Association between intelligence and COMT genotypes in Chinese healthy children

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Association between intelligence and COMT genotypes in Chinese healthy children
	Lu LP; Shi JN(施建农)
	2010
会议名称	4th International Conference on Bioinformatics and Biomedical Engineering
会议日期	2010
会议地点	Chengdu, China
摘要	Catechol-O-methyl transferase (COMT) influences dopamine concentration in the pre-frontal cortex (PFC). The G/A transition in the exon 4 of the COMT gene, which results in a valine (Val) to methionine (Met) amino acid substitution (Val158Met), can bring on different enzymatic activities. Much research has found that the Met/Met genotype associated with low enzymatic activity and may enhance cognitive function. We applied one-way ANOVA to detect the effect of the COMT genotypes to intelligence in 108 Chinese children with polymerase chain reaction (PCR) methods. We found COMT Val158Met polymorphism had a significant main effect on intelligence (F (2, 102) = 3.47, p=0.035) and it could predict 4.7% of intelligence. Our results also suggest that Met/Met genotype has a positive effect on intelligence. However, we found no significant interaction between gender and COMT genotype to intelligence.
关键词	Intelligence Catechol-O-methyl transferase (COMT) functional polymorphism
语种	英语
文献类型	会议论文
条目标识符	http://ir.psych.ac.cn/handle/311026/8827
专题	中国科学院心理研究所回溯数据库(1956-2010)
推荐引用方式 GB/T 7714	Lu LP,Shi JN. Association between intelligence and COMT genotypes in Chinese healthy children[C],2010.

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