brain & Cognit Sci, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
44.Univ Western Ontario, Dept Psychiat, London, ON N6A 3H8, Canada
45.Med Univ Vienna, Ctr Med Phys & Biomed Engn, Vienna, Austria
46.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Recommended Citation
GB/T 7714
Biswal, Bharat B.,Mennes, Maarten,Zuo, Xi-Nian,et al. Toward discovery science of human brain function[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(10):4734-4739.
APA Biswal, Bharat B..,Mennes, Maarten.,Zuo, Xi-Nian.,Gohel, Suril.,Kelly, Clare.,...&Michael P. Milhamb.(2010).Toward discovery science of human brain function.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(10),4734-4739.
MLA Biswal, Bharat B.,et al."Toward discovery science of human brain function".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.10(2010):4734-4739.
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