Schizophrenia patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-posiitve network
Haihong Liu; Yoshio Kaneko; Xuan Ouyang; Li Li; Yihui Hao; Eric YH Chen; Tianzi Jiang; Yuan Zhou; Zhening Liu
2010
发表期刊Schizophrenia Bulletin
摘要Background: Abnormal connectivity of the anticorrelated intrinsic networks, the task-negative network (TNN), and the task-positive network (TPN) is implicated in schizophrenia. Comparisons between schizophrenic patients and their unaffected siblings enable further understanding of illness susceptibility and pathophysiology. We examined the resting-state connectivity differences in the intrinsic networks between schizophrenic patients, their unaffected siblings, and healthy controls. Methods: Resting-state functional magnetic resonance images were obtained from 25 individuals in each subject group. The posterior cingulate cortex/precuneus and right dorsolateral prefrontal cortex were used as seed regions to identify the TNN and TPN through functional connectivity analysis. Interregional connectivity strengths were analyzed using overlapped intrinsic networks composed of regions common to all subject groups. Results: Schizophrenic patients and their unaffected siblings showed increased connectivity in the TNN between the bilateral inferior temporal gyri. By contrast, schizophrenic patients alone demonstrated increased connectivity between the posterior cingulate cortex/precuneus and left inferior temporal gyrus and between the ventral medial prefrontal cortex and right lateral parietal cortex in the TNN. Schizophrenic patients exhibited increased connectivity between the left dorsolateral prefrontal cortex and right inferior frontal gyrus in the TPN relative to their unaffected siblings, though this trend only approached statistical significance in comparison to healthy controls. Conclusion: Resting-state hyperconnectivity of the intrinsic networks may disrupt network coordination and thereby contribute to the pathophysiology of schizophrenia. Similar, though milder, hyperconnectivity of the TNN in unaffected siblings of schizophrenic patients may contribute to the identification of schizophrenia endophenotypes and ultimately to the determination of schizophrenia risk genes.
关键词schizophrenia unaffected sibling defaultmode network functional connectivity resting-state
学科领域医学心理学
收录类别SCI
语种英语
资助项目三室李纾课题组
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/7305
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Zhening Liu
推荐引用方式
GB/T 7714
Haihong Liu,Yoshio Kaneko,Xuan Ouyang,et al. Schizophrenia patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-posiitve network[J]. Schizophrenia Bulletin,2010.
APA Haihong Liu.,Yoshio Kaneko.,Xuan Ouyang.,Li Li.,Yihui Hao.,...&Zhening Liu.(2010).Schizophrenia patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-posiitve network.Schizophrenia Bulletin.
MLA Haihong Liu,et al."Schizophrenia patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-posiitve network".Schizophrenia Bulletin (2010).
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