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Kuang PG(匡培根); Dai FL(戴富林); Zhang FY(张凤英); Kuang PZ(匡培梓); Chen SS(陈双双)
Source PublicationJournal of Traditional Chinese Medicine
Other Abstract<正> Anisodine(AT_3)is a new alkaloid isolatedfrom Scopolia tangutica,Anisodus tanguticus,a plant of Solauaeeae family,collected fromMt.Tanggute.AT_3 has anticholinergic property.The influences of AT_3 on memory behavior,hip-pocampal electrical activity and acetylcholinecontent in animals were studied.The evalua-tion of memory deficits was based on the fol-lowing:(1)percentage of conditioned passiveavoidance reaction(CAR),(2)mean responsetime,(3)mean ability to perform correctly 5successive times in 10 trials,(4)mean numberof trials to correctly perform 9 out of 10 trials.It was found that AT_3 influences unconsolidatedmemory(three day training period)more thanconsolided memory(six day training period).It was also observed that the nmemonia effectsof AT_3 was associated with ECoG changes andcholinergic reduction in hippocampus.The majorfindings arising from studies of hippocampalelectrical activity in orienting experiments isthat hippocampal electrical response decreasedafter AT_3 injection.These findings suggestedthat the chronic administration of AT_3 raises thepossibility of impairing the ability of patients,particularly elderly ones,to learn new materialand to store,or acquire new information intolong-term memory.
Keyword樟柳碱 东莨菪碱 乙酰胆碱 短时记忆 神经系统疾病 记忆障碍 帕金森氏病 海马
Subject Area生理心理学/生物心理学
Document Type期刊论文
Recommended Citation
GB/T 7714
Kuang PG,Dai FL,Zhang FY,et al. EFFECTS OF ANISODINE ON MEMORY[J]. Journal of Traditional Chinese Medicine,1982,2(04):277-284.
APA Kuang PG,Dai FL,Zhang FY,Kuang PZ,&Chen SS.(1982).EFFECTS OF ANISODINE ON MEMORY.Journal of Traditional Chinese Medicine,2(04),277-284.
MLA Kuang PG,et al."EFFECTS OF ANISODINE ON MEMORY".Journal of Traditional Chinese Medicine 2.04(1982):277-284.
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