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Alternative TitleVisuospatial dysfunction in mild cognitive impairment: a functional magnetic resonance imaging study
白静; 王荫华; 翁旭初; 谢晟; 黄一宁
Correspondent Emailbaijingnv@ sina. com
Other AbstractObjective:To contribute to the early diagnosis of Alzheimer disease (AD). Methods: we detected the visuospatial function in the patients with mild cognitive impairment (MCI) using the functional magnetic resonance imaging (fMRI). Nine patients with MCI and nine controls matching in age, gender, level of education and handedness distinguished the analogue clocks with the same location of the hands presented visually while the MR machine was scanning. The raw data of the fMRI were processed with the software AFNI. The reaction time and correct ratio were analyzed by means of independent-samples T test or paired-samples T test with the software Excel. Results:The patients manifested longer reaction time and lower correct ratio than the controls, the brain activation showed less intensity and extension in the patients bilateral parietal lobes,temporal neocortex adjacent to the occipital lobes and the extrastriatal visual cortex except for the right dorsal lateral prefrontal lobe. The activation was prominently in the right hemisphere. Conclusion: The patients with MCI have the deficit in visuospatial function, which can be tested by fMRI.
KeywordAlzheimer病 轻度认知障碍 视空间 功能磁共振成像
Subject Area医学心理学
Source Publication中国神经科学杂志
Indexed ByCSCD
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Document Type期刊论文
Corresponding Author王荫华
Recommended Citation
GB/T 7714
白静,王荫华,翁旭初,等. 轻度认知障碍患者视空间功能的fMRI研究[J]. 中国神经科学杂志,2003,19(5):277-281.
APA 白静,王荫华,翁旭初,谢晟,&黄一宁.(2003).轻度认知障碍患者视空间功能的fMRI研究.中国神经科学杂志,19(5),277-281.
MLA 白静,et al."轻度认知障碍患者视空间功能的fMRI研究".中国神经科学杂志 19.5(2003):277-281.
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