Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70
	Wu WP(吴卫平); Kuang PG(匡培根); Jiang SJ(姜树军); Zhang XS(张小澍); Yang JJ(杨炯炯); Sui N(隋南); Albert Chen; Kuang PZ(匡培梓)
摘要	The effect of Batroxobin on spatial memory disorder of left temporal ischemic rats and the expression of HSP32 and HSP70 were investigated with Morri`s water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats in searching a goal were significantly longer than those of the sham-operated rats and at the same time HSP32 and HSP70 expression of left temporal ischemic region in rats was significantly increased as compared with the sham-operated rats. However, the mean reaction time and distance of the Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of HSP32 and HSP70 immune reactive cells of Batroxobin-treated rats was also less than that of the ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats; and the down-regulation of the expression of HSP32 and HSP70 is probably related to the attenuation of ischemic injury.
学科领域	生理心理学/生物心理学
	2000
语种	英语
发表期刊	Journal of Traditional Chinese Medicine
卷号	20 期号:4 页码:297-301
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/9823
专题	中国科学院心理研究所回溯数据库(1956-2010)
推荐引用方式 GB/T 7714	Wu WP,Kuang PG,Jiang SJ,et al. Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70[J]. Journal of Traditional Chinese Medicine,2000,20(4):297-301.
APA	Wu WP.,Kuang PG.,Jiang SJ.,Zhang XS.,Yang JJ.,...&Kuang PZ.(2000).Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70.Journal of Traditional Chinese Medicine,20(4),297-301.
MLA	Wu WP,et al."Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70".Journal of Traditional Chinese Medicine 20.4(2000):297-301.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Effects of Batroxobi（321KB）			开放获取	CC BY-NC-SA	浏览下载