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Transient upregulation of immune activity induced by adolescent social stress is involved in cognitive deficit in adult male mice and early intervention with minocycline 期刊论文
BEHAVIOURAL BRAIN RESEARCH, 2019, 卷号: 374, 页码: 7
Authors:  Zhang, Yu;  Xu, Hang;  Wang, Jiesi;  Ren, Fengyan;  Shao, Feng;  Ellenbroek, Bart;  Lin, Wenjuan;  Wang, Weiwen
Favorite  |  View/Download:22/0  |  Submit date:2020/05/18
Adolescent social stress  Medial prefrontal cortex (mPFC)  Microglia  Tumor necrosis factor alpha (TNF alpha)  Cognitive flexibility  
Deficiencies of microglia and TNF alpha in the mPFC-mediated cognitive inflexibility induced by social stress during adolescence 期刊论文
BRAIN BEHAVIOR AND IMMUNITY, 2019, 卷号: 79, 页码: 256-266
Authors:  Zhang, Yu;  Xu, Hang;  Zhang, Fan;  Shao, Feng;  Ellenbroek, Bart;  Wang, Jiesi;  Wang, Weiwen
Adobe PDF(2176Kb)  |  Favorite  |  View/Download:110/1  |  Submit date:2019/08/19
Adolescent social stress  Medial prefrontal cortex (mPFC)  Microglia  Tumor necrosis factor alpha (TNF alpha)  Set-shifting  
Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake 期刊论文
JOURNAL OF AFFECTIVE DISORDERS, 2019, 卷号: 248, 页码: 52-58
Authors:  Wang, Weiwen;  Wang, Li;  Xu, Hang;  Cao, Chengqi;  Liu, Ping;  Luo, Shu;  Duan, Qing;  Ellenbroek, Bart;  Zhang, Xiangyang
Adobe PDF(281Kb)  |  Favorite  |  View/Download:146/1  |  Submit date:2019/03/25
Earthquake  Posttraumatic Stress Disorder  Cytokines, Interleukin 1 Beta (Il-1 Beta)  
An Improved Model of Physical and Emotional Social Defeat: Different Effects on Social Behavior and Body Weight of Adolescent Mice by Interaction With Social Support 期刊论文
FRONTIERS IN PSYCHIATRY, 2018, 卷号: 9, 页码: 8
Authors:  Li, Man;  Xu, Hang;  Wang, Weiwen
Adobe PDF(938Kb)  |  Favorite  |  View/Download:103/0  |  Submit date:2019/01/22
Adolescent  Physical Stress  Emotional Stress  Social Behavior  Social Support  
Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice 期刊论文
PSYCHONEUROENDOCRINOLOGY, 2018, 卷号: 88, 页码: 92-101
Authors:  Xu, Hang;  Wang, Jiesi;  Zhang, Ke;  Zhao, Mei;  Ellenbroek, Bart;  Shao, Feng;  Wang, Weiwen;  F. Shao;  W. Wang
Adobe PDF(968Kb)  |  Favorite  |  View/Download:69/1  |  Submit date:2018/05/28
Adolescent  Social stress  Cognitive inflexibility  Brain-derived neurotrophic factor (BDNF)  Epigenetic mechanism  
青少期应激诱发抑郁症认知功能障碍的中枢免疫机制及干预新策略 项目
项目类型: 面上项目, 项目编号: 31771217, 2018-2021
Leaders:  王玮文
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GABA能系统在应激诱发的抑郁症中的作用 期刊论文
心理科学进展, 2017, 卷号: 25, 期号: 12, 页码: 2075–2081
Authors:  徐航 陈焕新 3 王玮文 1,2;  陈焕新;  王玮文
Adobe PDF(540Kb)  |  Favorite  |  View/Download:121/2  |  Submit date:2018/01/05
应激  GABA 能系统  抑郁症  
中枢免疫失衡与认知功能障碍:聚焦TNFα的作用 期刊论文
心理科学进展, 2017, 卷号: 25, 期号: 12, 页码: 2036–2042
Authors:  张瑜;  林文娟;  王玮文
Adobe PDF(445Kb)  |  Favorite  |  View/Download:104/1  |  Submit date:2017/11/30
内稳态  TNFα  应激  突触可塑性  认知功能  
Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence 期刊论文
NEURAL PLASTICITY, 2017, 期号: 0, 页码: 1-11
Authors:  Zhang, Yu;  Shao, Feng;  Wang, Qiong;  Xie, Xi;  Wang, Weiwen
Adobe PDF(1833Kb)  |  Favorite  |  View/Download:82/0  |  Submit date:2017/03/28
Effects of Duloxetine Treatment on Cognitive Flexibility and BDNF Expression in the mPFC of Adult Male Mice Exposed to Social Stress during Adolescence 期刊论文
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2016, 卷号: 9
Authors:  Xu, Hang;  Zhang, Yu;  Zhang, Fan;  Yuan, San-na;  Shao, Feng;  Wang, Weiwen
Adobe PDF(1665Kb)  |  Favorite  |  View/Download:69/0  |  Submit date:2016/11/14
social stress  adolescent  cognitive flexibility  medial prefrontal cortex (mPFC)  brain-derived neurotrophic factor (BDNF)