FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors

doi:10.1177/0706743719870505

PSYCH OpenIR

	FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors
	Li, Gen 1,2; Wang, Li 1,2; Zhang, Kunlin 1,2; Cao, Chengqi 2,3; Cao, Xing 1,2; Fang, Ruojiao 1,2; Liu, Ping 4; Luo, Shu 4; Zhang, Xiangyang 1,2
通讯作者	Wang, Li(wangli1@psych.ac.cn)
摘要	Background: Post-traumatic stress disorder (PTSD) and depression are common mental disorders in individuals experiencing traumatic events. To date, few studies have studied the relationship between genetic basis and phenotypic heterogeneity of traumatized individuals. The present study examined the effects of four FKBP5 SNPs (rs1360780, rs3800373, rs9296158, and rs9470080) in four postdisaster groups (low symptom, predominantly depressive, predominantly PTSD, and combined PTSD-depression symptom groups) as identified by latent profile analysis. Methods: A total of 1,140 adults who experienced the 2008 Wenchuan earthquake participated in our study. Earthquake-related trauma, PTSD, and depressive symptoms were measured using standard psychometric instruments. The four FKBP5 SNPs were genotyped using a custom-by-design 2 x 48-Plex SNP scan (TM) Kit. Results: After adjusting for covariates, the main and gene-environment interaction effects of rs9470080 were all significant when the combined PTSD-depression group was compared with the low symptoms, predominantly depression and predominantly PTSD groups. rs9470080 TT genotype carriers had a higher risk of developing high co-occurring PTSD and depression symptoms than the C allele carriers. However, when trauma exposure was severe, the TT genotype carriers and C allele carriers did not differ in the risk of developing high co-occurring PTSD and depressive symptoms. The other three SNPs demonstrated no significant effects. Moreover, the rs3800373-rs9296158-rs1360780-rs9470080 haplotype A-G-C-T was found significantly associated with combined PTSD-depression symptoms. Conclusion: Our findings support the genetic basis of phenotypic heterogeneity in people exposed to trauma. Furthermore, the results reveal the possibility that the variants of FKBP5 gene may be associated with depression-PTSD comorbidity.
关键词	PTSD depression phenotypic heterogeneity FKBP5 G x E study
	2019-09-11
语种	英语
DOI	10.1177/0706743719870505
发表期刊	CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
ISSN	0706-7437
页码	9
收录类别	SCI ; SCI
资助项目	External Cooperation Program of Chinese Academy of Sciences[153111KYSB20160036] ; National Natural Science Foundation of China[31271099] ; National Natural Science Foundation of China[31471004] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; Beijing Municipal Science and Technology Commission[Z171100000117014]
出版者	SAGE PUBLICATIONS INC
WOS关键词	POSTTRAUMATIC-STRESS-DISORDER ; MAJOR DEPRESSION ; CHILDHOOD ABUSE ; MENTAL-HEALTH ; GENE ; RISK ; ASSOCIATION ; RESILIENCE ; TRAUMA ; POLYMORPHISMS
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000488358200001
资助机构	External Cooperation Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education ; Beijing Municipal Science and Technology Commission
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/30188
通讯作者	Wang, Li
作者单位	1.Chinese Acad Sci, Inst Psychol, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen, Peoples R China 4.Peoples Hosp Deyang City, Deyang, Sichuan, Peoples R China
推荐引用方式 GB/T 7714	Li, Gen,Wang, Li,Zhang, Kunlin,et al. FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors[J]. CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE,2019:9.
APA	Li, Gen.,Wang, Li.,Zhang, Kunlin.,Cao, Chengqi.,Cao, Xing.,...&Zhang, Xiangyang.(2019).FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors.CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE,9.
MLA	Li, Gen,et al."FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors".CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE (2019):9.