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A machine learning-driven study indicates emodin improves cardiac hypertrophy by modulation of mitochondrial SIRT3 signaling 期刊论文
PHARMACOLOGICAL RESEARCH, 2020, 卷号: 155, 页码: 13
Authors:  Gao, Jian;  Zhang, Kunlin;  Wang, Yi;  Guo, Rui;  Liu, Hao;  Jia, Caixia;  Sun, Xiaoli;  Wu, Chaoyong;  Wang, Wei;  Du, Jie;  Chen, Jianxin
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Rheum palmatum L.  Emodin  Cardiac hypertrophy  SIRT3  Mitochondrial dysfunction  
中药治疗创伤后应激障碍的研究进展 期刊论文
中国实验方剂学杂志, 2020, 卷号: 26, 期号: 7, 页码: 211-217
Authors:  李秋雨;  郭建友;  姚子蔚;  王晓玫;  石晋丽
Adobe PDF(290Kb)  |  Favorite  |  View/Download:22/0  |  Submit date:2020/07/27
创伤后应激障碍  中药单体  单味中药提取物  中药复方  
应激激活蛋白激酶JNK 在中枢炎性免疫诱导的 抑郁样行为中的作用 学位论文
理学博士, 中国科学院心理研究所: 中国科学院心理研究所, 2019
Authors:  张军涛
Adobe PDF(2534Kb)  |  Favorite  |  View/Download:141/1  |  Submit date:2019/12/23
抑郁样行为  JNK 激酶  炎性细胞因子  糖皮质激素受体  缰核  杏仁 核  杏仁 核  内侧前额叶  海马  伏隔核  
N-3系多不饱和脂肪酸对中枢炎症诱发的抑郁样行为的改善作用及其调控机制 学位论文
理学博士, 中国科学院心理研究所: 中国科学院心理研究所, 2019
Authors:  赵亚伟
Adobe PDF(3738Kb)  |  Favorite  |  View/Download:153/1  |  Submit date:2020/01/19
LPS  N-3 PUFAs  中枢神经系统炎症  抑郁样行为  MAPK信号通路  TNF-α  小胶质细胞  
Alantolactone exhibits selective antitumor effects in HELA human cervical cancer cells by inhibiting cell migration and invasion, G2/M cell cycle arrest, mitochondrial mediated apoptosis and targeting Nf-kB signalling pathway 期刊论文
JOURNAL OF BUON, 2019, 卷号: 24, 期号: 6, 页码: 2310-2315
Authors:  Yibing Zhang;  Zhao, Yong;  Ran, Yongwang;  Guo, Jianyou;  Cui, Haifeng;  Liu, Sha
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alantolactone  apoptosis  cervical cancer  cytometry  cell cycle  
TLR4在社会挫败应激致抑郁样行为中的作用 学位论文
理学博士, 中国科学院心理研究所: 中国科学院大学, 2019
Authors:  张克
Adobe PDF(2211Kb)  |  Favorite  |  View/Download:118/2  |  Submit date:2019/07/09
社会挫败应激  TLR4  抑郁样行为  绝望行为  DNA甲基化  
Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression 期刊论文
PSYCHIATRY RESEARCH, 2019, 卷号: 276, 页码: 79-86
Authors:  Li, Mingzhen;  Teng, Huajing;  Sun, Guangqiang;  Zhao, Jingjie;  Fan, Min;  Zhao, Zhenlin;  Zhou, JianJun;  Zhao, Mei
Adobe PDF(803Kb)  |  Favorite  |  View/Download:43/1  |  Submit date:2019/06/12
Calpain 2 (Capn2)  Vesicle-associated membrane protein 7 (Vamp7)  C-type natriuretic peptide (Cnp)  PC12 cells  Animal model of depression  
From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: Detecting the critical transition from health to major depression 期刊论文
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2018, 卷号: 90, 页码: 1-15
Authors:  Stapelberg, N. J. C.;  Pratt, R.;  Neumann, D. L.;  Shum, D. H. K.;  Brandis, S.;  Muthukkumarasamy, V.;  Stantic, B.;  Blumenstein, M.;  Headrick, J. P.
Adobe PDF(1975Kb)  |  Favorite  |  View/Download:50/0  |  Submit date:2018/08/14
Major Depressive Disorder  Critical Transition  Feedback Loop Transition Biomarker  Psycho-immune-neuroendocrine Network  Feedback Loop  Network Motif  
Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation 期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9, 页码: 1-14
Authors:  Zhao, Ya-wei;  Pan, Yu-qin;  Tang, Ming-ming;  Lin, Wen-juan
Adobe PDF(3912Kb)  |  Favorite  |  View/Download:53/1  |  Submit date:2018/07/02
depression  p38  neuroinflammation  habenula  fluoxetine  SB203580  
抑郁症研究和治疗的新靶标:JNK信号通路的作用 期刊论文
科学通报, 2018, 卷号: 63, 期号: 20, 页码: 1998 ~ 2009
Authors:  张军涛;  林文娟
Adobe PDF(2945Kb)  |  Favorite  |  View/Download:86/1  |  Submit date:2018/10/26
抑郁症  C-jun氨基端激酶  神经萎缩  神经发生  突触可塑性  神经炎症  兴奋性毒性  糖皮质激素抵抗