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Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70
Wu WP(吴卫平); Kuang PG(匡培根); Jiang SJ(姜树军); Zhang XS(张小澍); Yang JJ(杨炯炯); Sui N(隋南); Albert Chen; Kuang PZ(匡培梓)
2000
Source PublicationJournal of Traditional Chinese Medicine
Volume20Issue:4Pages:297-301
AbstractThe effect of  Batroxobin on spatial memory disorder of left temporal ischemic rats and the expression of HSP32 and  HSP70 were investigated with Morri`s water maze and  immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats in searching a goal were significantly longer than those of the sham-operated rats and at the same time  HSP32 and HSP70 expression of left temporal ischemic region in rats was significantly increased as compared with the sham-operated rats. However, the mean reaction time and distance of the  Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic  rats. The number of  HSP32 and  HSP70 immune reactive cells of  Batroxobin-treated rats was also less than that of the ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats; and the down-regulation of the expression of  HSP32 and  HSP70 is probably related to the attenuation of ischemic injury.
Subject Area生理心理学/生物心理学
Language英语
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/9823
Collection中国科学院心理研究所回溯数据库(1956-2010)
Recommended Citation
GB/T 7714
Wu WP,Kuang PG,Jiang SJ,et al. Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70[J]. Journal of Traditional Chinese Medicine,2000,20(4):297-301.
APA Wu WP.,Kuang PG.,Jiang SJ.,Zhang XS.,Yang JJ.,...&Kuang PZ.(2000).Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70.Journal of Traditional Chinese Medicine,20(4),297-301.
MLA Wu WP,et al."Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70".Journal of Traditional Chinese Medicine 20.4(2000):297-301.
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