Association between creativity and COMT genotype

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	Association between creativity and COMT genotype
	Lu LP; Shi JN(施建农)
	2010
会议名称	2010 4th International Conference on Bioinformatics and Biomedical Engineering
会议日期	2010
会议地点	Chengdu, China
摘要	Catechol-O-methyl transferase (COMT) influences dopamine concentration in the pre-frontal cortex (PFC). The G/A transition in the exon 4 of the COMT gene, which results in a valine (Val) to methionine (Met) amino acid substitution (Val158Met), can bring on different enzymatic activities. Much research has found that the Met/Met genotype associated with low enzymatic activity and may enhance cognitive function. Our research aimed to test the association between COMT genotype and creativity. We applied one-way ANOVA to detect the effect of the COMT genotypes to creative ability and creative potentials in 108 Chinese children with polymerase chain reaction (PCR) methods. COMT genotypes were not related to creative ability and creative potential except imagination. Val/Val carriers are more likely to imagine than Met/Met carriers (F (2, 105) =4.082, p=.02). We also found that COMT Val158Met polymorphism had a significant main effect on intelligence (F (2, 102) = 3.47, p=0.035) and it could predict 4.7% of intelligence. Our results suggest that Met/Met genotype has a positive effect on intelligence but not on creative ability. However, we found no significant interaction between gender and COMT genotype to intelligence.
关键词	creative ability creative potential Catechol-O-methyl transferase (COMT) functional polymorphism
学科领域	发展心理学
收录类别	EI
文献类型	会议论文
条目标识符	http://ir.psych.ac.cn/handle/311026/8828
专题	中国科学院心理研究所回溯数据库(1956-2010)
推荐引用方式 GB/T 7714	Lu LP,Shi JN. Association between creativity and COMT genotype[C],2010.

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