PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
Association between creativity and COMT genotype
Lu LP; Shi JN(施建农)
Conference Name2010 4th International Conference on Bioinformatics and Biomedical Engineering
Conference Date2010
Conference PlaceChengdu, China
AbstractCatechol-O-methyl transferase (COMT) influences dopamine concentration in the pre-frontal cortex (PFC). The G/A transition in the exon 4 of the COMT gene, which results in a valine (Val) to methionine (Met) amino acid substitution (Val158Met), can bring on different enzymatic activities. Much research has found that the Met/Met genotype associated with low enzymatic activity and may enhance cognitive function. Our research aimed to test the association between COMT genotype and creativity. We applied one-way ANOVA to detect the effect of the COMT genotypes to creative ability and creative potentials in 108 Chinese children with polymerase chain reaction (PCR) methods. COMT genotypes were not related to creative ability and creative potential except imagination. Val/Val carriers are more likely to imagine than Met/Met carriers (F (2, 105) =4.082, p=.02). We also found that COMT Val158Met polymorphism had a significant main effect on intelligence (F (2, 102) = 3.47, p=0.035) and it could predict 4.7% of intelligence. Our results suggest that Met/Met genotype has a positive effect on intelligence but not on creative ability. However, we found no significant interaction between gender and COMT genotype to intelligence.
Keywordcreative ability creative potential Catechol-O-methyl transferase (COMT) functional polymorphism
Subject Area发展心理学
Indexed ByEI
Document Type会议论文
Recommended Citation
GB/T 7714
Lu LP,Shi JN. Association between creativity and COMT genotype[C],2010.
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